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Encapsulation of Fe3O4 with amina modified silica Roswanda, Robby; Mujahidin, Didin
Jurnal Keramik dan Gelas Indonesia Vol 26, No 1 (2017): Jurnal Keramik dan Gelas Indonesia
Publisher : Balai Besar Keramik

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2765.496 KB)

Abstract

Superparamagnet iron oxide Fe3O4 particles were encapsulated with amina modified silica via Stober Method. The particles generated were rod-like whose length was c.a. 2 µm and the thickness of silica shell was c.a. 75 nm. Magnetization measurements show that the silica shell does not disrupt the superparamagnetic property of Fe3O4. The amine group on the encapsulated particles was confirmed by attaching FITC (Fluorescein isothiocyanate) dye and checked under fluorescence microscope. The encapsulated particle is useful to be modified further for various applications that need magnetic field control.
Encapsulation of Fe3O4 with amina modified silica Robby Roswanda; Didin Mujahidin
Jurnal Keramik dan Gelas Indonesia Vol 26, No 1 (2017): Jurnal Keramik dan Gelas Indonesia
Publisher : Balai Besar Keramik

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2765.496 KB) | DOI: 10.32537/jkgi.v26i1.3915

Abstract

Superparamagnet iron oxide Fe3O4 particles were encapsulated with amina modified silica via Stober Method. The particles generated were rod-like whose length was c.a. 2 µm and the thickness of silica shell was c.a. 75 nm. Magnetization measurements show that the silica shell does not disrupt the superparamagnetic property of Fe3O4. The amine group on the encapsulated particles was confirmed by attaching FITC (Fluorescein isothiocyanate) dye and checked under fluorescence microscope. The encapsulated particle is useful to be modified further for various applications that need magnetic field control.
Encapsulation of Fe3O4 with amina modified silica Robby Roswanda; Didin Mujahidin
Jurnal Keramik dan Gelas Indonesia Vol 26, No 1 (2017): Jurnal Keramik dan Gelas Indonesia
Publisher : Balai Besar Keramik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32537/jkgi.v26i1.3915

Abstract

Superparamagnet iron oxide Fe3O4 particles were encapsulated with amina modified silica via Stober Method. The particles generated were rod-like whose length was c.a. 2 µm and the thickness of silica shell was c.a. 75 nm. Magnetization measurements show that the silica shell does not disrupt the superparamagnetic property of Fe3O4. The amine group on the encapsulated particles was confirmed by attaching FITC (Fluorescein isothiocyanate) dye and checked under fluorescence microscope. The encapsulated particle is useful to be modified further for various applications that need magnetic field control.
A Straightforward Selective Acylation of Phenols over ZSM-5 towards Making Paracetamol Precursors Robby Roswanda; Alfhons Daniel Sirampun; Rino Rakhmata Mukti; Didin Mujahidin
Bulletin of Chemical Reaction Engineering & Catalysis 2018: BCREC Volume 13 Issue 3 Year 2018 (December 2018)
Publisher : Masyarakat Katalis Indonesia - Indonesian Catalyst Society (MKICS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.9767/bcrec.13.3.2856.573-587

Abstract

Commercially available ZSM-5 was minimally treated as the catalyst to selectively acylate phenols. The ZSM-5 was simply immersed in ammonium nitrate in order to fill the pores with Brönsted acid to concentrate the catalytic reactions inside the pores. The reactions were carried out in liquid phase at 383 K. Acetic acid and propionic acid were chosen as the acyl substrate. Gas chromatography reveals two products which are phenyl acetate and almost exclusively para-hydroxyacetophenone meaning no ortho product observed. This para selectivity can be attributed to the pores of ZSM-5 where the reaction is assumed to be happening via intermolecular reaction. It is a relatively straightforward method in making para-hydroxyacetophenone which is known as paracetamol precursor. 
Discovery of thymol-fused chalcones as new competitive \(\alpha\)-glucosidase inhibitors: Design, synthesis, biological evaluation, and molecular modeling studies Danova, Ade; Hermawati, Elvira; Chavasiri, Warinthorn; Mujahidin, Didin; Alni, Anita; Roswanda, Robby
Communications in Science and Technology Vol 9 No 2 (2024)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.9.2.2024.1497

Abstract

This study aims to synthesize and evaluate the inhibitory activity of thymol derivatives targeting ?-glucosidase using in vitro and in silico studies. Ten thymol derivatives (2-11) including five new thymol-fused chalcones (7-11) were successfully synthesized. Among them, four compounds (4, 8, 9, 11) showed the best inhibitory activity with IC50 values of 18.45, 13.75, 8.86, and 10.67µM compared with acarbose (IC50 = 832.82 µM), respectively. The kinetic study of three new thymol-fused chalcones (8, 9, 11) exhibited a competitive inhibition. Molecular docking demonstrated the predicted interactions between ligand (8, 9, 11) and ?-glucosidase, which are responsible for inhibiting the enzyme's catalytic abilities. Furthermore, molecular dynamics simulation of the enzyme-ligand 9 complex indicated that this complex was stable in aqueous condition. This research contributes significantly to the understanding of thymol-fused chalcones that may have therapeutic potential and their possible application in the treatment of type 2 diabetes mellitus (T2DM) for further study.
Intramolecular Oxa-Michael Cyclization of 2’-Hydroxychalcones for the Synthesis of Flavanones: A Comparative Study Ramadhini, Rizky Annisa; Danova, Ade; Roswanda, Robby
Science and Technology Indonesia Vol. 10 No. 4 (2025): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.4.1169-1178

Abstract

In this study, flavanones were synthesized using a two-step reaction process starting from 2’ hydroxyacetophenone and aldehydes. Claisen-Schmidt condensations were carried out on the starting materials to produce 2’-hydroxychalcones with mono-, di-, and tri-substituents on ring B. Subsequently, flavanones were produced via intramolecular oxa-Michael cyclization under three different reaction conditions: methanesulfonic acid in ethanol, sodium acetate in methanol, and piperidine in water. These approaches aimed to investigate the steric and electronic effects to achieve high yields in optimal reaction conditions for flavanone synthesis. Twelve 2’-hydroxychalcones (1a-1l) were successfully synthesized with yields ranging from 17% to 99%. The use of methanesulfonic acid in ethanol resulted in modest flavanone yields (11% for 2a, 13% for 2c). The synthesis of flavanones using sodium acetate was successful for seven 2’-hydroxychalcones (2a-2g), yielding products with varying yields (2-49%). Furthermore, piperidine was effective for three 2’-hydroxychalcones (1a, 1b, 1e), resulting in high flavanone yields (74-93%). These findings indicate that the three reaction conditions are only effective for certain 2’-hydroxychalcones.