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All Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Farmasi Indonesia
Dion Notario
Department of Pharmacy, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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A Validated RP-HPLC-PDA with Buffer-Free Gradient Elution for Simultaneous Plasma Analysis of Trimethoprim and Sulfamethoxazole Nicholas Edmund; Untung Gunawan; Dion Notario
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.498

Abstract

A simple, cost-effective, and validated reversed-phase high-performance liquid chromatography (RP-HPLC) method is crucial for accurately monitoring trimethoprim and sulfamethoxazole therapy. However, conventional HPLC methods often rely on buffered mobile phases and additives, which can lead to column blockage and shorten column lifespan. To address this issue, we developed and validated a reversed-phase HPLC method with a photodiode array (PDA) detector, using a buffer-free and additive-free mobile phase with gradient elution. Sample preparation was performed using organic solvent-based deproteinization to minimize matrix effects. Chromatographic separation was performed on a ZORBAX Eclipse Plus C18 column (250 × 4.6 mm, 5 µm) using a mobile phase of acetic acid (pH 2.3), methanol, and acetonitrile at a flow rate of 1 mL/min. Detection was carried out at 270 nm with a total run time of 17 minutes. The analytical method exhibited linearity, precision, and accuracy, with adequate sensitivity for the analytes of interest. Stability testing yielded favorable results under various storage conditions, including the autosampler, freeze-thaw cycles, and long-term storage. However, the trimethoprim stock solution was only stable for two days and must be freshly prepared. Full validation was conducted in accordance with FDA and ICH bioanalytical guidelines, confirming its suitability for clinical application.
Kepuasan Pasien pada Telefarmasi vs Farmasi Konvensional: Analisis SERVQUAL Lusy Noviani; Dion Notario; Wanda Aurina
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.572

Abstract

Telepharmacy offers a promising solution to overcome the geographical limitations of traditional pharmacies. However, concerns regarding the quality of services delivered through telepharmacy highlight the need for a comprehensive evaluation of patient satisfaction. This study aimed to compare patient satisfaction between telepharmacy and conventional pharmacy services and to identify areas for improvement. A cross-sectional study was conducted in March and April 2024, involving a sample of 136 customers from the Atma Jaya Teaching Pharmacy in North Jakarta. Patient satisfaction was measured using a validated questionnaire, and key satisfaction dimensions were identified through Importance-Performance Analysis (IPA). The analysis revealed that both telepharmacy and conventional pharmacy services demonstrated strengths in the dimensions of Assurance and Responsiveness, which are critical to customer satisfaction (quadrant II : keep up the good work). Meanwhile, Reliability and Empathy were perceived as less important in both service models (quadrant III : low priority). The Tangible dimension, however, was identified as an area requiring improvement (quadrant I : concentrate here). These findings suggest that telepharmacy can provide patient satisfaction comparable to conventional pharmacies, particularly in the dimensions of Assurance and Responsiveness. However, the Tangible dimension remains a key area for improvement.
Heparin Vs Enoxaparin: Effects On D-Dimer And Hospital Stay In Covid-19 Patients Fonny Cokro; Novita Suryamin; Dion Notario; Agnes Anania Triavika Sahamastuti; Catherine Keiko Gunawan; Anton Sumarpo
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 3 (2026): Volume 13 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i3.23094

Abstract

Elevated d-dimer levels due to venous thromboembolism and hypercoagulability in covid-19 patients play a role in disease severity and poor clinical outcomes. This study aims to compare the effectiveness of heparin and enoxaparin, two recommended anticoagulants, in reducing d-dimer levels and hospital stay duration in hospitalized covid-19 patients. This retrospective cohort study involved 106 hospitalized covid-19 patients with abnormal d-dimer levels treated between March 2020 and March 2023. The assessment included changes in d-dimer levels and hospitalization duration. Statistical analyses were performed using stata software. Patients receiving enoxaparin were 5.913 times more likely to experience a reduction in d-dimer levels compared to those receiving heparin (p=0.021). While smoking status (or=0.034; p=0.001) and the number of comorbidities (or=11.247; p=0.018) were notable factors influencing d-dimer reduction, enoxaparin administration was linked to significantly longer hospitalization (p=0.024). The severity of covid-19 also had a substantial impact on hospital stays, with severe (β = 5.757; p= 0.004) and critical (β = 9.147; p 0.001) cases requiring extended care. Thus, enoxaparin demonstrates greater efficacy in reducing d-dimer levels in hospitalized covid-19 patients, though at the cost of prolonged hospital stays. 
Co-Authors Agnes Anania Triavika Sahamastuti Anton Sumarpo Catherine Keiko Gunawan Cokro, Fonny Gunawan, Untung Lusy Noviani Nicholas Edmund Novita Suryamin Wanda Aurina