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All Journal Jurnal Pengabdian Ilmu Kesehatan Jurnal Analis Kesehatan Kendari
Yanti Sunaidi
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Public Health

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Skrining Kesehatan Melalui Pemeriksaan Asam Urat di Kompleks Aditarina Kota Makassar Mutmainnah Abbas; Rosdiana Mus; Thaslifa Thaslifa; Yanti Sunaidi; Fitriana Fitriana
Jurnal Pengabdian Ilmu Kesehatan Vol. 3 No. 1 (2023): Maret : Jurnal Pengabdian Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jpikes.v3i1.1670

Abstract

Degenerative disease is one of the classes of diseases whose incidence is related to the degeneration process in old age whose development is directly related to time and age. This usually affects the joints, namely gout. Uric acid is the final metabolic product of purine, which is a component of nucleic acid found in the nucleus of body cells. Increased uric acid levels in the blood are not only caused by food consumed but there are several other factors, namely age, gender, body mass index, and genetics. In addition, in the elderly there is a decrease in the function of vital organs such as the liver and kidneys which can cause an increase in uric acid levels in the blood. The purpose of this study is health screening through uric acid examination. The method used was descriptive by involving 27 respondents who were willing to become subjects. The results showed that there were 10 respondents with increased uric acid examination results while 17 subjects showed normal uric acid examination results.
PERBANDINGAN INDEKS ERITROSIT PADA PENDERITA TUBERKULOSIS YANG MENJALANI PENGOBATAN FASE AWAL DAN FASE LANJUTAN SEBAGAI MONITORING RISIKO ANEMIA Yanti Sunaidi; Imelda pongsimpin; Nuramaniyah Taufiq
Jurnal Analis Kesehatan Kendari Vol. 7 No. 1 (2024): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 7 (1) Desember 2024)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46356/jakk.v7i1.335

Abstract

Tuberculosis is an infectious disease caused by the bacteria Mycobacterium tuberculosis. Tuberculosis can be treated by taking Anti-Tuberculosis Drugs (OAT). Tuberculosis treatment is divided into two phases, namely the initial phase and the advanced phase. Side effects of OAT use can cause hematological abnormalities in the blood such as anemia. The purpose of this study was to determine the comparison of erythrocytes in tuberculosis patients undergoing initial and advanced phase treatment as monitoring of anemia risk. This type of research was a comparative study. The research subjects were 30 subjects undergoing initial phase treatment and 30 subjects in advanced phase treatment obtained using the total sampling method. The results of this study obtained a normal erythrocyte index in the early phase of 21 (70%) subjects, normocytic hypochromic 6 (20%) subjects, and microcytic hypochromic 3 (10%) subjects. In comparison, the normal erythrocyte index in the advanced phase was 26 (87%) subjects and microcytic hypochromic 4 (13%) subjects. From the results of the statistical test study using the Mann-Whitney test, the Asymp. Sig. (2 tailed) value was obtained 0.000 (<0.05), which indicates that there is a comparison between the results of the erythrocyte index examination in TB patients undergoing early and advanced phase treatment so that in this study, the hypothesis H is accepted and Ho is rejected. This study concludes that more people experience anemia in the early phase of treatment than in the advanced phase of treatment.
Perbandingan Nilai Hematokrit Sebelum dan Sesudah Terapi Tirosin Kinase Inhibitor pada Pasien Chronic Myeloid Leukemia Muhammad Ihza Lisan Shidqi; Yanti Sunaidi; Eleventi Oktarina Putri; Antoni Aldo Danendra Sawal
Jurnal Analis Kesehatan Kendari Vol. 8 No. 1 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 8 (1) Desember 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

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Abstract

Chronic Myeloid Leukemia (CML) is a hematologic malignancy characterized by the presence of the Philadelphia chromosome and the BCR-ABL1 fusion gene. Tyrosine kinase inhibitors (TKIs) have revolutionized CML management, improving patient survival and quality of life. However, evidence regarding the effect of TKI therapy on simple hematologic parameters, particularly hematocrit values, remains limited. This study aimed to analyze the differences in hematocrit levels before and after TKI therapy in patients with CML. A quantitative comparative design was conducted involving 53 CML patients (32 males, 21 females) aged 19–66 years. Hematocrit values were collected from medical records at two points: prior to therapy and after twelve months of TKI treatment. Data distribution was assessed using the Shapiro-Wilk test, and comparisons were performed using a paired sample t-test with a significance level of p < 0.05. The mean hematocrit value before therapy was 29.7%, increasing to 36.7% after therapy, with an average rise of 7.0%. Of the total patients, 42 (79.2%) showed an increase in hematocrit, while 11 (20.8%) demonstrated a decrease. Statistical analysis confirmed a significant difference between pre- and post-therapy values (p < 0.001). TKI therapy significantly improves hematocrit levels in CML patients, reflecting restored hematopoiesis and improved hematologic status. Hematocrit may serve as a practical and cost-effective parameter for monitoring therapy effectiveness, especially in healthcare settings with limited access to molecular testing.
Perbedaan Kadar Tumor Necrosis Factor Alpha pada Pekerja Finishing Gitar Berdasarkan Penggunaan Alat Pelindung Diri Dan Lama Bekerja Antoni Aldo Danendra Sawal; Eleventi Oktariani Putri; Muhammad Ihza Lisan Shidqi; Yanti Sunaidi
Jurnal Analis Kesehatan Kendari Vol. 8 No. 1 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 8 (1) Desember 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

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Abstract

Debu kayu dan zat kimia dari pengecatan gitar selama proses finishing yang masuk ke saluran pernapasan dapat mengaktifkan sistem imun seluler dan saat terjadinya inflamasi menyebabkan pelepasan sitokin pro-inflamasi yaitu Tumor Necrosis Factor Alpha (TNF-α). TNF-α merupakan sitokin pro-inflamasi yang memiliki efek agregasi dan stimulasi neutrofil. TNF-α disekresikan oleh makrofag, yang berperan dalam metabolisme, termasuk diferensiasi, apoptosis, proliferasi sel, koagulasi, dan metabolisme lipid. Penelitian ini merupakan penelitian observasional, dengan rancangan penelitian potong lintang di desa gitar Sukoharjo. Sampel penelitian sebanyak 30 subjek, diambil menggunakan teknik non-probability sampling dengan metode purposive sampling. Pemeriksaan TNF-α dilakukan dengan metode Enzyme-Linked Immunosorbent Assay (ELISA). Hasil penelitian menunjukkan bahwa nilai rata-rata TNF-α pada pekerja finishing gitar yang memakai APD dengan masa kerja 1-3 tahun adalah 66,66 pg/ml, sedangkan pada pekerja yang memakai APD dengan masa kerja >3 tahun adalah 70,71 pg/ml. Nilai rata-rata pada pekerja yang tidak memakai APD dengan masa kerja 1-3 tahun adalah 71,64 pg/ml, sedangkan pada pekerja yang tidak memakai APD selama >3 tahun adalah 86,10 pg/ml. Kesimpulan dari penelitian ini adalah terdapat perbedaan kadar TNF-α berdasarkan penggunaan APD yang bekerja selama 1-3 tahun maupun >3 tahun.
Analisis Retrospektif Hasil Pemeriksaan Tiroid (TSH dan FT4) dengan Metode ELFA di RSUD Dr. Doris Sylvanus Palangka Raya Eleventi Oktarina Putri; Antoni Aldo Danendra Sawal; Muhammad Ihza Lisan Shidqi; Yanti Sunaidi
Jurnal Analis Kesehatan Kendari Vol. 8 No. 1 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 8 (1) Desember 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

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Abstract

Thyroid disorders are among the most prevalent endocrine conditions globally, demanding precise diagnostic methodologies for effective management. Epidemiological data on thyroid disorders in Kalimantan is still limited. This study aims to re-analyze retrospective data on .thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels measured using the Enzyme Linked Fluorescent Assay (ELFA) method in 2017 at RSUD Dr. Doris Sylvanus Palangka Raya, evaluate them with the latest guidelines, and validate the ELFA method. Data from 87 patients with suspected thyroid dysfunction were subjected to descriptive statistics, Chi-square tests, Spearman's correlation, and Receiver Operating Characteristic (ROC) curve analysis. Patients were predominantly female (n=67, 77%). Hormone distribution showed a tendency towards hyperthyroidism, with 48.3% (n=42) of patients having low TSH and 27.6% (n=24) having high FT4. Statistical analysis showed no significant association between gender and TSH (χ² = 1.277, df = 2, p = 0.528) or FT4 (χ² = 3.240, df = 2, p = 0.198) levels. However, a very strong and significant physiological relationship was found between TSH and FT4 levels, both categorically (χ² = 24.576, df = 4, p < 0.001) and correlationally (r = -0.503, p < 0.001). ROC analysis proved that the ELFA method has very good diagnostic accuracy with an Area Under Curve (AUC) of 0.915 (95% CI: 0.835–0.995, p < 0.001). The profile of thyroid disorders in this region is dominated by a hyperthyroidism pattern, and historical data from the ELFA method has been proven to remain valid and clinically relevant for epidemiological studies. These findings affirm that data generated by ELFA technology in 2017 remains robust and clinically valid when interpreted through the lens of modern guidelines. The study underscores the value of simultaneous TSH-FT4 testing and supports the sustained utility of older, yet reliable, immunoassay technologies, particularly in resource-limited settings, contributing to longitudinal epidemiological understanding of thyroid disorders in the region.
Co-Authors Antoni Aldo Danendra Sawal Eleventi Oktariani Putri Eleventi Oktarina Putri Fitriana Fitriana Imelda pongsimpin Muhammad Ihza Lisan Shidqi Mus, Rosdiana Mutmainnah Abbas Taufiq, Nuramaniyah Thaslifa Thaslifa