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All Journal Indonesia Journal of Halal JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Mattawang: Jurnal Pengabdian Masyarakat Archives of The Medicine and Case Reports Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Kefarmasian Indonesia Pharmacon: Jurnal Farmasi Indonesia
Pri Iswati Utami
Fakultas Farmasi, Universitas Muhammadiyah Purwokerto
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Analisis Asam Lemak Daging Anjing pada Bakso Sapi Menggunakan Gas Chromatography Mass Spectrometry (GCMS) yang Dikombinasikan dengan PCA (Principal Component Analysis) Irfan Nugraha; Pri Iswati Utami; Wiranti Sri Rahayu
Indonesia Journal of Halal Vol 1 (2) 2018
Publisher : Pusat Kajian Halal Undip

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.979 KB) | DOI: 10.14710/halal.v1i2.3668

Abstract

 Tingginya perbedaan harga daging, membuat beberapa penjual yang tidak etis mengganti daging sapi dengan daging anjing secara sengaja untuk mendapatkan keuntungan ekonomis. Tujuan dilakukan penelitian ini adalah untuk mengetahui kemampuan GCMS yang dikombinasi dengan kemometrika PCA untuk analisis cepat dari asam lemak anjing pada bakso formulasi dan bakso sapi di pasaran. Metode penelitian ini adalah non eksperimental berupa identifikasi profil asam lemak daging anjing  pada bakso sapi formulasi dan bakso sapi di pasaran. Hasil penelitian yang didapat berupa profil kromatogram GCMS menunjukkan bahwa terdapat perbedaan komposisi asam lemak antara daging anjing dan sapi. Pada lemak daging anjing muncul beberapa asam lemak yang tidak dimiliki oleh lemak daging sapi diantaranya asam kaproat, asam siklopentanetridekanoat, asam arakhidonat, asam 7,10,13- eikosatrienoat, asam 9,12,15- oktadekatrienoat. Analisis kualitatif dari kromatogram GCMS menggunakan PCA menunjukkan lemak sapi, anjing, kambing, babi dan ayam dapat diidentifikasi dan dibedakan. Analisis kualitatif kandungan lemak anjing dalam bakso sapi formulasi menunjukkan perbedaan antara bakso formulasi yang memiliki kedekatan mirip dengan lemak sapi serta yang mirip dengan lemak anjing. Analisis kualitatif lemak anjing pada bakso sapi di pasaran menunjukkan sampel tidak mengandung lemak anjing.Kata kunci : bakso, GCMS, lemak daging anjingABSTRACTDue to the high difference of meat price, some unethical seller replaces beef intentionally with dog meat to get economical profits. The objective of this study is to assess the capability of GCMS coupled with chemometrics of PCA for rapid screening of dog fat in beef meatball formulation and beef meatballs in the market. The method of this research is non experimental that is identification of fatty acid profile of dog meat in beef meatball simulation and beef meatballs in the market. The result obtained from GCMS chromatogram profile showed that there is a difference in fatty acid composition between beef and dog meat. In dog meat fat appears some fatty acids that are not owned by beef fat i.e caproic acid, cyclopentanetridecanoic acid, arachidonate acid, 7,10,13-eicosatrienoic acid, 9,12,15-octadecatrienoic acid. Qualitative analysis from GCMS chromatogram using PCA showed that beef, dog, goat, pork and chicken can be identified and differentiated. Qualitative analysis of dog fat in simulated beef meatballs showed difference between simulated meatballs that have similar proximity to beef's fat as well as those that are similar to dog fat. Qualitative analysis of dog fat in beef meatballs in the market showed the sample doesn't contain dog fat. Keywords : dog meat fat, GCMS, meatball
ANALISIS NATRIUM NITRIT SECARA SPEKTROFOTOMETRI VISIBEL DALAM DAGING BURGER YANG BEREDAR DI SWALAYAN PURWOKERTO Pudji Lestari; Sabikis Sabikis; Pri Iswati Utami
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 08 No. 03 Desember 2011
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v8i03.1134

Abstract

ABSTRAK Metode spektrofotometri visibel dapat digunakan untuk menetapkan kadar natrium nitrit dalam daging burger. Metode ini didasarkan pada reaksi diazotasi antara asam nitrit (dari natrium nitrit dalam suasana asam) dengan amin aromatis primer (asam sulfanilat) membentuk garam diazonium. Selanjutnya direaksikan dengan naftiletilendiaminn membentuk senyawa berwarna dan diukur absorbansinya pada panjang gelombang 546,50 nm. Hasil penelitian menunjukkan kadar rata-rata natrium nitrit pada sampel daging burger merk A sebesar 76,65 mg/kg dan merk D sebesar 109,72 mg/kg. Hasil pengujian menunjukkan bahwa kadar natrium nitrit yang terdapat dalam masing-masing sampel tidak melebihi batas maksimum penggunaan natrium nitrit sesuai Permenkes No.722/Menkes/Per/IX/88 tentang bahan tambahan makanan yaitu 125 mg/kg sehingga masih aman untuk dikonsumsi. Hasil validasi metode analisis yang dilakukan diperoleh nilai koefisien korelasi 0,998; batas deteksi dan batas kuantitasi masing-masing 0,142 dan 0,473 ppm; nilai perolehan kembali rata-rata dan nilai kesalahan sistematik sebesar 88,13 % dan 11,87 % ; nilai standar deviasi, koefisien variasi dan ketelitian alat pada uji presisi alat masingmasing sebesar 0,016; 1,59 % dan 98,41 %. Kata kunci : Natrium nitrit, Daging burger, Validasi metode, Spektrofotometri Visibel. ABSTRACT Visible spectrophotometric method can be used to determine levels of sodium nitrite in meat burgers. This method is based on diazotation reaction between nitrite acid (from sodium nitrite in acid conditions) with primary aromatic amines (sulfanilic acid) to form diazonium salt. Subsequently reacted with naftiletilendiamin form colored compounds and absorbance was measured at a wavelength of 546.50 nm. The results showed average levels of sodium nitrite in meat samples burger brand A of 76.65 mg/kg and D brand of 109.72 mg/kg. Test results showed that the levels of sodium nitrite contained in each sample does not exceed the maximum limit the use of sodium nitrite according Permenkes No.722/Menkes/Per/IX/88 about food additive which is 125 mg / kg so it is still safe for consumption. The results of the analysis conducted method validation values obtained correlation coefficient 0.998; limit of detection (LOD) and limit of quantitation (LOQ) of each 0.142 ppm and 0.473 ppm; the average recovery and the value of systematic error of 88.13% and 11, 87%; value of standard deviation, coefficient of variation and correctness of appliance at precision test each of 0.016; 1.59% and 98.41%. Key words: Sodium nitrite, Meat burger, Method validation, Visible Spectrophotometry.
ANALISIS CEMARAN TEMBAGA DALAM AIR SUMUR INDUSTRI PELAPISAN EMAS DI KOTA TEGAL DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM Listiowati Listiowati; Wiranti Sri Rahayu; Pri Iswati Utami
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 08 No. 03 Desember 2011
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v8i03.1132

Abstract

ABSTRAK Telah dilakukan penelitian tentang analisis tembaga dalam air sumur. Tujuan dari penelitian ini untuk menetapkan kadar tembaga dalam air sumur. Analisis menggunakan metode spektrofotometri serapan atom (SSA) dengan destruksi basah. Panjang gelombang untuk pengukuran tembaga adalah 324,8 nm. Hasil analisis menunjukkan bahwa logam tembaga pada semua sampel tidak terdeteksi. Hasil validasi metode analisis yang telah dilakukan meliputi akurasi, presisi, dan linearitas (0,2–1,0 ppm) memenuhi persyaratan yang ditentukan. Persamaan regresi linear kurva baku y = 0,034 x–1,76 . 10 -3 dan r = 0,998. Kata Kunci: analisis tembaga, air sumur, spektrofotometri serapan atom (SSA). ABSTRACT It had been done research about analysis of copper in ground water. The purpose of this research was to determine levels of copper in ground water. Analysis using atomic absorption spectrophotometry (AAS) method with wet destruction. Measurement wavelength was 324.8 nm for copper. The analysis showed that the concentration of copper metal was not detected in all samples. The results of the validation method of analysis has been conducted include accuracy, precision, and linearity (0.2 to 1.0 ppm) to meet the specified requirements. Standard curve linear regression equation y = 0.034x-1.76.10-3 and r = 0.998 Keywords: analysis of copper, ground water, atomic absorption spectrophotometry (AAS).
The Effect of Lifestyle, Spiritual, and Family Support on Diabetic Mellitus Patient with Chronic Kidney Disease Complication Anwar Rosyadi; Indri Hapsari; Pri Iswati Utami
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 02 Desember 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i2.13255

Abstract

Patients with Diabetes Mellitus (DM) with complications of chronic kidney disease (CKD) have decreased quality of life (QOL). Some factors that can affect QOL are lifestyle, spirituality, and family support. The purpose of this study was to determine the effect of lifestyle, spirituality, and family support on the QOL of DM patients with CKD complications at Siaga Medika Purbalingga Hospital. Respondents from this study were all patients diagnosed with DM with CKD complications and had a history of treatment in August 2019-September 2020 period. A total of 48 respondents then filled out a questionnaire that had been tested for validity and reliability. The results of this study are respondents have a good quality of life as much as 62.5%, and the remaining 32.5% are not good. Patients who have a better lifestyle and spiritual level have 11 times the chance of having a better QOL. Meanwhile, patients who have better family support have a 0.13 times better chance of their QOL. In conclusion, there is a significant impact between lifestyle, spirituality, and family support with QOL. Hospitals are urgently needed in providing counseling about the importance of lifestyle, spirituality level and family support so that the patient's QOL increases.
Comparative Effectiveness of Single Versus Combination Antihypertensive Therapy in PROLANIS Hypertension Patients: A Retrospective Study in Purbalingga Regency Khamdiyah Indah Kurniasih; Nanang Munif Yasin; Utami, Pri Iswati
Archives of The Medicine and Case Reports Vol. 5 No. 4 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i4.625

Abstract

The PROLANIS program in Indonesia aims to manage chronic diseases like hypertension. While combination antihypertensive therapy is recommended for many patients, evidence on its effectiveness in the PROLANIS setting remains limited. This study investigated the comparative effectiveness of single versus combination antihypertensive therapy in achieving blood pressure control among PROLANIS hypertension patients in Purbalingga Regency. A retrospective cohort study was conducted using data from PROLANIS hypertension patients in Purbalingga Regency from January-December 2023. Patients were categorized into two groups: those receiving single antihypertensive therapy and those receiving combination therapy. The primary outcome was the proportion of patients achieving blood pressure control (<140/90 mmHg). Secondary outcomes included changes in blood pressure, medication adherence, and adverse events. Multivariable logistic regression was used to adjust for potential confounders. A total of 1,250 patients were included, with 680 receiving single therapy and 570 receiving combination therapy. The proportion of patients achieving blood pressure control was significantly higher in the combination therapy group (65%) compared to the single therapy group (52%) (adjusted odds ratio [OR] 1.72, 95% confidence interval [CI] 1.35-2.20). Combination therapy was also associated with greater reductions in systolic and diastolic blood pressure. No significant differences were observed in medication adherence or adverse events between the two groups. Combination antihypertensive therapy is more effective than single therapy in achieving blood pressure control among PROLANIS hypertension patients in Purbalingga Regency. These findings support the use of combination therapy as the preferred approach for managing hypertension in this population.
Profil Distribusi Apotek di Kabupaten Banyumas berdasarkan Sistem Informasi Geografi dan Korelasinya dengan Jumlah Kunjungan dan Resep Tahun 2019 Manan, Abdul; Utami, Pri Iswati; Siswanto, Agus
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 2, AGUSTUS 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i2.3961

Abstract

The distribution of pharmacies in Indonesia is still becoming a problem. Pharmacies are mostly available around healthcare facilities such as hospitals, service providers, trade centers, transportation facilities, and main roads. The study aims to describe the distribution profile of pharmacies based on Geographic Information System (GIS) analysis and to study the relation between pharmacy distribution profiles with the number of consumer visits and prescriptions. The study is conducted in 27 sub-districts in Banyumas Regency, Central Java using Arc Gis 3.10.2 Software. Pharmacy profile, the number of consumer visits, and prescriptions at the pharmacy are obtained by distributing research questionnaires to pharmacists. The results showed that the distribution of pharmacies in the Banyumas Regency was still dominant in urban areas, which reached 55%. The average distance of pharmacies was 2.34 km. The research results on the distribution pattern of pharmacies in 27 sub-districts showed that in 3 districts (11.1%) were grouped in certain areas, in 24 other districts (88.9%), the pharmacies' distribution had a spread distribution pattern. The conclusion of the research that the distribution of pharmacies in the Banyumas Regency based on GIS visualization was still dominant in urban areas and especially in sub-districts around the capital of Banyumas Regency, Purwokerto. Based on the study, there was a relation between the average distance of pharmacies and the number of healthcare facilities on consumer visits. There was a relation between pharmacy density, population density, and the number of healthcare facilities with the number of prescriptions.
Formulasi dan Uji Sifat Fisik Sediaan Lulur Krim dari Ekstrak Etanol Daun Sirsak (Annona muricata L.) serta Penentuan Aktivitas Antioksidannya Hakim, Zainur Rahman; Meliana, Dewi; Utami, Pri Iswati
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.2.135-142.2020

Abstract

The ethanolic extract of soursop leaves (Annona muricata L.) is reported as an antioxidant agent with an IC50 value of 14.48 µg/mL. This research aimed to examine physical characteristics and investigate the antioxidant activity of the ethanolic extract of soursop leaves in a scrub cream. Soursop leaves powder was extracted with 70% ethanol and formulated as scrub cream at the concentration of 1.4%, 2.8%, and 4.2%, then evaluated for physical characteristics. The antioxidant activity was evaluated using DPPH (1.1-diphenyl-2 picrylhydrazyl) method. The result showed that the scrub cream at all concentrations tested fulfilled all physical characteristics required for good topical preparations. These included organoleptic, homogeneity, viscosity, pH, spreadability, and adhesion. The IC50 value of the scrub cream at the concentration of 1.4%, 2.8 %, and 4.2% were 30.72, 26.82, and 24.03 µg/mL, respectively. The IC50 values indicated that the scrub creams exhibit radical scavenging activities which categorized as strong activity antioxidants.
Narrative Review: Extraction and Characterization of Collagen from Various Fish Species Mufidah, Aidatul; Rahayu, Wiranti Sri; Utami, Pri Iswati
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.5391

Abstract

Collagen is a significant biomaterial in medical applications because of its unique properties, such as biodegradability and low antigenicity. As a result, collagen has been used in drug delivery systems and tissue engineering. Most commercial collagen is derived from cow skin, pig skin, or chicken waste. These terrestrial animal sources are inappropriate for many religious and ethnic groups, present regulatory and quality control challenges, and might contain contaminants and biological toxins, including BSE (mad cow disease). This review summarizes an overview of recent research conducted from 2014 to 2024 on collagen extraction from fish. Data were retrieved from online publications on the Pubmed database and covered fish collagen, extracts, and characterization. Fish by-products have been shown to be useful for producing collagen that can substitute porcine and bovine sources. Collagen extracted from fish body parts is classified as type 1. Some typical marine collagen characterization methods thats are often used are FTIR and SDSPAGE. Fish by-products have been proven to be valuable to produce collagen which can replace porcine and bovine sources. Fish by-products may be an alternative to the more prevalent collagen extraction methods.
Assistance in Implementing Hygiene and Sanitation to Promote Halal Certification at UMKM Pabrik Kerupuk in Linggasari Purwokerto Djalil, Asmiyenti Djaliasrin; Utami, Pri Iswati; Suparman; Utaminingrum, Wahyu; Rahayu, Wiranti Sri; Mulyani, Ayu; hasnita
Mattawang: Jurnal Pengabdian Masyarakat Vol. 5 No. 3 (2024)
Publisher : Yayasan Ahmar Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35877/454RI.mattawang2815

Abstract

Healthy and nutritious food is a basic human necessity. Therefore, it is crucial to ensure that our food is healthy, nutritious, and halal according to Islamic law. This community service activity aimed to support sanitation hygiene requirements for obtaining halal certification at the UMKM Pabrik Kerupuk in Linggasari, Kembaran, Purwokerto. The methods used included observation, interviews, training, and evaluation. The results revealed that while the factory had met several requirements, there were areas for improvement in the use of work clothes and gloves, vector control, and the provision of closed waste bins. The education provided raised awareness among owners and employees about the importance of maintaining product cleanliness and safety. By adhering to reasonable standards, the UMKM can enhance product quality, consumer confidence, and compliance with relevant regulations.
ANALISIS KORELASI NILAI SPF DAN KANDUNGAN SENYAWA POLIFENOL TOTAL EKSTRAK BUNGA ROSELLA (Hibiscuss sabdariffa L.) DAN TELANG (Clitoria ternatea L.) Fitri, Hidayah Anisa; Shafiyatun, Arina Nur Nida; Utami, Pri Iswati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2300

Abstract

Excessive and persistent sun exposure containin UV B radiation to the skin causes both acute and chronic sunburn. Polyphenol compounds contained in red rosella extract (ER1), purple rosella extract (ER2) and telang (ET) extracst have photoprotective activity toward UV including UV B. This study aimed to determine their SPF value, total phenolic content (TPC) and their total flavonoids content (TFC) in vitro and to analyze the correlation between the three parameters. In vitro test was performed by UV-Vis spectrophotometry method and correlation was analyzed statistically using two-tailed pearson, graphic plotting and r-value analysis. Results showed that in 0,8% concentration, ER1 and ER2 having maximum SPF values, while ET having ultra SPF value. There was a very strong relationship between SPF, TPC and TFC in the extracts and all of them dependent in concentration. The higher concentration of extract used, the higher the number of TPC, TFC and SPF value. The photoprotective mechanism towards UV B light of ER1 and ER2 were likely contributed by their TPC, but it was both TPC and TFC for ET.
Co-Authors Abdul Manan Agus Siswanto Angga Tiya Warma Sarigih Ani Puji Lestari Anjar Mahardian Kusuma Anwar Rosyadi Asih Mahmudah Sanusi Asmiyenti Djaliasrin Djalil Binar Asrining Dhiani Dewi Andriyani Didik Setiawan Dwi Hartanti Eka Prasetyo Agung Pambudi Fajrin Noviyanto, Fajrin Febriyanti Diah Puspita Sari, Febriyanti Diah Puspita Fendi Nugroho Fitri, Hidayah Anisa Hakim, Zainur Rahman Hasnita Ika Yuniastuti Indah Puji Lestari Indri Hapsari Irfan Nugraha Khamdiyah Indah Kurniasih Listiowati Listiowati Meliana, Dewi Muchammad Ade Firmansyah, Muchammad Ade Mufidah, Aidatul Mufti Kharismawati Muhammad Irfan Firdaus Mulyani, Ayu Nanang Munif Yasin Nur Aida Masyitoh Nur Ida Dwi Retnani Pudji Lestari Retno Wahyuningrum Rizki Widyaningsih Roselina Wulandari Sabikis Sabikis Sabikis Sabikis, Sabikis Shafiyatun, Arina Nur Nida Siti Helmyati Sochib Ibnu Fajar Suparman Tjiptasurasa Tjiptasurasa, Tjiptasurasa Wahyu Utaminingrum Wiranti Sri Rahayu Wiranti Sri Rahayu