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All Journal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Galenika
Asmiyenti Djaliasrin Djalil
Fakultas Farmasi Universitas Muhammadiyah Purwokerto
Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Formulasi Krim Antibakteri Ekstrak Teripang Pasir (Holothuria scabra Jaeger) Asmiyenti Djaliasrin Djalil; Adhika Rifki Ivani; Erza Genatrika
JURNAL FARMASI GALENIKA Vol 4 No 3 (2017): Jurnal Farmasi Galenika Volume 4 No. 3, 2017
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penelitian ini bertujuan untuk membuat formulasi dan mengevaluasi krim antiacne yang mengandung ekstrak metanol teripang pasir (Holothuria scabra Jaeger, 1833). Aktivitas antiacne ekstrak dan krim pada berbagai konsentrasi ekstrak diteliti terhadap bakteri Staphylococcus aureus dan Propionibacterium acnes menggunakan metode difusi agar dengan kertas cakram. Krim antiacne disiapkan dengan mencampurkan bahan-bahan dengan jumlah tertentu dengan ekstrak pada berbagai konsentrasi (0,05%; 0,1%; 0,2%). Krim yang dibuat dievaluasi sifat fisik dan reologi. Selanjutnya efikasi krim antiacne dibandingkan dengan produk komersial. Hasil penelitian menunjukkan bahwa ekstrak memiliki aktivitas antiacne yang baik, aktivitas semakin meningkat dengan meningkatnya konsentrasi ekstrak. Aktifitas antiacne tetap dimiliki pada saat ekstrak dibuat krim. Semua formula krim menunjukkan viskositas, daya sebar, pH, dan daya lekat yang baik. Krim juga menunjukkan kestabilan yang baik selama 1 bulan penyimpanan. Krim yang mengandung ekstrak teripang pasir berpotensi untuk dikembangkan sebagai krim antiacne untuk infeksi kulit yang disebabkan oleh Staphylococcus aureus and Propionibacterium acnes.
A Review: Photodynamic Therapy on Wound Healing Hasnita Hasnita; Hariyanti Hariyanti; Asmiyenti Djaliasrin Djalil
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 02 Desember 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v21i2.24377

Abstract

Background: Wound infection poses a significant challenge in wound healing, so overcoming microbial infections and accelerating wounds can be done using PDT (Photodynamic Therapy).  PDT is a non-invasive therapeutic method, light-based therapeutic method that can treat several pathological conditions such as wound healing, antimicrobial, antibiotic resistance bacteria, cancer, and skin repair. Objective: The review article aims to evaluate the effectiveness of PDT in accelerating wound healing. Methods: All articles in this review were taken from the Pubmed and Google Scholar internet databases from 2019 to 2024. Results: Twelve photosensitizers were explored for wound healing using PDT. Some were used in singular form, while others were used in combination. PDT promotes wound healing by killing bacterial cells and stimulating fibroblast proliferation, producing collagen and elastin. The mechanism for faster wound healing was detected by increasing the epithelialization process, decreasing angiogenesis, reducing the number of fibroblast cells, and raising collagen density. Conclusion: Based on research, PDT uses a specific photosensitizer that is activated by light to produce Reactive Oxygen Species (ROS) so that in wound healing, PDT stimulates the wound healing process by improving the quality of tissue formed, fast wound closure, reducing the risk of complications, increasing blood circulation, reduces inflammation and promotes the proliferation of cells involved in tissue regeneration.
Co-Authors Adhika Rifki Ivani Erza Genatrika Hariyanti Hariyanti Hasnita Hasnita