Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Pharmacy Reports Bandung Conference Series: Business and Management
Febriyanti, Kharisma
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Pengaruh Celebrity Endorser dan Citra Merek terhadap Keputusan Pembelian pada Kosmetik Skincare Merek Azarine Febriyanti, Kharisma; Tresnati, Ratih; Saraswati, Nindya
Bandung Conference Series: Business and Management Vol. 3 No. 2 (2023): Bandung Conference Series Business and Management
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsbm.v3i2.9436

Abstract

Abstract. This study aims to determine Celebrity endorser and Brand Image on Azarine Brand Skincare Cosmetics in Bandung City and to find out respondents' responses regarding Celebrity endorser and Brand Image and to find out how much influence Celebrity endorser and Brand Image have on Purchasing Decisions on Azarine Brand Skincare Cosmetics in Bandung City. This type of research uses descriptive and verification methods, uses a quantitative approach by operating the calculations using the IBM SPSS V26 program and the sampling technique uses probability sampling to be precise using simple random sampling. Then get a sample of 100 people from the existing population. The population in this study were consumers who had purchased Azarine Brand Skincare Cosmetics. The data analysis method in this study uses multiple linear regression analysis with the aim of knowing the direction of the relationship between the Celebrity endorser (X1) and Brand Image (X2) variables with the Purchase Decision variable (Y). Thus the result is that the Celebrity endorser variable partially has a significant effect on Purchasing Decisions. Then Brand Image partially has a significant effect on Purchasing Decisions. As well as the Celebrity endorser and Brand Image variables simultaneously have a significant effect on the Purchase Decision of Azarine Skincare Brand Cosmetics in the City of Bandung. Abstrak. Penelitian ini bertujuan untuk mengetahui Celebrity endorser dan Citra Merek pada Kosmetik Skincare Merek Azarine di Kota Bandung dan untuk mengetahui tanggapan responden mengenai Celebrity endorser dan Citra Merek serta mencari seberapa pengaruh antara Celebrity endorser dan Citra Merek terhadap Keputusan Pembelian pada Kosmetik Skincare Merek Azarine di Kota Bandung. Jenis penelitian ini menggunakan metode deskriptif dan verifikatif, dengan menggunakan pendekatan kuantitatif dengan mengoperasikan perhitungannya menggunakan program IBM SPSS V26 dan teknik penarikan sampel menggunakan probability sampling tepatnya menggunakan simple random sampling. Kemudian di dapat sampel sebanyak 100 orang dari populasi yang ada. Populasi dalam penelitian ini adalah konsumen yang pernah melakukan pembelian Kosmetik Skincare Merek Azarine. Metode analisis data dalam penelitian ini menggunakan analisis regresi linier berganda dengan tujuan untuk mengetahui arah hubungan antara variabel Celebrity endorser (X1) dan Citra Merek (X2) dengan variabel Keputusan Pembelian (Y). Dengan demikian didapat hasil bahwa variabel Celebrity endorser secara parsial berpengaruh signifikan terhadap Keputusan Pembelian. Kemudian Citra Merek secara parsial berpengaruh signifikan terhadap Keputusan Pembelian. Serta variabel Celebrity endorser dan Citra Merek secara simultan berpengaruh signifikan terhadap Keputusan Pembelian Kosmetik Skincare Merek Azarine di Kota Bandung.
Molecular docking of capsaicin and its derivatives as acetylcholinesterase (AChE) inhibitors in Alzheimer disease Syah, Vicky Ardian; Geralda, Rifka; Sakti, Nickyta Salsabila Ira; Febriyanti, Kharisma; Bokshow, Rency Violita Vanden; Wulandari, Valentri; Hasanah, Siti Fadhilatul; Fadillah, Muhammad Zakki; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 4 No. 1 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.74

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder predominantly affecting older adults, characterized by pathological processes that include excessive acetylcholinesterase (AChE) activity leading to depleted acetylcholine levels. Although synthetic AChE inhibitors such as donepezil are used therapeutically, their clinical application is often limited by adverse effects and high costs. Capsaicin, a bioactive compound derived from chili peppers, has exhibited neuroprotective properties—including cognitive enhancement and amyloid-β reduction—suggesting its potential as a natural alternative for AD treatment. This study investigated capsaicin and six structural derivatives as potential AChE inhibitors through in silico molecular docking simulations against the human AChE crystal structure (PDB: 4EY7), using donepezil as a reference ligand. The docking protocol was validated with a root-mean-square deviation (RMSD) value of 0.71 Å, confirming reproducibility and reliability. The calculated binding affinities of the evaluated compounds ranged from –6.13 to –11.60 kcal/mol. Among them, 2-Hydroxy-3-(octyloxy)phenyl-5-(acrylamido)methylbenzophenone (Compound 2) exhibited the strongest binding affinity (–11.60 kcal/mol), slightly exceeding that of donepezil (–11.45 kcal/mol). Compound 2 formed four hydrogen bonds within the active site and shared key interactions with residues Phe338 and Trp286, consistent with the binding mode of donepezil. These results suggest that Compound 2 may serve as a potent natural AChE inhibitor and warrant further investigation as a candidate for Alzheimer’s disease therapy.
Co-Authors Anjar Hermadi Saputro Bokshow, Rency Violita Vanden Fadillah, Muhammad Zakki Geralda, Rifka Hasanah, Siti Fadhilatul Ratih Tresnati Sakti, Nickyta Salsabila Ira Saraswati, Nindya Syah, Vicky Ardian Winni Nur Auli Wulandari, Valentri