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ANTI-BACTERIAL ACTIVITY OF ETHANOL EXTRACT OF INDIAN BORAGE (Coleus Amboinicus) LEAVES AGAINST BACILLUS CEREUS Mutia, Maya Sari; Annisa, Elvia; Suhartomi, Suhartomi
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 7 No. 1 (2021)
Publisher : Universitas Tadulako

Bacillus cereus is aerobic, positive gram, and spore-forming bacilli bacteria. The enterotoxin of this bacteria can cause food poisonous that manifest as diarrhea and vomitus. Some previous study has been performed to explore the antibacterial effect of Indian borage leaf, but none of them were explore the antibacterial effect of Indian borage against Bacillus cereus. Hence this study was design to explore the antibacterial activity of ethanol extract of Indian borage against Bacillus cereus. This was an experimental study with post only control group design. Ethanol extract was extracted by maceration methods and antibacterial activity against Bacillus cereus was evaluated by disc diffusion methods. The obtained ethanol extract was dissolved into some concentraions (1 g/ml, 0.8 g/ml, 0.6 g/ml, 0.4 g/ml, 0.2 g/ml). Data was analysed by One Way ANOVA and followed by Post hoc Test Tukey HSD using SPSS 25. Ethanol extract of Coleus amboinicus showed significant difference at the two highest concentration group against the lowest concentration (P- Value < 0.05). The average of inhibition zone diameter from the lowest (0.2 gr/ml) and highest (1.0 gr/ml) concentration were 14.87 mm and 31.50 mm, respectively. Overall, ethanol extract of Indian borage leaves had potential antibacterial activity against Bacillus cereus. This antibacterial activity increase followed by the increase of the concentration.

PENGARUH KEBIASAAN MEROKOK TERHADAP KEJADIAN HIPERTENSI DI RUMAH SAKIT MELATI PERBAUNGAN BRAWA TAMA UNSANDY; SUHARTOMI .
JURNAL ILMIAH MAKSITEK Vol 7 No 1 (2022): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Based on the 2018 Basic Health Research (RISKESDAS), the prevalence of hypertension based on a doctor diagnosis is8.4%. Meanwhile, based on the results of direct measurements of the population aged over 18 years, the prevalence ofhypertension is 34.1%. Therefore, it become important to identify modifiable risk factors. One of them is smoking habit.The purpose of this study was to determine the relationship between smoking and hypertension among inpatients at theInternal Medicine Outpatient Clinic of Melati Perbaungan Hospital in 2020. This study used a cross-sectional design with astudy population of all male patients at the Outpatient Clinic. Fifty-two people were taken from the population by consecutivemethods. All data were then analyzed by SPSS 25 with univariate analysis and bivariate analysis (with chi square test).From this study, it was found that there was a statistically significant relationship between smoking habits (p=0.002), type ofcigarette (p=0.008), length of smoking (p=0.014), and smoking frequency (p=0.011) against hypertension. The activesmoking behavior (OR: 7.20 95% CI: 1.89-27.50), non-filtered cigarette type (OR: 10.80; 95% CI: 1.69-68.94), smokingduration > 20 years (OR: 13.50; 95% CI: 2.15 – 84.69), and the smoking frequency of 1-9 cigarettes/day (OR: 13.50; 95%CI: 2.15-84.69) increased risk of developing hypertension. Hence, it can be concluded that there was a relationship betweensmoking and the develop of hypertension.

HUBUNGAN ANTARA FREKUENSI MENGGUNAKAN ALCOHOL-BASED HAND RUB TERHADAP GAMBARAN KLINIS DERMATITIS KONTAK PADA TENAGA KESEHATAN DI RUMAH SAKIT MURNI TEGUH JOICE SONYA GANI PANJAITAN; SUHARTOMI .
JURNAL ILMIAH SIMANTEK Vol 5 No 3 (2021): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Health workers in operating rooms and Intensive Care Units show high incidence of contact dermatitis, which was 18% to57%. Contact dermatitis in health workers occurs because there are many irritants in hospitals, one of them was antisepticsuch as hand sanitizer or hand rub. This study aimed to evaluate the relationship between the frequency of alcohol-basedhand rub application and the clinical presentation of contact dermatitis in health workers during the COVID-19 pandemic.This study was an observational study with a cross-sectional design. This study was performed among 111 health workers atMurni Teguh Hospital Medan from November 2020-March 2021 who were selected by the purposive sampling method.Meanwhile, the data analysis used to analyze the relationship between the frequency of Alcohol-Based Hand Rub applicationand the clinical presentation of contact dermatitis was the Fisher Exact Test. The majority of health workers at Murni TeguhHospital Medan used alcohol-based hand rub more than 10 times/ day (97.3%). Meanwhile, the clinical presentation ofcontact dermatitis found in health workers from the most to the least was dry skin as many as 103 people (92.8%), followedby thickened skin as many as 92 people (82.9%), burning sensation in 90 people (81.1 %), redness and itching in 88 people(79.3%), and pain in only 84 people (75.7%). After statistical analysis of the frequency of hand rub application and clinicalpresentations of contact dermatitis, no significant relationship was found (P value > 0.05). The frequency of alcohol-basedhand rub application did not affect the clinical presentation of contact dermatitis in health workers at Murni Teguh Hospital.

HUBUNGAN ANTARA ASPEK KESEHATAN MENTAL DAN PERSEPSI TENTANG PEMBELAJARAN DARING TERHADAP INDEKS PRESTASI KUMULATIF MAHASISWA MAUPUN MAHASISWI DI FAKULTAS KEDOKTERAN HKBP NOMMENSEN JOICE SONYA GANI PANJAITAN; SUHARTOMI .
JURNAL ILMIAH SIMANTEK Vol 6 No 1 (2022): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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The pandemic has greatly impacted students, resulting in the lecture system that was originally face-to-face to online,moreover the harder task with anxiety about online study achievement. To evaluate the relationship between mental healthaspects and perceptions of online learning system on the grade point average (GPA) among students at the Faculty ofMedicine, Universitas HKBP Nommensen. This study is a cross-sectional study on 88 students at the Faculty of Medicine,Universitas HKBP Nommensen between October-November 2021, selected by the accidental sampling method. Aspects ofmental health (Depression, Anxiety, and Stress) and perceptions about online learning were evaluated by an onlinequestionnaire. Meanwhile, the statistical analysis used to achieve the research objectives was chi-square as bivariateanalysis and logistic regression as multivariate analysis. There was no significant relationship between anxiety, stress, andperceptions of online learning on the GPA of students at the Faculty of Medicine, Universitas HKBP Nommensen (P value >0.05). Interestingly, only depression significantly affected the GPA scores of students at the Faculty of Medicine, UniversitasHKBP Nommensen (P value < 0.05; OR [95% CI]: 4,207 [1,340-13,212]). Only depression significantly affects the GPA ofmedical students during the COVID-19 pandemic.

Recalcitrant Incomplete Secukinumab Administration in a Psoriasis Patient Gani Panjaitan, Joice Sonya; Suhartomi, Suhartomi
Journal of Biomedicine and Translational Research Vol 9, No 3 (2023): December 2023
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v9i3.19100

Background: Psoriasis is an immunologic-mediated disease affected by genetic factors that may affect the skin, joints, and cardiovascular system. Some biological agents have been developed and approved by FDA to treat psoriasis. One of these biological agents is Secukinumab, a fully human IgG1κ anti-interleukin-17A(IL-17A) monoclonal antibody. Case Presentation: A seventeen female teenager came to Dermatovenerology Clinic with scaly patches in the forehead and hairline around ten months ago with a history of repeat Corticoticosteroid, DMARDs, and biologic agent treatment. Dermatology examination showed erythema, induration, and desquamation in head and extremities with PASI score of 1.2. She was treated with initial and maintenance doses of Secukinumab Injection.Conclusion: It can be concluded that the recalcitrant administration of Secukinumab in Psoriasis patients may decrease the treatment response.

Analysis of factors influencing smoker behavior in designated non-smoking zone on campus Leonardi, Felix; Trirasetya, Mutiara Ulfa; Suhartomi, Suhartomi; Sihotang, Widya Yanti; Edison, Rizki Edmi
MEDIA ILMU KESEHATAN Vol 13 No 2 (2024): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v13i2.1365

Background: The GATS research findings indicate that tobacco use in Indonesia is the highest worldwide among teenagers, with a percentage of 34.8% consumed by individuals aged 15 and above. Tobacco companies leverage this legality to market cigarettes widely to students, including university students. Smoke-free areas are government efforts to prevent smoking on campuses.Objective: To identify determinant factors affecting non-smoking behavior among smokers in smoke-free campus areas.Methods: This research study is descriptive quantitative with a cross-sectional design. It used a purposive sampling technique with criteria of 74 male smoker students from the Faculty of Medicine and Dentistry at Universitas Prima Indonesia and was analyzed using a chi-square test.Results: The chi-square test analysis results indicated an effect between knowledge and attitude on non-smoking behavior in smoke-free campus areas with a P-value of 0.001.Conclusion: The research findings found that knowledge and attitude are determinant factors of non-smoking behavior among smokers in smoke-free campus areas.

Nephroprotective Effects of Sunkist Peel Ethanol Extract on Diabetic Nephropathy Mutia, Maya Sari; Ginting, Chrismis Novalinda; Yulizal, OK; Suhartomi, Suhartomi; Sihotang, Widya Yanti
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3496

The most common long-term diabetic complication is diabetic nephropathy which, in most cases, falls into the End-Stage Kidney Disease. Numerous studies on the nephroprotective effects of citrus fruit have been conducted recently. This study was performed to investigate the phytochemical properties of Sunkist peel ethanol extract and their possible effects on improving diabetic nephropathy. To get the extract, the Sunkist peels were macerated and the extract was analyzed by GC-MS. An in vivo assay of five different groups of 25 male Wistar rats was then performed using the extracts. The groups included control, standard, 500 mg/kg extract, 750 mg/kg extract, and 1,500 mg/kg BW extract. All rats were sacrificed after 28 days of treatment and VEGF level serum and kidney histology analysis were performed. The VEGF data were first analyzed descriptively, followed by one-way ANOVA or Kruskal-Wallis test based on the data distribution. Meanwhile, the kidney histology was observed and narratively described. Results showed that the Sunkist peel ethanol extract has a potential effect to suppress the VEGF level (p-value < 0.05). The extract at the highest dose revealed the mildest pathology damage in the form of tubular structure degeneration without any glomerular damage. This study indicates that Sunkist peel extract has nephroprotective effects from its various phytochemical compounds that work as antioxidants and anti-inflammation.

DETEKSI BAKTERI ENTEROBACTERIACEAE PADA AIR MINUM ISI ULANG YANG DIPRODUKSI OLEH DEPOT ISI ULANG DI SEKITAR MEDAN PETISAH Ginting, Audi Torry; Suhartomi, Suhartomi; Wardhani, Fiska Maya; Amelia, Sri; Sembiring, Mediana Br.
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 3 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i3.37479

Air merupakan kebutuhan utama bagi manusia. Kehidupan manusia tidak bisa terlepas dari air, terutama kebutuhan akan air minum. Pentingnya peran air dalam kebutuhan sehari-hari mendorong peneliti untuk mendeteksi keberadaan bakteri family Enterobacteriaceae yang berpotensi menyebabkan berbagai penyakit saluran cerna pada air minum yang diproduksi oleh depot isi ulang di Kecamatan Medan Petisah. Penelitian ini menganalisa 10 sampel air minum isi ulang dari beberapa depot air minum di kawasan Kecamatan Medan Petisah melalui Total Sampling Tecnique. Untuk isolasi dan identifikasi bakteri menggunakan media MacConkey Agar (MAC) dan Eosin Mehylen Blue (EMB), serta dilakukan berbagai reaksi biokimia. Hasil penelitian menunjukkan bahwa 8 dari 10 depot air minum terkontaminasi bakteri family Enterobacteriaceae dengan tingkat kontaminasi berkisar antara 2.00 x 101 sampai dengan 5.20 x 103 CFU/ml, nilai ini tidak melebih nilai ambang yang telah ditetapkan SNI tahun 2006. Isolat bakteri yang dijumpai dalam penelitian ini adalah Klebsiella sp.,dan Eschericia coli, kedua bakteri ini merupakan lactose fermenter Enterobacteriaceae, berdasarkan kemampuannya memfermentasi gula-gula menjadi senyawa yang bersifat asam. Oleh karena itu dapat disimpulkan bahwa mayoritas air minum isi ulang pada depot air minum di Kecamatan Medan Petisah terkontaminasi Enterobacteriaceae dalam jumlah yang rendah, sehingga memerlukan pemantauan lebih ketat demi menjamin kesehatan masyarakat

HUBUNGAN ANTARA GAMBARAN RUAM DENGAN HASIL PEMERIKSAAN KOH PADA PEMULUNG DI KOTA MEDAN Panjaitan, Joice Sonya Gani; Suhartomi, Suhartomi; Tarigan, Juliyanti
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 4 (2024)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i4.1314

Latar Belakang: Pemeriksaan KOH dari kerokan kulit dapat menunjukkan gambaran mikrobiologis yang beragam. Pemulung yang bekerja di Tempat Pembuangan Akhir (TPA) berisiko tinggi mengalami penyakit kulit, termasuk tinea pedis. Jadi, penting untuk memahami hubungan antara gambaran klinis ruam kulit dengan hasil pemeriksaan KOH pada populasi ini. Tujuan: untuk mengetahui hubungan antara gambaran ruam kulit dengan hasil pemeriksaan KOH kerokan kulit pada pemulung di TPA Kota Medan. Metode: Penelitian ini merupakan penelitian cross sectional terhadap 79 orang pemulung di Kota Medan yang dipilih secara purposive sampling. Pemeriksaan KOH dilakukan untuk mendeteksi adanya infeksi jamur, sementara gambaran klinis ruam kulit dianalisis untuk mengetahui faktor-faktor yang mempengaruhi kejadian tinea pedis. Hasil: gambaran klinis makula (nilai P= 0.014) dan squama (nilai P= 0.006) secara signifikan mempengaruhi kejadian tinea pedis pada pemulung di Kota Medan. Gambaran klinis makula memiliki nilai spesifisitas 80.95% yang lebih tinggi dibandingkan dengan nilai sensitivitas 50.00%. Sementara itu, gambaran klinis squama memiliki nilai sensitivitas yang lebih tinggi (51.72%) dibandingkan dengan nilai spesifisitas 14.29%. Kesimpulan: Gambaran klinis makula dan squama dapat saling melengkapi dalam menapis (screening) kejadian tinea pedis saat pemeriksaan fisik. Dengan demikian, pemeriksaan fisik yang mencakup identifikasi makula dan squama dapat meningkatkan akurasi diagnosa tinea pedis sebelum dilakukan pemeriksaan penunjang

Analysis of factors influencing smoker behavior in designated non-smoking zone on campus Leonardi, Felix; Trirasetya, Mutiara Ulfa; Suhartomi, Suhartomi; Sihotang, Widya Yanti; Edison, Rizki Edmi
MEDIA ILMU KESEHATAN Vol 13 No 2 (2024): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v13i2.1365

Background: The GATS research findings indicate that tobacco use in Indonesia is the highest worldwide among teenagers, with a percentage of 34.8% consumed by individuals aged 15 and above. Tobacco companies leverage this legality to market cigarettes widely to students, including university students. Smoke-free areas are government efforts to prevent smoking on campuses.Objective: To identify determinant factors affecting non-smoking behavior among smokers in smoke-free campus areas.Methods: This research study is descriptive quantitative with a cross-sectional design. It used a purposive sampling technique with criteria of 74 male smoker students from the Faculty of Medicine and Dentistry at Universitas Prima Indonesia and was analyzed using a chi-square test.Results: The chi-square test analysis results indicated an effect between knowledge and attitude on non-smoking behavior in smoke-free campus areas with a P-value of 0.001.Conclusion: The research findings found that knowledge and attitude are determinant factors of non-smoking behavior among smokers in smoke-free campus areas.

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