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All Journal Majalah Obstetri dan Ginekologi Asian Journal of Health Research
Widowati, Ayu Rizky
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Comprehensive Analysis of Phytoestrogens Intervention in Osteoporosis Management: A Systematic Review of Randomized Controlled Trials Widowati, Ayu Rizky
Asian Journal of Health Research Vol. 2 No. 3 (2023): Volume 2 No 3 (December) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i3.134

Abstract

Introduction: Osteoporosis is a medical condition characterized by increased bone turnover and decreased bone mass, which leads to bone fractures. Antiresorptive therapy, hormone replacement therapy (HRT), and bisphosphonates are used as first-line therapy related to numerous side effects. The osteoprotective properties of phytoestrogens are well known. This systematic review aims to explore the potential of phytoestrogen in the management of osteoporosis patients based on serum bone biomarker analysis. Methods: The literature search was conducted in six databases. The outcome of interest measures the mean changes in bone mineral density (BMD) and other serum bone biomarkers. Various forms of phytoestrogen intervention were used, including isoflavone extracts with an administered dose (tablets, capsules), genistein extract (tablets), resveratrol, and isolated soy protein (IBS) in powder form, beverages, food and snacks, and soy products. Quality appraisal was done using the Cochrane Risk of Bias Tool 2. Ten articles were included in the systematic review. Results: Seven studies found the mean changes in BMD values were significantly higher than the control group's after phytoestrogen intervention. Phytoestrogens dramatically boost numerous bone formation markers, including calcium, phosphorus, Ca/P ratio, and vitamin D, followed by a drop in BAP and osteocalcin levels. Phytoestrogens dramatically increased numerous bone formation markers, including calcium, phosphorus, Ca/P ratio, and vitamin D, followed by a decrease in BAP and osteocalcin levels. Furthermore, intervention may reduce bone resorption indicators such as CTX, RANKL, AKP, OPG, DPD, and PTH. Conclusion: Phytoestrogen intervention has demonstrated effectiveness in increasing bone mineral density and serum bone biomarkers.
Nutritional status, hemoglobin, and albumin levels in predicting platinum resistance in ovarian cancer at Dr. Saiful Anwar Hospital, Malang, Indonesia Nurseta, Tatit; Widowati, Ayu Rizky
Majalah Obstetri & Ginekologi Vol. 32 No. 3 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V32I32024.168-173

Abstract

HIGHLIGHTS Nutrition status, hemoglobin, and albumin levels are not predictors for platinum resistance. Hemoglobin and albumin levels increased in both platinum-sensitive or platinum-resistant.   ABSTRACT Objective: This study aimed to determine whether nutritional status, hemoglobin, and albumin levels could serve as reliable predictors for predicting platinum resistance in patients with ovarian cancer. Materials and Methods: Conducted as a cross-sectional analysis, this study included 80 ovarian cancer patients who had completed six cycles of platinum-based chemotherapy. Patients were divided into two categories: those with platinum-resistant cancer and those with platinum-sensitive cancer, based on recurrence status following chemotherapy. Nutritional status was assessed through body mass index (BMI), and both hemoglobin and albumin levels were measured pre- and post-chemotherapy to investigate potential differences between the groups. Results: The analysis revealed no significant difference in BMI between the platinum-sensitive and platinum-resistant groups (p = 0.743), suggesting that nutritional status, as measured by BMI, did not correlate with platinum resistance. Hemoglobin levels were similarly non-significant before (p = 0.072) and after chemotherapy (p = 0.055), indicating no clear association between hemoglobin levels and platinum response. However, hemoglobin levels showed significant increases post-chemotherapy in both the platinum-sensitive (p = 0.002) and platinum-resistant (p = 0.025) groups, though without affecting resistance outcomes. Pre-chemotherapy albumin levels did not significantly differ between the two groups (p = 0.218); but a significant post-chemotherapy difference was observed (p = 0.027), with both groups experiencing substantial increases from pre- to post-chemotherapy (p = 0.000). Conclusion: The findings suggest that BMI, hemoglobin, and albumin levels are not reliable predictors of platinum resistance in ovarian cancer patients. Although both hemoglobin and albumin increased significantly after chemotherapy, these changes did not correspond with platinum resistance status.
Pregnancy With Severe Thrombocytopenia Caused by HELLP Syndrome and Acute Idiopathic Thrombocytopenic Purpura: a Case Report Widowati, Ayu Rizky; Firdaus, Wildan Aulia; Hariyati, Suheni Ninik; Hermanto, Djoko Heri
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.183

Abstract

Introduction: Thrombocytopenia in pregnancy could result in a wide range of prognosis, with the worst-case being life-threatening. Thrombocytopenia in pregnancy is a rare condition which could result in bleeding, endangering both maternal and foetal components. During pregnancy, thrombocytopenia could be caused by various factors, including idiopathic thrombocytopenic purpura and preeclampsia. Case Presentation: A 28-year-old pregnant woman, primigravid, gestational age 37-38 weeks old, single pregnancy, presents with fever ongoing for 12 days. A routine blood test returned a thrombocyte count of 11000/mm3. Patient received 8 units of thrombocyte concentrate with no improvement and progressive decline of thrombocyte count. Patient was assessed with severe thrombocytopenia caused by suspected dengue fever, with differential diagnoses being HELLP syndrome and idiopathic thrombocytopenic purpura. Patient was also assessed with severe preeclampsia and severe oligohydramnios. Patient’s condition improved after termination of pregnancy by caesarean section, accompanied with gradual return to normal thrombocyte count value. Conclusion: Thrombocytopenia in pregnancy could be caused by various factors, necessitating the need for a thorough medical evaluation to determine the underlying cause. A multidisciplinary and collaborative approach is highly recommended in managing pregnant women with thrombocytopenia.
Genital Tuberculosis with Pleuritis and Intra-abdominal Tuberculosis Widowati, Ayu Rizky; Indrawan, I Wayan Agung; Tantular, Rezki
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.247

Abstract

Introduction: Female Genital Tuberculosis (FGTB) is a rare but serious form of extrapulmonary tuberculosis that significantly impacts female reproductive health. It accounts for 15–20% of extrapulmonary TB cases and is found in 5–10% of infertile women. Diagnosis is often delayed due to nonspecific symptoms and the difficulty of confirming infection through histopathology. Case Presentation: A 35-year-old woman presented with abdominal pain, nausea, vomiting, vaginal discharge, and postcoital bleeding. A cervical biopsy confirmed tuberculous cervicitis, supported by systemic TB symptoms and a left pleural effusion, leading to a diagnosis of extrapulmonary TB. She was treated with a full course of anti-TB therapy and referred for fertility evaluation due to persistent amenorrhea, where hysteroscopy revealed intrauterine adhesions and granulomas, confirming suspected genital TB and suggesting Asherman’s syndrome as a complication. Conclusion: Female Genital Tuberculosis is a rare cause of infertility; early diagnosis using integrative methods and awareness of genital TB transmission are essential for timely treatment and improved reproductive outcomes.
Co-Authors Firdaus, Wildan Aulia Hariyati, Suheni Ninik hermanto, djoko heri I Wayan Agung Indrawan Tantular, Rezki Tatit Nurseta