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All Journal SENTRI: Jurnal Riset Ilmiah Journal for Quality in Public Health Jurnal Farmasi Sains dan Teknologi
Hasanah, Yesi Ihdina Fityatal
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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Incidence of Chronic Kidney Failure and Alcohol Consumption: Meta Analysis Atmojo, Joko Tri; Yuliyanto, Dwi Joko; Hasanah, Yesi Ihdina Fityatal; Widiyanto, Aris; Anasulfalah, Hakim; Mubarok, Ahmad Syauqi
Journal for Quality in Public Health Vol. 7 No. 2 (2024): May
Publisher : Master of Public Health Program Institut Ilmu Kesehatan STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/jqph.v7i2.496

Abstract

One of the main risk factors for chronic kidney disease (CKD) is excessive alcohol consumption. Alcohol consumption can damage the kidneys and disrupt their function because the kidneys filter toxins and waste products from the blood. This study aims to estimate the magnitude of the relationship between alcohol consumption and the incidence of chronic kidney failure. This research is a systematic review and meta analysis with PICO as follows, population: Adults. Intervention: alcohol consumption, Comparison: no alcohol consumption. Outcome: chronic failure events. The articles used in this research were obtained from three databases, namely Google Scholar, Pubmed, and Science Direct. Keywords to search for articles are "Alcohol" AND "Chronic Kidney Disease" OR CKD AND Multivariate. Articles used from 2018 – 2023. Article selection was carried out using the PRISMA flow diagram. Articles were analyzed using the Review Manager 5.3 application. A total of 6 cohort studies, namely Asia and Europe, were selected for systematic review and meta analysis. Cohort studies show that alcohol consumption influences the incidence of CKD. Patients who consume alcohol have a risk of experiencing CKD that is 1.05 times compared to those who do not consume alcohol, but the resulting increase in risk is not statistically significant (aHR= 1.04 95% CI= 0.85 to 1.27; p= 0.710). Forest Plot also shows heterogeneity of effect estimates between primary studies I2= 84%; p= 0.040, which means that the estimated effect between primary studies in this meta-analysis varies. Thus, the calculation of the average effect estimate was carried out using a random effect model approach.
Evaluasi DRPs dan Outcome Terapi Pada Pasien Diabetes Mellitus Tipe 2 Dengan Penyakit Penyerta Hipertensi Stage 2 Ningrum, Andriani Noerlita; Hasanah, Yesi Ihdina Fityatal; Novitasari, Meliana; Taniar, Bella Sinta Sheila
Jurnal Farmasi Sains dan Teknologi Vol. 1 No. 01 (2023): Jurnal Farmasi Sains dan Teknologi
Publisher : PC Ikatan Apoteker Indonesia (IAI) Karanganyar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65117/w8em5w81

Abstract

Diabetes Mellitus tipe 2 (DM tipe 2) dan hipertensi stage 2 seringkali saling terkait, memberikan dampak serius terhadap kesehatan pasien. Manajemen pasien memerlukan evaluasi Drug-Related Problems (DRPs). DRPs dapat mempengaruhi outcome terapi, kepatuhan pasien, dan hasil kesehatan secara keseluruhan. Penelitian non-eksperimental dilakukan di Rumah Sakit Islam Klaten pada April 2022. Data retrospektif pasien DM tipe 2 dengan hipertensi stage 2 dianalisis secara deskriptif dengan mengacu pada standar American Diabetes Association, Medscape, dan American Society of Hospital Pharmacist. Dari 9 pasien, mayoritas berusia 46–55 tahun (66,67%) dan perempuan (77,78%). Penggunaan obat antidiabetika terbanyak yaitu Novorapid flexpen (66,67%), sementara antihipertensi terbanyak yaitu Amlodipin (66,67%). Evaluasi DRPs menunjukkan 1 interaksi obat (11,11%), terjadi pada kombinasi Candesartan, Bisoprolol, dan Furosemid. Outcome terapi menunjukkan penurunan tekanan darah rata-rata sebesar 35,89/13,56 mmHg. Evaluasi DRPs pada pasien DM tipe 2 dengan hipertensi stage 2 penting untuk meningkatkan kualitas pengobatan. Penanganan DRPs dapat meningkatkan outcome terapi dan hasil kesehatan pasien.
Analisis Profil Metabolit Ekstrak Etanol Gracilaria verrucosa Menggunakan Liquid Chromatography–High Resolution Mass Spectrometry Ningrum, Andriani Noerlita; Hasanah, Yesi Ihdina Fityatal
SENTRI: Jurnal Riset Ilmiah Vol. 4 No. 11 (2025): SENTRI : Jurnal Riset Ilmiah, November 2025
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/sentri.v4i11.4771

Abstract

Gracilaria verrucosa is a red alga with promising potential as a source of bioactive metabolites. Previous studies have mainly reported antioxidant or antibacterial activity and total phenolic content without resolving specific molecular entities. This study aimed to generate a non-targeted LC–HRMS profile of semi-polar secondary metabolites from the ethanol extract of G. verrucosa and to annotate dominant ion features into defined chemical classes. Dried biomass was macerated with 96% ethanol and analysed using UHPLC–Orbitrap HRMS in Full MS/dd-MS² mode. After QC filtering, 325 ion features were detected; 51 could be annotated with Schymanski level 2–3 confidence into five classes: oxylipins/jasmonate derivatives, phytosterols, ionone-type apocarotenoids, phenolic–flavonoids, and carnitine-conjugated lipids. Representative candidates included jasmonic acid, 6-hydroxy-3-oxo-α-ionone, cholesteryl triol, flavonoid derivatives, and eicosadienoylcarnitine. These results indicate that the semi-polar metabolome of G. verrucosa is enriched in signalling-related oxylipins and sterols, antioxidant phenolic scaffolds, and acylcarnitines linked to energy metabolism, thereby providing a more mechanistic basis for its reported bioactivities. To our knowledge, this is the first comprehensive LC–HRMS-based metabolite map of Indonesian G. verrucosa, and it offers a chemically resolved framework to support subsequent fractionation, isolation, structural elucidation, and targeted pharmacological studies.
Co-Authors Anasulfalah, Hakim Dwi Joko Yuliyanto Joko Tri Atmojo Mubarok, Ahmad Syauqi Ningrum, Andriani Noerlita Novitasari, Meliana Taniar, Bella Sinta Sheila Widiyanto, Aris