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All Journal Majalah Kedokteran Bandung Pharmaciana: Jurnal Kefarmasian Pembangunan Pedesaan Prosiding Indonesian Journal of Pharmaceutical Science and Technology Jurnal Perlindungan Tanaman Indonesia Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Sciences and Research (PSR) Mandala of Health : A Scientific Journal Jurnal of Community Health Development (JCHD) Jurnal Farmasi Indonesia Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi
Dhadhang Wahyu Kurniawan
Universitas Jenderal Soedirman Purwokerto
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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FORMULASI DAN EVALUASI BEADS METFORMIN HIDROKLORIDA MENGGUNAKAN MATRIKS PAUTAN SILANG KITOSAN-NATRIUM ALGINAT Kurniawan, Dhadhang Wahyu; Ratna Utami, Vitis Vini Fera; Permanasari, Prisci
Prosiding Vol 3, No 1 (2012)
Publisher : Prosiding

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Abstract

Kitosan merupakan salah satu polimer alami yang keberadaannya cukup melimpah, bersifat bioadesif, hidrofilik, nontoksik, kationik, biokompatibel, dan biodegradabel sangat cocok diaplikasikan dalam teknologi farmasi. Kombinasi kitosan (kationik) dengan natrium alginat (anionik) diharapkan dapat meningkatkan sifat mukoadesif kedua polimer tersebut, dapat memperlama waktu kontak obat dengan mukus sehingga dapat memperbaiki bioavailabilitas obat. Salah satu obat yang bioavailabilitasnya kurang maksimal adalah metformin hidroklorida. Tujuan penelitian ini adalah membuat formulasi beads metformin HCl menggunakan matriks pautan silang kitosan-natrium alginat, mengetahui karakteristiknya, dan memperoleh profil pelepasan obatnya. Beads metformin HCl dibuat dengan metode gelasi ionik menggunakan senyawa pentaut silang (crosslinker) sodium tripolyphospate (STPP). Konsentrasi STPP dibuat bervariasi untuk mengetahui pengaruh penambahannya terhadap karakteristik beads metformin HCl. Evaluasi yang dilakukan terhadap beads metformin HCl meliputi evaluasi sifat pengembangan (swelling behavior), morfologi partikel, persentase obat terjerap, dan uji pelepasan obat secara in vitro. Hasil penelitian menunjukkan bahwa beads metformin HCl memiliki karakteristik berserat padat, liat, dan kompak seiring bertambahnya konsentrasi STPP. Profil pelepasan metformin HCl dari beads memperilhatkan bahwa pautan silang kitosannatrium alginat dapat digunakan sebagai matriks untuk sediaan dengan pelepasan yang terkontrol. Laju pelepasan obat paling kecil ditemukan pada beads dengan penambahan konsentrasi STPP 1,5%, yang dapat melepaskan obat 100% pada waktu setelah jam ke-5.
Formulasi Tablet Efervesen dari Ekstrak Etanol Kelopak Bunga Rosella (Hibiscus sabdariffa L.) Asiani, Tri Wahyuni; Saifullah Sulaeman, Teuku Nanda; Kurniawan, Dhadhang Wahyu
Pembangunan Pedesaan Vol 12, No 1 (2012)
Publisher : Pembangunan Pedesaan

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Abstract

Rosella (Hibiscus sabdariffa L.) merupakan salah satu tanaman obat yang termasuk ke dalam famili Malvaceae. Secara empiris, Rosella berkhasiat dalam menyembuhkan berbagai macam penyakit. Penelitian ini bertujuan untuk mengetahui formula yang paling baik dalam pembuatan tablet effervescent dari ekstrak etanol kelopak bunga Rosella dengan variasi kadar Polivinilpirolidon (PVP) sebagai pengikat. Ekstrak etanol kelopak bunga Rosella dibuat menggunakan metode maserasi dalam etanol 70% dengan perbandingan 1:5. Tablet efervesen dibuat menggunakan metode granulasi basah dengan variasi PVP sebesar 0,1%, 0,5%, 1%, 5%, dan 10%. Hasil penelitian menunjukkan bahwa perbedaan kadar PVP mempengaruhi sifat fisik tablet yaitu penampilan, keseragaman ukuran, keseragaman bobot, kekerasan tablet, friabilitas, dan waktu larut. Berdasarkan hasil penelitian menunjukkan bahwa formula I yang paling baik.
Formulasi dan Efektivitas Gel Antiseptik Tangan Minyak Atsiri Lengkuas (Alpinia galanga (L.) Willd.) BANU AJI WIJAYANTO; DHADHANG WAHYU KURNIAWAN; ISKANDAR SOBRI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The use of antiseptic hand gel with regards to paradigm that is healthy as well as clean practical, as an attempt to avoid the onset of infection. The volatile oil of Alpinia galanga rhizomes are known active as antibacterial. Three formulation of gels containing of 1 mL of galangal oil were made with variations of carbopol 940 from 0.5% - 2 %. Antiseptic test were done using replica methods. Data of viscosity, spread power, and adhesion were analyzed using one way ANAVA. Data of effectiveness was analyzed using one way ANAVA and if there is any differences, it will be continued by using HSD Tukey. The results showed that viscosity of gels were pseudoplastic flows. Spread power of gel preparations increased, adhesion and viscosity decreased during storage. All gel preparation showed the effectiveness of antiseptic gels because be able to reduce the number of bacterial colonies. Effectiveness of antiseptic formula that contains of carbopol 0.5% can reduce the number of colonies 70% and did not differ from the positive control which can reduce the number of colonies up to 79.37%.
Potential of Jamu in Nanotechnology Perspective as an Alternative Treatment for Covid-19 Kurniawan, Dhadhang Wahyu; Ikhsanudin, Azis
Pharmaceutical Sciences and Research Vol. 7, No. 3
Publisher : UI Scholars Hub

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Abstract

The world seems to be recovering at this time, especially because of the 2019 global coronavirus disease pandemic (COVID-19) caused by the Coronavirus 2 virus (SARS-CoV-2). This virus is similar to other β-coronaviruses through several steps to enter and bind angiotensin-converting enzyme 2 (ACE2) as the main receptor. This binding, particularly in the respiratory epithelium and alveoli of the lungs, affects harmony in human host cells. No specific vaccines and antivirals are available to date as drug investigations are still ongoing. However, many Indonesians consume herbal medicine, especially 'empon-empon' containing the Zingiberaceae family, to protect their health from COVID-19. So far, herbal medicine has shown good results to protect the Indonesian people in fighting SARS-CoV-2 empirically. In this review, we describe the characteristics of SARS-CoV-2, herbal ingredients that are active in fighting COVID-19, and applied nanotechnology challenges to COVID-19. Therefore, it is proposed to develop herbal medicine with a nanotechnology approach to increase the efficacy and potential of herbal medicine in fighting COVID-19. Moreover, the development of nanotechnology for Indonesian jamu will increase the value of Indonesian jamu and raise its reputation in the world.
Artificial Intelligence toward Personalized Medicine Gifari, Muhammad Wildan; Samodro, Pugud; Kurniawan, Dhadhang Wahyu
Pharmaceutical Sciences and Research Vol. 8, No. 2
Publisher : UI Scholars Hub

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Abstract

In current medical practice when a patient feels symptoms he/she would consult the doctor. The doctor then gives medication in a one-fits-all fashion. However, recent genetics studies had shown that different genetic makeup can results in different effects on medication, so the medication should be customed for every individual. The main idea of “personalized medicine” is to provide the right intervention including medication to the right patient at the right time and dose. With this approach, the medication paradigm would shift from curative to preventive. The rise of personalized medicine had been possible because the information from ever-increasing biomolecular (proteomics, genomics, and other omics) and health-related data are successfully “mined” by Artificial Intelligence (AI) tools. In this paper, we proposed that AI systems toward personalized medicine must have acceptable performance, be readily interpretable by the clinical community, and be validated in a large cohort. We examined a few landmark papers with the keyword “AI for personalized medicine application”; 1) automatic image-based patient classification, 2) automatic gene-based cancer classification, and 3) automatic health-record heart failure with preserved ejection fraction patient phenotyping. All the examples are evaluated by their performance, interpretability, and clinical validity. From the analysis, we concluded that AI for personalized medicine could benefit by five factors: (1) standardization and pooling of genetics and health data, nationally and internationally, (2) the use of multi-modalities data, (3) disease specialist to guide the development of AI model, (4) investigation of AI-finding by clinical community, and (5) follow-up of AI-finding by the large clinical trial.
Evaluasi Mutu Tablet Parasetamol Generik yang Beredar di Wilayah Purwokerto Fitri Herline; Sri Sutji Susilowati; Dhadhang Wahyu Kurniawan
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 1 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (445.293 KB) | DOI: 10.35617/jfionline.v12i1.46

Abstract

Parasetamol atau asetaminofen adalah obat yang dapat digunakan untuk menurunkan demam. Selain itu parasetamol juga dapat digunakan untuk sakit kepala dan sakit ringan. Penelitian ini bertujuan untuk mengetahui persyaratan fisik dan laju disolusi tablet parasetamol generik yang beredar di wilayah Purwokerto. Metode penelitian ini adalah eksperimen dengan sampel tablet parasetamol generik yang beredar di wilayah Purwokerto. Evaluasi terhadap tablet parasetamol tersebut meliputi keseragaman ukuran, keseragaman bobot, kekerasan, kerapuhan, waktu hancur, penetapan kadar, dan uji disolusi. Uji disolusi dilakukan menggunakan tipe dayung pada kecepatan 50 rpm. Medium disolusi yang digunakan dapar fosfat pH 5,8 ± 0,5 sebanyak 900 mL. Sampel yang diperoleh pada menit ke 5, 10, 15, 20, 30, 45, dan 60 diukur absorbansinya pada spektrofotometer UV-Vis pada panjang gelombang maksimum parasetamol (243 nm). Pengungkapan data disolusi dilihat melalui nilai konsentrasi pada t=30 menit dimana tablet parasetamol pada t=30 menit tidak kurang dari 85%. Analisis data dilakukan secara deskriptif, dibandingkan dengan persyaratan tablet menurut Farmakope Indonesia dan pustaka yang lain. Hasil penelitian menunjukkan bahwa tablet Parasetamol generik memenuhi persyaratan sediaan tablet menurut farmakope indonesia meliputi keseragaman ukuran, keseragaman bobot, kekerasan, kerapuhan, waktu hancur, dan penetapan kadar. Uji disolusi untuk semua tablet Parasetamol generik memenuhi persyaratan 85%.
PENGGUNAAN TEPUNG AGAR SEBAGAI PENGIKAT DALAM TABLET ANTIDIABETES EKSTRAK ETANOL BAWANG MERAH Dhadhang Wahyu Kurniawan; Adi Yugatama; Rahajeng Puput Aryani
Kartika : Jurnal Ilmiah Farmasi Vol 1 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v1i1.25

Abstract

Bawang merah telah terbukti secara empirik dan ilmiah memiliki khasiat sebagai antidiabetes. Diabetes mellitus merupakan penyakit serius dan menjadi salah satu penyebab kematian di berbagai negara berkembang. Dalam perkembangannya telah banyak penelitian mengenai bawang merah sebagai antidiabetes. Tujuan penelitian ini adalah memformulasi sediaan tablet dari ekstrak bawang merah sebagai antidiabetes dengan menggunakan bahan pengikat tepung agar. Tablet ekstrak etanol bawang merah ini dibuat dengan menggunakan metode granulasi basah yang memvariasikan jumlah tepung agar. Hasil penelitian menunjukkan bahwa tablet ekstrak etanol bawang merah dengan bahan pengikat tepung agar yang telah dibuat memenuhi persyaratan fisik sesuai standar farmakope Indonesia dan beberapa literatur standar. Tablet yang dihasilkan berwarna coklat, memenuhi persyaratan ketika dilakukan pemeriksaan fisik meliputi, sifat alir granul, keseragaman ukuran tablet, keseragaman bobot tablet, kekerasan tablet, friabilitas tablet, dan waktu hancur tablet. Berdasarkan hasil analisis statistik ANAVA satu arah dengan derajat kepercayaan 95% menunjukkan bahwa variasi penambahan jumlah tepung agar (0,5%, 1,0%, 1,5%, dan 2,0%) kurang memberikan perbedaan yang bermakna antar formula tablet.
Efek Ukuran Partikel terhadap Disolusi Ibuprofen Yosephine, Samuella; Intan, Nur; Anjani, Sabrina; Rahma, Shesa; Pudyastuti, Beti; Wijaya, Triyadi Hendra; Kurniawan, Dhadhang Wahyu
Acta Pharmaciae Indonesia Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.3409

Abstract

The dissolution rate is an important characteristic to consider when designing a pharmaceutical dosage form, particularly for oral medications. Ibuprofen is an oral medication with a low dissolution rate. The common solution to this problem is to increase the dose to improve drug absorption and effectiveness in order to achieve therapeutic concentration. Some methods to increase dissolution rates have been explored, such as salt formation, prodrug formation, particle size reduction, crystal modification, micellar solubilization, complex formation, solid dispersion, and self-emulsifying. This review focuses on a strategy for increasing ibuprofen dissolution rate by reducing the particle size of the drug. Reduced particle size could improve ibuprofen solubility, allowing it to be absorbed more easily and achieve the desired therapeutic effect.
Effectiveness of Training on Improving Knowledge of Non Communicable Diseases Cadres Rempoah Village Baturraden District Banyumas Regency Rahayu, Eva; Kurniawan, Dhadhang Wahyu; Shodiq, Dalhar
Jurnal of Community Health Development Vol 1 No 01 (2020): Journal Of Community Health Development terbitan bulan Juli 2020
Publisher : Universitas Jenderal Soedirman, Jurusan Keperawatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (597.059 KB) | DOI: 10.20884/1.jchd.2020.1.01.2708

Abstract

Penyakit tidak menular (PTM) telah menjadi masalah kesehatan masyarakat secara global, regional, nasional dan lokal. Pemberdayaan masyarakat melalui Program Pos Pembangunan Terpadu (Posbindu) PTM adalah salah satu strategi dalam menekan jumlah insiden PTM. Pelatihan untuk kader PTM Posbindu diharapkan dapat menambah pengetahuan sasaran dalam mengorganisir Posbindu PTM di Kabupaten Banyumas. Tujuan penelitian ini adalah untuk mengetahui efektivitas pelatihan peningkatan pengetahuan kader PTM Posbindu di Desa Rempoah, Kabupaten Banyumas. Penelitian ini menggunakan desain pra-eksperimental. Populasinya adalah kader PTM Posbindu di Desa Rempoah, Kabupaten Banyumas. Metode pengambilan sampel menggunakan teknik random sampling dengan jumlah sampel 20 orang. Analisis data menggunakan uji wilcoxon. Hasil penelitian menunjukkan nilai p pengetahuan sebelum dan sesudah pelatihan adalah: 0,000. Kesimpulan dari penelitian ini adalah pelatihan kader efektif meningkatkan pengetahuan kader PTM Posbindu.
Isolation, Characterization, and Selection of Bacillus sp. from Shallot Rhizosphere that Inhibits Fusarium oxysporum Growth Saputra, Alil; Prihatiningsih, Nur; Djatmiko, Heru Adi; Kurniawan, Dhadhang Wahyu
Jurnal Perlindungan Tanaman Indonesia Vol 28, No 1 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpti.89634

Abstract

Bacillus sp. is a Plant Growth Promoting Rhizobacteria (PGPR) species that lives in the rhizosphere. This bacterium can produce antifungal compounds that suppress pathogenic fungi, such as Fusarium oxysporum. The aim of this research was isolate, characterize, and obtain Bacillus sp. that can inhibit F. oxysporum which causes twisted disease in shallots. Isolation was done by sampling 10 g of soil from shallot roots, placing it in 9 mL of sterile water, and carrying out a series of dilutions. The first dilution was incubated at 80 °C for 20 minutes to obtain Bacillus sp. on the selective medium HiChrome. Colony morphology, shape, cell color, Gram staining, catalase and endospore staining were observed from obtained isolates. An antagonist test was done to determine the inhibitory effects of isolates against the pathogenic fungus F. oxysporum. Four isolates of Bacillus sp. were obtained with irregular colony shape, dull white color without muccus, edges varying in shape between lobate and undulate, and raised elevation. The results of the antagonist test showed that the four isolates had the ability to inhibit the growth of the pathogenic fungus F. oxysporum with the greatest inhibition shown by isolate BM1 at 30.12%, with an antibiosis mechanism and hyphae swelling.
Co-Authors Anjani, Sabrina ARI WAHYUDI Azis Ikhsanudin BANU AJI WIJAYANTO Beti Pudyastuti, Beti Cahyaningrum, Putri Khaerani Dalhar Shodiq, Dalhar Daniel, Vino Darmawan, Anton Budhi Darmayan, Bella Jovita Eka Puspita Eva Rahayu Fadlilah, Synta Haqqul Farahnida, Alfia Nayudia Fitri Herline Gifari, Muhammad Wildan Hawwin, Nur Heru Adi Djatmiko Ikramina, Nabila ISKANDAR SOBRI Krisniawati, Nia Nur Intan, Nur Nur Prihatiningsih Prasetya, Rahmad Aji Pratiwi, Intan Diah Prisci Permanasari Putra, Akwila Albert Dakusha Rahajeng Puput Aryani Rahajeng Puput Aryani, Rahajeng Puput Rahma, Shesa Rehana, Rehana Samodro, Pugud Saputra, Alil Sri Sutji Susilowati Suhartomo, Dalri Muhammad Sulaeman, Uyi Sunarto Sunarto Teuku Nanda Saifullah Sulaeman Teuku Nanda Saifullah Sulaeman, Teuku Nanda Saifullah Tri Wahyuni Asiani Triyadi Hendra Wijaya Vitis Vini Fera Ratna Utami Widhi, Anriani Puspita Karunia Ning Wulandari, Annisa Dyah Yogi Ramadhani Yosephine, Samuella Yudhawan, Indra