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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal Majalah Farmasetika
Aristokrat, Aria
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Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Medicine & Pharmacology Public Health Other

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In Silico Evaluation: Bioactive Compounds in Soursop Plant (Annona muricata L.) as Caspase-3 Inhibitor for Prostate Cancer Aristokrat, Aria; Widati Aqila Rumawan, Maritsa; Amalia Hanifa, Zahra; Luthfiyah Rahmani, Syifa; Hanifah; Parameswari, Natashya; Puteri Agustina Pribadi, Alya; Lia Aulifa, Diah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.1-11

Abstract

Background: Prostate cancer has become one of the leading causes of death in men. Cancer patients often seek alternative treatments apart from chemotherapy, radiation therapy, and surgery. The use of medicinal plants in both preventive and curative actions in healthcare has been widely recognized. One of the plants known to have anticancer activity is the soursop leaf (Annona muricata L.). Objective: This study was conducted to explore the potential of active compounds contained in A. muricata as drug candidates for the inhibition of caspase-3 in silico. Methods: The research began with the prediction of Lipinski's Rule of Five and ADMET properties for the compounds found in A. muricata. The prediction process was followed by pharmacophore modelling and molecular docking simulations on caspase-3 (PDB: 1NME) as the target protein and 2-hydroxy-5-(2-mercapto-ethylsulfamoyl)-benzoic acid as the natural ligand using AutoDockTools 1.5.6. Results: Based on the molecular docking results, 22 test ligands were able to form bonds with the caspase-3 enzyme. The two best interactions were observed with the test ligands, Isolaureline and S-norcorydine, with binding energy values of -6.20 kcal /mol and -6.12 kcal /mol and inhibition constant values of 28.65 µM and 32.53 µM. In terms of receptor-target interactions, these two compounds also exhibited hydrogen bonding and van der Waals interactions similar to the natural ligand. Conclusion: The best bioactive compounds in A. muricata (Isolaureline and S-norcorydine) were predicted to have the ability to interact with caspase-3 and the potential to be used as prostate cancer drug candidates.
Anti-thrombocytopenic Activities of 15 Selected Indonesian Medicinal Plants: Psidium guajava Leaves, Phyllanthus niruri Aerial Parts, and Andrographis paniculata Leaves as Potential Sources in Enhancing Platelet Levels in Rats Susilawati, Yasmiwar; Tjitraresmi, Ami; Sofian, Ferry Ferdiansyah; Halimah, Eli; Dewi, Humaira Praswatika; Aristokrat, Aria
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3575

Abstract

BACKGROUND: Thrombocytopenia is a medical condition characterized by a low platelet count in the blood, which can cause excessive bleeding and serious complications. Current conventional treatments for thrombocytopenia often present significant side effects and limitations, necessitating the exploration of alternative therapeutic options. Therefore, this study was conducted to evaluate the potential of Indonesian ethnomedicinal plants as alternative therapies.METHODS: The research was conducted by ethanol maceration of 15 medicinal plants selected based on their use in traditional Indonesian medicine to treat thrombocytopenia. Male white rats, aged three month and weighing between 150 and 250 g, were divided into four groups, which each group consists of five rats: the negative control group, group receiving 250 mg/kg BW extract, group receiving 500 mg/kg BW extract, and the normal control group. The effects of the test preparations on platelet count, erythrocyte count, and hematocrit were observed after 7 days of treatment.RESULTS: Among of 15 medicinal plants extract tested at a dose of 500 mg/kg BW, Psidium guajava L. leaves extract showed to increase blood platelets counts in thrombocytopenic mice by 60.82% (p<0.01) followed by Phyllanthus niruri L. aerial parts extract at (48.22%; p<0.01), and Andrographis paniculata (Burm.f.) Wall. ex Nees leaves extract (47.14%; p<0.01).CONCLUSION: The extracts of P. guajava leaves, aerial parts of P. niruri, and A. paniculata leaves exhibited significant potential in enhancing platelet levels. These findings suggest that some Indonesian medicinal plants can be used as alternative therapy for thrombocytopenia.KEYWORDS: dengue hemorrhagic fever, Phyllanthus niruri, Psidium guajava, Andrographis paniculata, thrombocytopenia
Kajian Risiko Validasi Pembersihan Mesin yang Dilakukan Secara Manual Dengan Metode Failure Mode and Effects Analysis Aristokrat, Aria; Chaerunisaa, Anis Yohana
Majalah Farmasetika Vol 10, No 6 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v10i6.67440

Abstract

 Kontaminasi silang pada sarana produksi adalah hal yang sangat dihindari sehingga perlu dilakukannya pembersihan yang sudah divalidasi karena residu yang tersisa dapat menjadi cemaran. Namun, terdapat risiko yang dapat terjadi selama dilakukannya validasi pembersihan. Oleh karena itu penting untuk mengkaji risiko tersebut. Penelitian ini akan mengkaji resiko yang dapat terjadi pada setiap tahapan validasi pembersihan dengan metode Failure Mode and Effects Analysis (FMEA). Penelitian dilakukan dengan cara observasional dan wawancara langsung di salah satu industri farmasi di Kota Bandung. Tahapan kajian risiko dimulai dengan mengidentifikasi risiko, menganalisis risiko berdasarkan tingkat keparahan, memberikan skor sehingga didapatkan nilai RPN, serta mengevaluasi risiko. Dari hasil kajian risiko, didapatkan sebanyak 26 risiko dengan 16 risiko minor, 4 risiko moderat dan 6 risiko mayor. Risiko yang termasuk dalam kategori mayor dibuat tindakan pengendalian risiko untuk mengurangi risiko terjadinya kegagalan dalam validasi pembersihan. Industri farmasi dapat melakukan tindakan pencegahan dan pengendalian dari hasil kajian risiko ini seperti pengecekan terhadap sarana penunjang kritis yang ada, penentuan marker, pelaksanaan proses validasi, serta mempertimbangkan untuk pembersihan secara otomatis. 
Co-Authors Amalia Hanifa, Zahra Ami Tjitraresmi, Ami Anis Yohana Chaerunisaa, Anis Yohana Dewi, Humaira Praswatika Eli Halimah, Eli Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Hanifah Lia Aulifa, Diah Luthfiyah Rahmani, Syifa Parameswari, Natashya Puteri Agustina Pribadi, Alya Widati Aqila Rumawan, Maritsa Yasmiwar Susilawati