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All Journal CHEMPUBLISH JOURNAL Journal of The Indonesian Society of Integrated Chemistry Jurnal Kimia Unand
Syafrizayanti
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Materials Science & Nanotechnology

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Penentuan Kadar Astaxanthin, Uji Antiinflamasi Dan Sitotoksik Terhadap Sel Kanker Payudara Ekstrak Aseton Spirulina Platensis Armaini; Syafrizayanti; Zara Aulia
Jurnal Kimia Unand Vol. 11 No. 1 (2022): May 2022
Publisher : Departemen Kimia Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jku.11.1.25-32.2022

Abstract

Spirulina platensis is a microalgae widely used in the health sector due to its micronutrients, biopigment such as astaxanthin. Astaxanthin is carotenoid belonging to strong antioxidant, which has anti-inflammatory and cytotoxic effects on MCF-7 breast cancer cells. This study aims to determine astaxanthin contents, to investigate the anti-inflammatory activity and cytotoxic potential of breast cancer cells MCF-7 treated with acetone extract from Spirulina platensis. Extraction is done by maceration method. Astaxanthin contents were determined using UV-Vis spectrophotometer set to 479 nm. The anti-inflammatory assays were performed using inhibition of protein denaturation method and cytotoxic assays were performed using the MTT method. From results of study, the extract contained 6,3008 mg/L astaxanthin. The IC50 values for anti-inflammatory and cytotoxic tests ​​were 363,399 mg/L and 66,68 mg/L, respectively. According to the result of the tests, acetone extract from Spirulina platensis showed anti-inflammatory activity and moderate cytotoxic activity against MCF-7 breast cancer cells.
Detection and Absolute Quantification Porcine DNA in Sausages Using Quantitative Polymerase Chain Reaction (qPCR) Method Syafrizayanti; S. Safni; Nurhayati
Jurnal Kimia Unand Vol. 11 No. 2 (2022): November 2022
Publisher : Departemen Kimia Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jku.11.2.5-13.2022

Abstract

Identification of adulteration of processed meat products with unwanted ingredients is a crucial issue. These meat products are prone to forgery and mix with porcine. Meat source authentication is important for Muslim consumers to whom comsumption of products containing pork and its derivatives in an products is prohibited. This present study aims at development of detection and quantification method of porcine DNA (Deoxyribo Nucleic Acid) in processed meat products, sausages. Two novel primer pairs were designed specifically targeting fragment of Displacement Loop (D-Loop) and cytochrome b (cyt b) of porcine mitochondrial DNA and to generate 139 bp and 143 bp amplicons, respectively. Detection and quantification were accomplished by Quantitative Polymerase Chain Reaction (qPCR). Porcine DNA standard curves and cycle threshold were used for quantification. The detection limit of porcine DNA was as little as 0.05 pg. Of all sausages tested (n=13), four of them contained porcine DNA as much 3.1 pg; 0.160 pg; 0.294 pg; and 0.110 pg in 0.001 mg of sausages for J, G, I, and L samples respectively. The specific qPCR assay method can be used for the detection of porcine DNA in minute amounts, which can be used for the halal authentication of food and pharmaceutical products.
Potential Toxicity of Legundi Leaf Extract (Vitex Trifolia L) Using the Brine Shrimp Lethality Test (BSLT) Method Arifah, Zil; Efdi, Mai; Syafrizayanti
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.33115

Abstract

Many natural products can be used as starting points in developing modern medicines because of their capabilities in pharmacological activities. Vitex trifolia L is an herbal plant that has been used to treat diseases such as fever, inflammation, colds, irregular menstruation, and diseases related to the female reproductive organs. This study aims to identify the cytotoxic ability of Vitex trifolia L leaf extract using the Brine Shrimp Lethality Test (BSLT) method. Extraction was carried out by maceration and fractionation methods, followed by phytochemical assay and cytotoxic assay using BSLT method. The results showed that the n-hexane extract had a moderate cytotoxic effect (LC50 241 µg/ml), the methanol extract included in the low toxic category (LC50 995 µg/ml) and the other two extracts involved in the non-toxic category (ethyl acetate and butanol).
Review: Melastoma malabathricum Natural Compounds as Inhibitors of Resistant Bacterial Development Susanti, Febria Elvy; Efdi, Mai; Syafrizayanti; Septama, Abdi Wira
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.41114

Abstract

The abundance of natural medicines in nature is very capable of being used and developed in various lives both individually and in combination in the modern medical field. Various developments and treatments as well as the discovery of new concepts will be able to interact with human physiology. One plant that has the potential to be developed is Melastoma malabathricum, also known as senduduk. This plant from the Melastomataceae family is easily found in tropical Asia and has long been used as an herb in traditional Chinese medicine. Based on the data collected, various studies have shown the pharmacological bioactivity of Melastoma malabathricum which has antibacterial potential and is able to fight resistant bacteria. Chemicals in this plant, including flavonoids, terpenoids, alkaloids, and steroids have been detected and shown to be inhibitors of bacterial growth, including resistant bacteria.
Co-Authors Abdi Wira Septama Arifah, Zil Armaini Mai Efdi Nurhayati S. Safni Susanti, Febria Elvy Zara Aulia