Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA)
Linda Chiuman
Prima Indonesia University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Physics

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Antidiabetic Activity of Cep-Cepan Leaf Extract Nanoparticles (Castanopsis costata) in Streptozotocin-Induced White Rat Models Astriani Natalia Br Ginting; Chrismis Novalinda Ginting; Gusbakti Rusip; Linda Chiuman
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.9408

Abstract

The cep-cepan plant (Castanopsis costata) from the Fagaceae family is traditionally used by the Karo community in Medan, North Sumatra, to treat diabetes mellitus, although its efficacy has not yet been scientifically proven. This study aimed to evaluate the effectiveness of the antidiabetic activity of cep-cepan leaf extract nanoparticles (Castanopsis costata) in a streptozotocin-induced white rat model. A total of 25 male white rats were divided into five treatment groups: a positive control group, a negative control group, and three experimental groups treated with extract concentrations of 25, 75, and 150 mg/kg body weight, respectively. Plasma glucose levels were measured every 72 hours for 15 days using blood samples taken from the tail. Pancreatic tissue was then examined, and the data were analyzed using one way anova. The findings showed significant antidiabetic activity in all treatment groups, with p < 0.001. The nanoparticle extract of cep-cepan leaves exhibited the highest antidiabetic potential at a dosage of 150 mg/kg, reducing blood glucose levels by 59.39%. These results suggest that the nanoparticle extract of cep-cepan leaves demonstrates antidiabetic activity in the streptozotocin-induced white rat model, and it has the potential to be developed as an alternative treatment for diabetes mellitus.
Anti-inflammatory Activity of Lemon Pepper Nanoemulsion on Carrageenan-Induced Male Wistar Rat Linda Chiuman; Dwi Putri Agita Sebayang; Veranyca Chiuman; Suhartomi Suhartomi
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6292

Abstract

Lemon pepper does not only have a unique taste but also has some active compounds, which has anti-inflammatory activity. This study intended to investigate the anti-inflammatory effect of lemon pepper nanoemulsion on carrageenan-induced Wistar rats. This experimental study used Twenty-five male Wistar rats that were grouped into five different groups, including control, standard, lemon pepper nanoemulsion dose of 25, 50, and 75 mg/ kgBW. Initially, all rats received air injection in the back area for 5 days to form an air pouch. After that, all rats were injected with 1% carrageenan solution, and received treatment based on the groups for 48 hours via oral route. Then, it counted the number of white blood cells by Giemsa Stain that was expressed as a number of cells per High Power Field (HPF). The increasing of Lemon pepper nanoemulsion dose significantly decreased the number of leucocytes in the carrageenan aspiration after 48 hours of treatment (P-Value < 0.001). The lowest number of leucocytes was found in the Lemon Pepper Nanoemulsion dose of 75 mg/kgBW (2.40 leukocytes per HPF). Hence, it can be deducted that the lemon pepper nanoemulsion has an anti-inflammatory effect, especially at a dose of 50-75 mg/kgBW.
Co-Authors Astriani Natalia Br Ginting Chrismis Novalinda Ginting Dwi Putri Agita Sebayang Gusbakti Rusip Suhartomi Veranyca Chiuman