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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo
Anjani, Sabrina
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Medicine & Pharmacology

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Efek Ukuran Partikel terhadap Disolusi Ibuprofen Yosephine, Samuella; Intan, Nur; Anjani, Sabrina; Rahma, Shesa; Pudyastuti, Beti; Wijaya, Triyadi Hendra; Kurniawan, Dhadhang Wahyu
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.3409

Abstract

The dissolution rate is an important characteristic to consider when designing a pharmaceutical dosage form, particularly for oral medications. Ibuprofen is an oral medication with a low dissolution rate. The common solution to this problem is to increase the dose to improve drug absorption and effectiveness in order to achieve therapeutic concentration. Some methods to increase dissolution rates have been explored, such as salt formation, prodrug formation, particle size reduction, crystal modification, micellar solubilization, complex formation, solid dispersion, and self-emulsifying. This review focuses on a strategy for increasing ibuprofen dissolution rate by reducing the particle size of the drug. Reduced particle size could improve ibuprofen solubility, allowing it to be absorbed more easily and achieve the desired therapeutic effect.
Co-Authors Beti Pudyastuti, Beti Dhadhang Wahyu Kurniawan Nur Intan, Nur Rahma, Shesa Triyadi Hendra Wijaya Yosephine, Samuella