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All Journal Makara Journal of Science Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Budiarman, Andi Azizah Maulidia
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Molecular Docking of the Interaction between Citrus amblycarpa Extract Contents and Inflammatory Proteins of Hepatic Steatosis Rosida, Lena; Pratiwi, Dewi Indah Noviana; Panghiyangani, Roselina; Utami, Juliyatin Putri; Idhafi, Nasrul; Febriansyah, Muhammad; Budiarman, Andi Azizah Maulidia
Makara Journal of Science Vol. 28, No. 2
Publisher : UI Scholars Hub

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Abstract

Citrus amblycarpa possesses various pharmacological activities, such as antioxidant, anticancer, antitumor, hepatoprotective, anti-inflammatory, antidiabetic, antiviral, antibacterial, and antifungal. The main active compounds in C. amblycarpa (including gamma (γ)-aminobutyric acid [GABA], hesperidin, naringin, neoeriocitrin, poncirin, quercetin, and rutin) show potential to interact with the inflammatory proteins in hepatic steatosis (such as nuclear factor kappa beta [NF-kB], tumor necrosis alpha [TNF-alpha], interleukin-6 [IL-6], c-Jun NH2-terminal kinase [JNK], and adiponectin). Molecular docking simulations were performed using Swiss Dock (http://www.swissdock.ch/), and analysis and visualization were conducted using Discovery Studio 4.1. Rutin, poncirin, hesperidin, and neoeriocitrin exhibit high affinities to NF-κB, TNF-alpha, IL-6, and adiponectin proteins, respectively. Similar to curcumin–adiponectin complex interaction, neoeriocitrin–adiponectin interaction involves GLY 223, PRO41, and VAL93 residues. Thus, the most potent inhibitor of hepatic sterosis marker was neoeriocitrin.
GAMBARAN TINGKAT PENGETAHUAN MAHASISWA PSKPS FK ULM ANGKATAN 2020 TENTANG FAKTOR RISIKO NOISE-INDUCED HEARING LOSS (NIHL) Budiarman, Andi Azizah Maulidia; Asnawati, Asnawati; Huldani, Huldani; Kaidah, Siti; Rahmiati, Rahmiati
Homeostasis Vol 7, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i2.13178

Abstract

Abstract: A study conducted among 2020 cohort students at the Faculty of Medicine, ULM, aimed to evaluate their understanding of Noise-Induced Hearing Loss (NIHL) risk factors. NIHL, a hearing impairment caused by prolonged exposure to loud noise, is increasingly prevalent among adolescents due to excessive electronic media use. Employing a descriptive approach with a cross-sectional design, the study utilized total sampling, involving 154 respondents. Data collection relied on questionnaires and analysis via Microsoft Excel. Results indicated that 55.8% of participants had moderate knowledge, 40.2% demonstrated good understanding, and 3.8% exhibited poor knowledge about NIHL risk factors. The average knowledge score was 72.13, placing it in the moderate category. This denotes an overall moderate level of awareness among the students. In conclusion, the research highlighted the prevailing moderate understanding among the 2020 cohort students at the Faculty of Medicine, ULM, regarding NIHL risk factors. The findings emphasize the need for increased education and awareness programs to address this concerning issue, particularly among young individuals frequently exposed to potentially harmful noise from electronic devices. Keywords: Knowledge Level, medical students, NIHL. Abstrak: Noiced-Induced Hearing Loss (NIHL) merupakan gangguan pendengaran dan ketulian akibat terpajan bising yang cukup keras dalam jangka waktu yang lama. Pada remaja, penggunaan media elektronik yang berlebihan menjadi penyebab utama terjadinya NIHL. Penelitian ini bertujuan untuk mengetahui gambaran tingkat pengetahuan mahasiswa PSKPS FK ULM angkatan 2020 tentang faktor risiko Noise-Induced Hearing Loss (NIHL). Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional. Pemilihan sampel menggunakan teknik total sampling, didapatkan 154 orang responden. Teknik pengumpulan data menggunakan kuesioner. Data diolah menggunakan Microsoft Excel. 55.8% responden memiliki tingkat pengetahuan yang cukup, 40.2% responden memiliki tingkat pengetahuan yang baik, dan 3.8% responden memiliki tingkat pengetahuan yang kurang. Rata-rata nilai pengetahuan responden adalah 72.13 yang termasuk kategori Dapat disimpulkan secara umum tingkat pengetahuan mahasiswa PSKPS FK ULM angkatan 2020 tentang faktor risiko Noise-Induced Hearing Loss (NIHL) tergolong dalam kategori cukup. Kata kunci: Tingkat pengetahuan, mahasiswa kedokteran, NIHL.
Co-Authors Asnawati Asnawati Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Febriansyah, Muhammad Huldani Huldani Idhafi, Nasrul Lena Rosida Rahmiati Rahmiati Roselina Panghiyangani Siti Kaidah Utami, Juliyatin Putri