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All Journal Buletin Veteriner Udayana Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research)
Zainal Abidin Kholilullah
Program Studi Kedokteran Hewan Fakultas Kedokteran Universitas Hasanddin, Jl. Perintis Kemerdekaan Kampus Tamalanrea Km. 10 Makassar, Indonesia 90245
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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The Effect of Garlic Extract on the Average Number of Lecocytes in Mice Infected with T. Evansi Zainal Abidin Kholilullah; Adryani Ris; Nurul Istiana; Muhammad Multazam; Mus Hilda Yuliani
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) VOLUME 6 No.1, JANUARY 2022
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jrvi.v6i1.15008

Abstract

Trypanosomiasis is one of the most widespread diseases in the world. This disease is an infectious disease that often occurs in various types of livestock, especially horses, buffalo and cattle. Trypanosomiasis can cause weakness in infected animals, which can end in death in these animals. This disease is caused by infection with the blood parasite Trypanosoma evansi (T. evansi). The activity of this parasite is very fast. Shortly after entering the animal's body, T. evansi immediately enters the circulatory system and performs breeding activities that can cause damage to blood cells (Ressang, 1984; Wayan et.al 2013). Treatment of trypanosomiasis is currently still using commercial synthetic drugs which are quite expensive, and it has even been found that some substances are no longer effectively used to kill T. evansi. Treatment using basic ingredients derived from plants can be an alternative that needs attention. Garlic bulbs are known to have potential as anti-microbial agents. Its ability to inhibit microbial growth is very broad, including viruses, bacteria, protozoa, and fungi (Nok et al., 1996; Zhang, 1999; Pizorno and Murray, 2000; Yin et al., 2002). Garlic (Allium sativum L) has been widely studied and the results are known to contain active compounds including flavonoids and allicin which have antibacterial, anti-parasitic and antiviral effects (Londhe, 2011). The aim of this study was to determine the effect of giving garlic extract on the average number of white blood cells of mice infected with T. evansi. The study was conducted on thirty male mice of the DDY strain with a body weight of 25-30 g per head which were divided into six treatment groups. Each treatment used five mice as replicates, namely: the untreated group, as a normal control (K0); the group infected with T. evansi intraperitoneally at a dose of 103/0.3 mL; divided into several groups, namely those who were not given any treatment (K1, negative control), the group that was given trypanocidal (K2, positive control), the group that was given garlic extract at a dose of 50 mg/kgBW (K3); the group given garlic extract at a dose of 100 mg/kgBW (K4) and the group given garlic extract at a dose of 200 mg/kgBW (K5). In this study, it was shown that at the beginning of T. evansi infection it caused an increase in the average number of leukocytes in the group of mice that did not receive treatment (K1) and those given trypanocidal (K2), while the group of mice that received treatment with garlic extract showed a decrease in the number the mean leukocyte count (K3 and K4) or a non-significant increase in the mean leukocyte count (P<0.05) at K5.
Pengaruh Pemberian Ekstrak Bawang Putih Terhadap Gambaran Jumlah Rata-Rata Eritrosit Mencit yang Diinfeksikan Trypanosoma evansi Adryani Ris; Zainal Abidin Kholilullah; Jasti Rahayu; Rasdiyanah Rasdiyanah; Risha Catra Pradhany; Ikhwan Yuniarto
Buletin Veteriner Udayana Vol. 14 No. 5 October 2022
Publisher : The Faculty of Veterinary Medicine, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2022.v14.i05.p20

Abstract

The aim of this study was to determine the effect of garlic extract administration on the profile of erythrocytes average number in mice infected with Trypanosoma evansi. T. evansi was isolated from surra cases in Buntok, South Kalimantan in 2019, and garlic was extracted by maceration method. The samples of this research used 30 male mice from the Deutch Democratic Yokohama strain with 25-30 grams body weight and grouped into 6 treatments. Each treatment consisted of 5 mice, 4 groups of it which were infected with T. evansi injected by intraperitoneal route. The results of the erythrocyte's average number showed the group of mice without treatment (K0) was 8.92±0.41 x106/?l at the beginning and 8.31±0.63 x106/?l at the end of the study. In the group of mice infected with T. evansi without treatment (K1) the average number of erythrocytes before infection was 8.20±1.01 x106/?l and 6.35±3.91 x106/?l after infection. The average number of erythrocytes in the group of mice infected with T. evansi and administered trypanosidal (K2) before infection was 8.44±1.27 x106/?l and 7.02±2.78 x106/?l after infected. The treatment of the mice group with garlic extract doses, 50 mg/kg BW (K3), 100 mg/kg BW (K4), 200 mg/kg BW (K5), before infected with T. evansi, the erythrocytes average number was 7.92±0.54 x106/?l, 7.88±0.09 x106/?l, 8.41±0.93 x106/?l, and 7.34±4.35 x106/?l, 5.85±1.53 x106/?l, 6.79±1.18 x106/?l after infected. Based on the results, concluded that there was no significant difference in the administration of garlic extract with the profile of erythrocytes average number in mice infected with T. evansi. Therefore, it is necessary to conduct further studies and research on other parameters such as the form of cell morphometric measurements and the average number of other cells such as leukocytes and platelets.
The Potential of House Geckos in the Spread of Salmonellosis in Makassar City Yusuf, Baso; Kholilullah, Zainal Abidin; Suharto, Rian Hari; Rell, Fedri; Jamaluddin, Abdul Wahid; Mapparenta, Bulan Allu; Syahbar, Lutfiah Kurnia; Aprilia, Eka; Alamsyah, Muhammad
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) VOLUME 8 No. 2, JULY 2024
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jrvi.v8i2.42040

Abstract

Salmonellosis is a significant global public health concern caused by the bacterium Salmonella spp. As a zoonotic disease, it can be transmitted between animals and humans, leading to various clinical symptoms in humans, including gastroenteritis, diarrhea, vomiting, enteric fever, and septicemia. This study examines the presence of Salmonella spp. in house geckos (Hemidactylus frenatus and Cosymbotus platyurus), which may act as zoonotic reservoirs. A total of 50 house geckos were collected from residential areas across five districts in Makassar City—Biringkanaya, Tamalanrea, Tallo, Manggala, and Rappocini—from March to September 2024. Skin, oral, and fecal samples from the geckos were cultured on nutrient agar, brain heart infusion broth, and selective Salmonella-Shigella agar, with bacterial identification confirmed using MALDI-TOF mass spectrometry. Findings revealed the presence of Salmonella enterica ssp. enterica in geckos from the Manggala district, highlighting a potential pathway for environmental contamination and zoonotic disease transmission. This study underscores the need for public awareness regarding the health risks associated with household reptiles and emphasizes preventive sanitation measures to reduce potential pathogen exposure. These findings serve as a foundation for future research on zoonotic reservoirs in urban environments.
Used of Turmeric in Handling Myiasis in Bali Cattle in North Sinjai District, South Sulawesi Rell, Fedri; Jamilah, Ainun; Ris, Adryani; Purba, Fika Yuliza; Jamaluddin, Abdul Wahid; Apada, Andi Magfira Satya; Yusuf, Baso; Suharto, Rian Hari; Kholilullah, Zainal Abidin; Rasdiyanah
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) VOLUME 9, No 1, JANUARY 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jrvi.v9i1.42122

Abstract

Myasis is a disease that commonly occurs in ruminants with the incidence of myasis increasing from year to year in Indonesia, especially in rural areas, with an incidence rate of 70% and a recurrence rate of up to 40% in cattle, buffalo, horses and goats. This disease is characterized by the presence of wounds and maggots. The presence of secondary infections will make the disease worse. Therefore, it is necessary to handle miasis cases so that they do not cause losses to farmers. A 7 year old of bali cattle in the North Sinjai district experienced miasis on the head. Treatment for myasis includes washing the wound, removing maggots and administering medication. Treatment uses the antibiotic oxytetracycline, anti-inflammatories, and vitamins as well as turmeric powder as a topical treatment. With the handling and treatment given, the cow showed recovery within 2 weeks. There is a need to improve election management so that this miasis incident does not happen again. As well as the need for socialization from related departments regarding livestock diseases and livestock rearing management.
Co-Authors Abdul Wahid Jamaluddin Adryani Ris Adryani Ris Adryani Ris Apada, Andi Magfira Satya Aprilia, Eka Baso Yusuf Fedri Rell Ikhwan Yuniarto Jamilah, Ainun Jasti Rahayu Mapparenta, Bulan Allu Muhammad Alamsyah Muhammad Multazam Mus Hilda Yuliani Nurul Istiana Purba, Fika Yuliza Rasdiyanah Rasdiyanah . Risha Catra Pradhany Suharto, Rian Hari Syahbar, Lutfiah Kurnia