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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) International Journal of Islamic Education, Research and Multiculturalism (IJIERM)
Veranyca Chiuman
Universitas Prima Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Materials Science & Nanotechnology Physics Other

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Anti-inflammatory Activity of Lemon Pepper Nanoemulsion on Carrageenan-Induced Male Wistar Rat Linda Chiuman; Dwi Putri Agita Sebayang; Veranyca Chiuman; Suhartomi Suhartomi
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6292

Abstract

Lemon pepper does not only have a unique taste but also has some active compounds, which has anti-inflammatory activity. This study intended to investigate the anti-inflammatory effect of lemon pepper nanoemulsion on carrageenan-induced Wistar rats. This experimental study used Twenty-five male Wistar rats that were grouped into five different groups, including control, standard, lemon pepper nanoemulsion dose of 25, 50, and 75 mg/ kgBW. Initially, all rats received air injection in the back area for 5 days to form an air pouch. After that, all rats were injected with 1% carrageenan solution, and received treatment based on the groups for 48 hours via oral route. Then, it counted the number of white blood cells by Giemsa Stain that was expressed as a number of cells per High Power Field (HPF). The increasing of Lemon pepper nanoemulsion dose significantly decreased the number of leucocytes in the carrageenan aspiration after 48 hours of treatment (P-Value < 0.001). The lowest number of leucocytes was found in the Lemon Pepper Nanoemulsion dose of 75 mg/kgBW (2.40 leukocytes per HPF). Hence, it can be deducted that the lemon pepper nanoemulsion has an anti-inflammatory effect, especially at a dose of 50-75 mg/kgBW.
THE EFFECT OF ETHANOL EXTRACT OF ZIZIPHUS MAURITIANA LAM. LEAF ON ALLOXAN-INDUCED RAT Tcanty Indrianti; Ali Napiah Nasution; Evelyn Angie; Clarissa Lister; Veranyca Chiuman
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 6 No 2 (2024): International Journal of Islamic Education, Research and Multiculturalism (IJIERM
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v6i2.348

Abstract

Bidara (Ziziphus mauritiana Lam.) or Indian jujube or ber is one Indonesian endemic plant which widely used as a traditional remedy in Indonesia and other Asian countries. Bidara leaves are commonly used as a remedy for diarrhea, liver diseases, and diabetes. This study aims to determine the effect of ethanol extract of bidara leaves (Z. mauritiana Lam.) on alloxan-induced male Wistar strain rat’s (Rattus norvegicus) liver. This is an experimental study with a randomized pretest-posttest with a control group design. This study involved 24 male Wistar strain rats (R. norvegicus) which were divided into 6 separate groups induced with alloxan and each group received a different intervention accordingly. Data in this study shows that ethanol extract of bidara leaves contains alkaloids, saponins, flavonoids, and glycoside compounds. This study also found that ethanol extract of bidara leaves at doses as low as 150 mg/kgBW managed to decrease the blood glucose, SGOT, and SGPT levels better than negative control and as effective as metformin. Escalation of SOD activity was also found to be directly proportional to dose increase, however, the highest concentration of MDA was also found in the highest dose of ethanol extract of bidara leaves. It can be concluded that ethanol extract from bidara leaves has anti-hyperglycemic (p<0.001) and hepatoprotective (p<0.05) effects, but the antioxidant properties cannot be determined according to this study’s data.
Co-Authors Ali Napiah Nasution Clarissa Lister Dwi Putri Agita Sebayang Evelyn Angie Linda Chiuman Suhartomi Tcanty Indrianti