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All Journal Journals of Ners Community Sumatera Medical Journal
Keumala Sari, Dina
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Immunology & microbiology Medicine & Pharmacology Nursing

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Journal : Sumatera Medical Journal

 1 
Diets That Have Potential to Stimulate the Hypothalamic-Pituitary-Adrenal (HPA) Axis in Sprague Dawley Rats Khairil Azwan; Mona, Resni; Firdous, Jannathul; Rosie David, Pamela; Keumala Sari, Dina; Muhammad, Noorzaid
Sumatera Medical Journal Vol. 6 No. 2 (2023): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v6i2.11650

Abstract

Background: The pituitary gland is the master gland regulating body hormones. From the anterior pituitary’s corticotrophs, adrenocorticotrophic hormone (ACTH) is secreted and influences corticosterone production in rodents via the hypothalamic–pituitary–adrenal (HPA) axis. ACTH and corticosterone are commonly used as hormonal stress markers. Disturbances in ACTH and corticosterone are seen in diseases like Addison’s disease, Cushing’s syndrome, and metabolic syndrome. Objective: To observe which diet induces the most and least stress on Sprague Dawley rats’ physiology. Methods: Thirty-five Sprague Dawley rats were divided into five groups (n=7) and given different diets (control, high-fat, high-protein, high-sugar, and high-starch) with tap water ad libitum. After eight weeks, blood samples were collected and serum separated. ACTH and corticosterone were extracted, purified, identified, and quantified using High-Performance Liquid Chromatography (HPLC) with photodiode array (PDA) analysis. Results: High-sugar diet led to the highest ACTH blood level. Both high-fat and high-sugar diets showed the highest corticosterone peaks. Conclusion: Consumption of high-fat and high-sugar diets for eight weeks is suggested to induce physiological and metabolic stress in Sprague Dawley rats, as evidenced by HPA axis activation.
Subacute Toxicity of Yellow Flower Extract (Cananga odorata) on the Histopathology of White Rat Heart (Rattus norvegicus) Mani, Suresh; Akbari Ganie, Ratna; Keumala Sari, Dina; Meutia Sari, Liza; Rachmawati, Meike; Muhammad, Noorzaid
Sumatera Medical Journal Vol. 6 No. 2 (2023): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v6i2.11931

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Background: The inflammatory process is influenced by chemical mediators such as Nitric Oxide (NO), cytokines, and arachidonic acid metabolites. The therapeutic effect of herbal plants comes from phytochemicals with strong antioxidant activity. Objective: To examine the phytochemical content and anti-inflammatory effects of Cananga odorata. Methods: This was a two-stage study: in vitro and in vivo. Anti-inflammatory activity is related not only to antioxidant properties but also to suppression of nitric oxide and pro-inflammatory cytokines. This effect is being explored using various herbal plants. One such plant is Cananga odorata (ylang flower), a tropical plant with fragrant petals that grows easily. Results: The total phenol content was 1.06% w/w. Antioxidant activity measured using DPPH method showed an IC50 of 808.86 ppm, indicating weak antioxidant activity. In rats, the extract reduced blood glucose levels but had no effect on lipid profiles. Toxicity testing showed no toxic effects. Histological analysis showed no differences between cardiovascular disease model mice and standard-fed mice. Conclusion: The ethanol extract of Cananga odorata did not show toxicity in the heart histopathology of white rats.
The Relationships between Emotional Intelligence and Physical Activity Related to Gender among Undergraduates in the Colombo District Wijerathne, Tharindi; Keumala Sari, Dina; Liyanage , Thanuja; Liyanage , Lakshika
Sumatera Medical Journal Vol. 8 No. 3 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i3.20595

Abstract

Background: Emotions are dynamic aspects of human nature and serve as inspiration for behavior. Higher emotional intelligence (EI) is associated with greater resilience and lower levels of depression. Certain situations can increase physical activity (PA) among young people. This study examined gender differences in EI and PA among undergraduates at State Universities in Colombo District. Objective: To assess how emotional intelligence and physical activity differ between genders in this population. Methods: A descriptive, quantitative, correlational study was conducted with 397 undergraduates who completed the Wong and Low EI questionnaire and the International Physical Activity Questionnaire (IPAQ). Data analysis was performed using the Mann-Whitney U test. Results: Participants were from State Universities in Colombo District, mainly exhibiting moderate to low PA levels. Males showed significantly higher EI than females (z = -3.829, p = .001), while there was no significant difference in PA between genders (z = -.938, p = .348). Conclusion: Males demonstrate higher EI than females, but physical activity levels do not significantly differ by gender. Most participants had low to moderate PA levels, which can inform strategies for preventing non-communicable diseases among youth.
Co-Authors Akbari Ganie, Ratna Aprianti Lubis, Nenni Dwi Dwi Aprianti Lubis, Nenni Firdous, Jannathul Harahap, Juliandi Khairil Azwan Lita Sri Andayani Liyanage , Lakshika Liyanage , Thanuja Mani, Suresh Meike Rachmawati Meutia Sari, Liza Mona, Resni Muhammad, Noorzaid Rina Amelia Rosie David, Pamela Wijerathne, Tharindi