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FORMULASI SEDIAAN SABUN CAIR EKSTRAK DAUN SIRIH HIJAU (Piper battle folium L.) DAN EKSTRAK BAWANG PUTIH (Allium sativum L.) SEBAGAI ANTIJAMUR Candida albicans Nurul Marfuah, Rohmah Madya Ayu Fitriana, Solikah Ana Estikomah,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v2i2.2632

Abstract

Islam is a religion that likes cleanliness, in case of body hygiene, clothing, and environment. One of the diseases that arise because it does not keep the body clean is white discharge. Piper bettle folium and Alium sativum are some of the natural ingredients that has the potential as an antifungal. This research aims to see the effect of antifungal Candida albicans extract of Piper bettle folium and Alium sativum after formulated as a liquid soap preparation. Liquid soaps are made by hot process methods with 3 formulations of combination of Piper bettle folium and Alium sativum extract with a ratio of 1) 25%: 75% 2) 50%: 50% 3) 75%: 25%. The evaluation of liquid soap include organoleptic examination, pH, high foam, moisture content, homogeneity, and antifungal power test against Candida albicans fungus. The results of the testing of liquid soap quality of green betel leaf extract and garlic have met the standards SNI (Indonesia’s National Standards) set for the manufacture of liquid soap.The results showed that liquid soap extract of green betel leaf and garlic have antifungal activity against Candida albicans. The result of formulation with the highest inhibition zone is formulation 3 and formulation with the lowest inhibition zone is the formulation 1. The test of this liquid soap activity is higher than fluconazole as the positive control and liquid soap of female area spread in the market.
PENGARUH PUASA TERHADAP JUMLAH DAN MORFOLOGI SPERMATOZOA MENCIT (Mus musculus) Surya Amal, Nurul Marfuah,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v2i2.2630

Abstract

One of the benefits of fasting is being able to control testosterone levels in the blood so as not to exceed normal. Normal testosterone levels will produce good quality (morphology, viability, motility) and good quantity (number) of spermatozoa. Therefore, this  study was conducted to understand the effect of fasting on the number and morphology of spermatozoa in mice. This study is an experimental study with a completely randomized design trial (CRD) using5 treatments and 3 replications. The type of treatment given is not fasting (control); middle fasting month of Hijriah for 3 days (13th, 14th and 15th); Monday and Thursday fasting; fasting Daud (a day of fasting a day is not); and fasting every day for 36 days. Male mice used in this study were Balb C strains with an initial weight of 23-26 grams and in the age range of 8-10 weeks. Calculation of the number of epididymal spermatozoa carried out according to WHO procedures in Syamrizal (1995) and morphological observations of spermatozoa carried out included normal and abnormal. Data analysis used is one-way ANOVA with a significance level of 5%. The statistical program used for the analysis was the SPSS 20 program. The results showed that fasting could increase the number and percentage of normal spermatozoa in Balb C strain mice eventhough statistically the increase was not significantly different (sig.> 0.05). Based on the type of fasting that was done, fasting on Thursday Thursday had the highest effect on the increase in the number and percentage of normal spermatozoa. Then followed by fasting every day and fasting of Daud. While the mid-fasting month of Hijriah actually decreases the number and percentage of normal spermatozoa compared to controls.
PENGARUH PUASA TERHADAP JUMLAH DAN MORFOLOGI SPERMATOZOA MENCIT (Mus musculus) Surya Amal, Nurul Marfu'ah,
Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018)
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (20.332 KB) | DOI: 10.21111/pharmasipha.v2i2.2770

Abstract

One of the benefits of fasting is being able to control testosterone levels in the blood so as not to exceed normal. Normal testosterone levels will produce good quality (morphology, viability, motility) and good quantity (number) of spermatozoa. Therefore, this  study was conducted to understand the effect of fasting on the number and morphology of spermatozoa in mice. This study is an experimental study with a completely randomized design trial (CRD) using5 treatments and 3 replications. The type of treatment given is not fasting (control); middle fasting month of Hijriah for 3 days (13th, 14th and 15th); Monday and Thursday fasting; fasting Daud (a day of fasting a day is not); and fasting every day for 36 days. Male mice used in this study were Balb C strains with an initial weight of 23-26 grams and in the age range of 8-10 weeks. Calculation of the number of epididymal spermatozoa carried out according to WHO procedures in Syamrizal (1995) and morphological observations of spermatozoa carried out included normal and abnormal. Data analysis used is one-way ANOVA with a significance level of 5%. The statistical program used for the analysis was the SPSS 20 program. The results showed that fasting could increase the number and percentage of normal spermatozoa in Balb C strain mice eventhough statistically the increase was not significantly different (sig.> 0.05). Based on the type of fasting that was done, fasting on Thursday Thursday had the highest effect on the increase in the number and percentage of normal spermatozoa. Then followed by fasting every day and fasting of Daud. While the mid-fasting month of Hijriah actually decreases the number and percentage of normal spermatozoa compared to controls.
Rasio Lingkar Pinggang-Pinggul dan Kaitannya dengan Kadar Kolesterol Total pada Wanita Dewasa Nurohmi, Susi; Marfu'ah, Nurul; Naufalina, Mira Dian; Farhana, Siti Awalisanah Hani; Riza, Muhammad El
Nutri-Sains: Jurnal Gizi, Pangan dan Aplikasinya Vol 4, No 1 (2020)
Publisher : Universitas Islam Negeri Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/ns.2020.4.1.4706

Abstract

This study aimed to analyze the association between anthropometric assessments and total cholesterol levels among adult women. The research design was cross sectional study with purposive sampling methode involving 92 adult women in Sambirejo village, Mantingan, Ngawi, East Java. Anthropometric assessments consisted of BMI, waist circumference, and waist-hip ratio. Data analysis consisted of univariate and bivariate using Pearson Product Moment. Bivariate analysis was performed by the correlation of anthropometric assessment with total cholesterol levels. The results showed that 15.2% subjects were overweight and 54.1% subjects had obesity. There were 80,4 % subjects had waist circumference 80 cm and 71,7% subjects had waist-hip ratio ≥0,85. Subjects with cholesterol levels 200 mg / dL were 31,5 %. The BMI and waist circumference had no correlation to total cholesterol level. The waist-hip ratio had a significant correlation to cholesterol level. The conclusion of this study was waist-hip ratio in women related to high total cholesterol level.Penelitian ini bertujuan menganalisis hubungan penilaian antropometri dengan kadar kolesterol total pada wanita dewasa. Desain penelitian adalah studi potong lintang dengan melibatkan sebanyak 92 orang wanita dewasa. Sampel dipilih secara purposive sampling di desa Sambirejo Kecamatan Mantingan Kabupaten Ngawi Jawa Timur. Penilaian antropometri yang dilakukan meliputi IMT, lingkar pinggang dan rasio lingkar pinggang-pinggul. Analisis data terdiri atas univariat dan bivariat  melalui uji Pearson Product Moment untuk melihat korelasi hasil penilaian antropometri dengan kadar kolesterol total. Hasil penelitian menunjukkan bahwa 15,2% dan 54,1% subjek memiliki status gizi lebih dan obesitas. Sebanyak 80,4 % memiliki lingkar pinggang 80 cm dan sebanyak 71,7% memiliki rasio lingkar pinggang dan pinggul ≥0,85. Subjek dengan kadar kolesterol  200 mg/dL sebanyak 31,5%. Hasil penelitian menunjukkan bahwa IMT dan lingkar pinggang tidak berkaitan dengan kadar kolesterol total. Rasio lingkar pinggang-pinggul berhubungan signifikan (p-value=0,29; r=0,227) dengan kadar kolesterol. Kesimpulan dari penelitian ini adalah rasio lingkar pinggang-pinggul pada wanita berkaitan dengan tingginya kadar kolesterol total.
PENYULUHAN MENGENAI CUCI TANGAN DAN PENGGUNAAN HANDSANITIZER UNTUK MENCEGAH INFEKSI COVID-19 Marfu'ah, Nurul; Kusumaningtyas, Nadia Mira; Awaluddin, Rizki; Kurniawan, Kurniawan
Jurnal Pengabdian Masyarakat Bumi Raflesia Vol 4, No 3 (2021): Jurnal Pengabdian Masyarakat Bumi Raflesia
Publisher : Universitas Muhammadiyah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36085/jpmbr.v4i3.1709

Abstract

Berkembangnya wabah Corona Virus Disease-19 (COVID-19) di dunia hingga ke Indonesia, sangat mengkhawatirkan seluruh lapisan masyarakat. salah satu cara yang dilakukan untuk mencegah infeksi Covid-19 adalah dengan mencuci tangan dan menggunakan handsanitizer. Banyak masyarakat yang belum memahami bagaimana cara mencuci tangan dan menggunakan handsanitizer yang baik dan benar. Oleh karena itu, kegiatan ini dilakukan dengan memberikan penyuluhan mengenai cuci tangan dan pelatihan penggunaan handsanitizer. Responden adalah karyawan UNIDA Gontor Kampus Putri Mantingan, Ngawi sebanyak 31 orang. Sebelum dan sesudah penyuluhan dan pelatihan, responden diberi pre test dan post test untuk mengukur tingkat pengetahuan dan keterampilan responden. Hasil kegiatan menunjukkan bahwa sebelum penyuluhan dan pelatihan, tingkat pengetahuan dan keterampilan responden mengenai cuci tangan dan penggunaan handsanitizer terdiri atas Sangat Baik (67,7 %) dan Baik (32,3 %). Sedangkan setelah penyuluhan dan pelatihan, 100 % responden mengetahui dengan Sangat Baik mengenai cuci tangan dan penggunaan handsanitizer yang baik dan benar. Kegiatan penyuluhan mengenai cuci tangan dan pelatihan penggunaan handsanitizer dapat meningkatkan pengetahuan dan keterampilan responden (karyawan) mengenai hal tersebut. Hal ini diharapkan dapat menghindarkan responden dari infeksi covid-19 dan meningkatkan kesehatan para karyawan.
PENGARUH STEROID ANABOLIK METHANDIENONE TERHADAP KUANTITAS SPERMATOZOA TIKUS PUTIH (Rattus norvegicus) Nurul Marfu'ah; I Wayan Kasa; Sagung Chandra Yowani
Jurnal Biologi Udayana Vol 18 No 1 (2014): Jurnal Biologi
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.2 KB)

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh steroid anabolik methandienone terhadap kuantitas spermatozoa tikus putih (Rattus norvegicus). Pemeriksaan kuantitas spermatozoa dilakukan pada testis dan epididimis kauda. Testis dibuat sebagai sediaan preparat dengan metode parafin dan pewarnaan Hematoxylin-Eosin kemudian dilakukan penghitungan jumlah spermatogonia, spermatosit, dan spermatid. Penghitungan jumlah spermatozoa epididimis kauda dilakukan berdasarkan prosedur WHO dalam Syamrizal (1995). Hasil penelitian menunjukkan bahwa rerata kuantitas spermatozoa antara kelompok kontrol dan kelompok perlakuan secara statistik tidak berbeda nyata (P>0,05). Meskipun demikian, rerata kuantitas spermatozoa menunjukkan kecenderungan menurun. Hal ini ditunjukkan oleh rerata jumlah spermatogonia yang mengalami kecenderungan menurun pada dosis 6 dan 12 mg/kg bb. Rerata jumlah spermatosit antar kelompok perlakuan juga menunjukkan kecenderungan menurun. Begitu pula rerata jumlah spermatid dan spermatozoa juga menunjukkan kecenderungan menurun.
POTENSI INFUSA DAUN OKRA (Abelmoschus esculentus L. Moench) TERHADAP PENURUNAN KADAR GLUKOSA DARAH MENCIT-INDUKSI ALOKSAN Eva Nor Diana Lestari; Rahmat A Hi Wahid; Nurul Marfu'ah
Media Farmasi: Jurnal Ilmu Farmasi Vol 17, No 1: Maret 2020
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.516 KB) | DOI: 10.12928/mf.v17i1.14397

Abstract

Diabetes melitus (DM) merupakan suatu penyakit yang ditandai dengan tingginya kadar glukosa dalam darah. Kandungan kimia pada tanaman okra di antaranya 67,50% α-selulosa, 15,40% hemiselulosa dan flavonoid yang berefek antidiabetes. Tujuan penelitian untuk mengetahui potensi infusa daun okra terhadap penurunan kadar glukosa darah mencit (Mus musculus) yang diinduksi aloksan. Metode penelitian yang digunakan adalah eksperimental dengan desain Rancangan Acak Lengkap (RAL). Penelitian ini menggunakan 20 ekor mencit jantan berusia tiga bulan yang diinduksi diabetes menggunakan aloksan dan dibagi ke dalam lima kelompok. (1) Kelompok kontrol negatif, diberi aquades, (2) Kelompok kontrol positif, diberi glibenklamide dosis 3 mg/KgBB, dan kelompok (3-5) diberi infusa daun okra dengan dosis 0,2, 0,4, dan 0,6 mL/hari selama 14 hari. Pengukuran kadar glukosa dilakukan setelah 14 hari perlakuan menggunakan glukometer (Easy Touch® GCU). Analisis data menggunakan uji One Way ANOVA dengan tingkat signifikansi 95% (p=0,05). Hasil penelitian menunjukkan infusa daun okra dosis 0,2, 0,4, dan 0,6 mL/hari menurunkan kadar glukosa darah namun tidak bermakna secara statistik p=0,990 (p>0,05). Hasil penelitian dapat disimpulkan bahwa pemberian infusa daun okra dosis 0,2, 0,4, dan 0,6 mL/hari berpotensi menurunkan kadar glukosa darah mencit terinduksi aloksan tetapi tidak signifikan.
Rasio Lingkar Pinggang-Pinggul dan Kaitannya dengan Kadar Kolesterol Total pada Wanita Dewasa Susi Nurohmi; Nurul Marfu'ah; Mira Dian Naufalina; Siti Awalisanah Hani Farhana; Muhammad El Riza
Nutri-Sains: Jurnal Gizi, Pangan dan Aplikasinya Vol 4, No 1 (2020)
Publisher : Universitas Islam Negeri Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/ns.2020.4.1.4706

Abstract

This study aimed to analyze the association between anthropometric assessments and total cholesterol levels among adult women. The research design was cross sectional study with purposive sampling methode involving 92 adult women in Sambirejo village, Mantingan, Ngawi, East Java. Anthropometric assessments consisted of BMI, waist circumference, and waist-hip ratio. Data analysis consisted of univariate and bivariate using Pearson Product Moment. Bivariate analysis was performed by the correlation of anthropometric assessment with total cholesterol levels. The results showed that 15.2% subjects were overweight and 54.1% subjects had obesity. There were 80,4 % subjects had waist circumference 80 cm and 71,7% subjects had waist-hip ratio ≥0,85. Subjects with cholesterol levels 200 mg / dL were 31,5 %. The BMI and waist circumference had no correlation to total cholesterol level. The waist-hip ratio had a significant correlation to cholesterol level. The conclusion of this study was waist-hip ratio in women related to high total cholesterol level.Penelitian ini bertujuan menganalisis hubungan penilaian antropometri dengan kadar kolesterol total pada wanita dewasa. Desain penelitian adalah studi potong lintang dengan melibatkan sebanyak 92 orang wanita dewasa. Sampel dipilih secara purposive sampling di desa Sambirejo Kecamatan Mantingan Kabupaten Ngawi Jawa Timur. Penilaian antropometri yang dilakukan meliputi IMT, lingkar pinggang dan rasio lingkar pinggang-pinggul. Analisis data terdiri atas univariat dan bivariat  melalui uji Pearson Product Moment untuk melihat korelasi hasil penilaian antropometri dengan kadar kolesterol total. Hasil penelitian menunjukkan bahwa 15,2% dan 54,1% subjek memiliki status gizi lebih dan obesitas. Sebanyak 80,4 % memiliki lingkar pinggang 80 cm dan sebanyak 71,7% memiliki rasio lingkar pinggang dan pinggul ≥0,85. Subjek dengan kadar kolesterol  200 mg/dL sebanyak 31,5%. Hasil penelitian menunjukkan bahwa IMT dan lingkar pinggang tidak berkaitan dengan kadar kolesterol total. Rasio lingkar pinggang-pinggul berhubungan signifikan (p-value=0,29; r=0,227) dengan kadar kolesterol. Kesimpulan dari penelitian ini adalah rasio lingkar pinggang-pinggul pada wanita berkaitan dengan tingginya kadar kolesterol total.
Aktivitas Larvasida Fraksi N-Heksan Ekstrak Etanol Daun Mengkudu (Morinda citrifolia. L) terhadap Larva Aedes sp. Rizki Awaluddin; Binti Sholihatin; Nurul Marfu'ah; Solikah Ana Estikomah
ASPIRATOR - Journal of Vector-borne Disease Studies Vol 13 No 2 (2021): Jurnal Aspirator Volume 13 Nomor 2 2021
Publisher : Loka Litbang Kesehatan Pangandaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (818.358 KB) | DOI: 10.22435/asp.v13i2.4823

Abstract

Abstract. Aedes sp. is a vector of the dengue virus that causes Dengue Hemorrhagic Fever (DHF).Larvicides are the optimal method for controlling mosquito development. Temephos is a larvicidalagent of the organophosphate group which is reported to cause side eff ects and ecological hazards,as well as resistance based on reports in several country. This study aims to determine the larvicidalactivity of the n-hexane fraction of Morinda citrifolia leaf ethanol extract on Aedes sp. The compoundgroups in the fraction were identifi ed using TLC through UV light and spray reagents. There were sixtypes of treatment including four concentration fractions (400, 600, 800, and 1000 ppm) as treatment,positive control (temephos 1%) and negative control 1% acetone solution. Twenty-fi ve mosquito larvaeof Aedes sp. tested for each treatment. Larval mortality was recorded and LC50 and LC99 values wereanalyzed using the probit. The results showed that the TLC test of the n-hexane fraction was positivefor terpenoids, anthraquinones, phenols, tannins, and fl avonoids. The results showed that the LC50 andLC99 values were 1040 ppm and 2439 ppm. Therefore, the n-hexane fraction of the ethanol extract hadlarvicidal activity on Aedes sp with li le toxicity.
Aktivitas Antibakteri Kayu Siwak (Salvadora persica) Fraksi Eter terhadap Bakteri Staphylococcus aureus Secara In Vitro Riza Amalia; Nurul Marfu'ah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (635.984 KB) | DOI: 10.21111/pharmasipha.v2i1.2132

Abstract

Using miswak is one of sunnah performed by Prophet Muhammad SAW and it contains a variety of compounds including these terpenoids, alkaloids, tannins and flavonoids which function as an antibacterial on the periodontal disease. Therefore, extraction and fractionation process were done to get the active compounds in miswak wood that has antibacterial activity against Staphylococcus aureus. This study is an experimental research with Complete Random Design methods. Ethanol extract separated using miswak from solvent of ether. Screening phytochemicals on thin Layer Chromatography (TLC) and test tube, the antibacterial activity was done using diffusion method with a concentration of 50% v/v, 25% v/v, 12.5% v/v and 6.25% v/v, metronidazole as a positive control and a DMSO as the negative control. The data obtained were then analyzed using One Way ANOVA test. Wood of miswak from ether fraction provide inhibition of 14.6-20.8 mm included strong category. The use of metronidazole as positive controls provide significant inhibitory against Staphylococcus aureus and the solvent DMSO as a negative control did not provide any inhibitory area. As for the description of the zone of inhibition against Staphylococcus aureus bacteria. Miswak wood from ether has antibacterial activity against Staphylococcus aureus with fraction of ether concentration of 12.5% v/v and smallest zone amounting 14.6 mm. Whereas at the greatest concentration found in the inhibition of 50% v/v with the average diameter of the zone of drag of 20.8 mm, with secondary metabolites contained in miswak fraction of ether is these terpenoids, alkaloids and tannins
Co-Authors Al Hasanah, Fauziyyah Alifya Nur Azizah Amal Fadholah Amala, Nur Amilia Yuni Damayanti Ananda, Mutiara Andi Sri Suriati Amal Andri Karin, Elsy Juni Anugerah Suciati Astuti, Eti Aural Miftahul Hasanah Ava Zaujah Awaluddin, Rizki Ayu, Gustin Swastika Azzahra, Isma Chelsea Aulia Ramadhani Cisilliya Tandraini Damayanti, Widya Dewi Ratnasari Diah Ayu Mutmaina Dianti Desita Sari Eva Nor Diana Lestari Fajri, Mathla’il Fardyatullail, Haila Farhana, Siti Awalisanah Hani Fauziatunnisa, Elok Fazriah D., Gita Fitrian, Ahyana Frida SA, Yuna Hafifah, Cut Ajma Fitira Hamzah Gita Sari Hartinah Yulianto, Siti Haryanto, Qurrah A'yuniyyah I Wayan Kasa Ichwanuddin Ichwanuddin Indah Tri Lestari Indahtul Mufidah Khodijah, Alisya Khomarul Kuniyati Kurniawan Kurniawan Kurniawan Kurniawan, Kurniawan Kusumasary, Dhiyah Ayu KW, Faradhita Lestari, Eva Nor Diana Lia, Melda Lija Oktya Artanti Lija Oktya Artanti Lutfi Shantia Luthfiya, Lulu' Luthfiya, Lulu’ Mafazatien Nailiyah Isna Mahirotun NS, Anggun Mahmudah, Amalia Nurul Mahmudah, Hilma Radhia Mathlail Fajri Maulia Isnaini MIFTAKHUL JANNAH Mira Dian Naufalina Mira Dian Naufalina Muhammad El Riza NA, Eldyamarta Nadia Iha Fatihah Nadia Mira Kusumaningtyas Nadia Saptarina Nadia Saptarina Nida Faradisa Fauziyah Nisrina, Salma Nur Hazlia, Syarifah Pertamana, Ropia Pibriyanti, Kartika Pratiwi, Arika Putri Qurrah A'yuniyyah Haryanto Rabbaniyah, Muthi’ah Rahmat A Hi Wahid Rahmat A.H. Wahid Rauf, Ichsan Riyani, Retno Indra Riza Amalia Riza, Muhammad El Rizka Safira Rizki Awaluddin Rizki Awaluddin Rizky Dila Khairunnisa Rohmah Madya Ayu Fitriana Sagun Chandra Yowani Salma, Rahimia Nuzula Sari, Dianti Desita Satwika Budi Sawitri Sawitri, Satwika Budi Sha’sha’ Luthfiana Shifa Syururin, Wakhidatus Sholihatin, Binti Siska Fatkhul Hidayati Siska, Awenda Siti Awalisanah Hani Farhana Sitti Hijraini Nur Solikah Ana Estikomah Sujiat Zubaidi Sulikhah, Novia Anggreani Surya Amal Susi Nurohmi Tri Harianto Wafa Aufia Wahid, Rahmat A Hi Wahid, Rahmat A Hi Widayanti, Erna Desi Widyaratna, Indriyanti Winati, Dian Eska Yulia Dwi Andarini Yuwono, Ratna Rahajeng Putri Zulianita Zulianita Zulvia Faridatul Munawaroh