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All Journal Majalah Kedokteran Bandung Indonesian Journal of Urology Jurnal Respirologi Indonesia
Dahlan, Muhammad Sopiyudin
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Health Professions Medicine & Pharmacology Public Health

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COMPARISON OF PHARMACOLOGY AGENTS EFFECT IN TREATING URETERAL STENT RELATED SYMPTOMS: SYSTEMATIC REVIEW & META-ANALYSIS OF RANDOMIZED CONTROLLED TRIAL¬ Mubarak, Andi As'ad; Mahfuz, Muhammad Ainul; Aziz, Abdul; Dahlan, Muhammad Sopiyudin
Indonesian Journal of Urology Vol 31 No 1 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i1.840

Abstract

Objective: We wish to update existing meta-analyses to assess the effectiveness of pharmacological agents against ureteral stent-related symptoms with better design of RCTs, as well as more valid and reliable measurement methods. Material & Methods: Relevant published articles up to February 2022 were obtained from PubMed, CENTRAL, Google Scholar, Science Direct, and DOAJ. All single-blind or double-blind RCTs with various comparisons using pharmacological agents and/or placebo in patients with ureteral stent-related symptoms, with outcome assessment using USSQ at week 1 and week 4 during stent placement was included in the study. Statistical parameter Mean Difference (MD) with 95% CI was used to measure effect size. The p value less than 0.05 indicates statistical significance. Results: Alpha blockers (2 studies, 85 samples) significantly reduced fourth week UIS compared to placebo (MD: – 5.46, 95% CI: – 7.47 to -3.46, I2 = 0%, P = < 0.001), and alpha blockers (2 studies, 42 samples) significantly reduced first week SIS compared to combination therapy (MD: – 0.82, 95% CI: – 1.56 to – 0.08, I2 = 0%, P = 0.03). The results of the meta-analysis of USSQ scores in other domains have no significant differences. Conclusion: Alpha blockers were better than placebo in reducing UIS due to ureteral stent in the fourth week of stent placement, and better than combination therapy in reducing SIS due to ureteral stent in the first-week post stenting. However, more RCTs are needed with larger samples and better designs to reach valid conclusions. Keywords: Stents, Randomized Controlled Trials as Topic, Single-Blind Method.
Diagnostic Accuracy and Clinical Utility of InaTB-Rif, Locally Developed Molecular Test for Tuberculosis, in Comparison with Xpert MTB/RIF in Indonesia Handayani, Diah; Haryanto, Budi; Adyasiwi, Galoeh; Dahlan, Muhammad Sopiyudin; Agustin, Heidi; Wardoyo, Muhammad Prasetio; Ilham, Ahmad Fadhil; Burhan, Erlina
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.907

Abstract

Background: Tuberculosis (TB) remains a significant public health issue in Indonesia. Early and accurate diagnosis and drug susceptibility testing are essential for TB management. This study compared the diagnostic accuracy of the locally developed InaTB-Rif molecular test and Xpert MTB/RIF, using Mycobacterium Growth Indicator Tube (MGIT) culture as the reference standard. Methods: A cross-sectional study was conducted at Persahabatan Hospital, Jakarta, from February to August 2023. Presumptive pulmonary TB patients were recruited and tested using Xpert MTB/RIF, InaTB-Rif, and MGIT culture. The study assessed the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and agreement between InaTB-Rif and Xpert MTB/RIF for Mycobacterium tuberculosis (MTB) detection and rifampicin resistance. Diagnostic accuracy was compared using receiver operating characteristic (ROC) curves. Results: MGIT culture identified 29 TB-positive and 26 TB-negative cases. InaTB-RIF showed a sensitivity of 93.1% (95% CI=0.77-0.99), specificity of 76.9% (95% CI=0.56-0.91), PPV of 81.8% (95% CI=0.64-0.93), and NPV of 90.9% (95% CI=0.70-0.98). Xpert MTB/RIF had a sensitivity of 89.7% (95% CI=0.726-0.978), specificity of 80.8% (95% CI=0.606-0.93), PPV of 83.9% (95% CI=0.66-0.94), and NPV of 87.5% (95% CI=0.67-0.97). The area under the curve (AUC) was 0.8501 for InaTB-RIF and 0.8521 for Xpert MTB/RIF, with no significant difference in accuracy (P=0.965). The kappa value for MTB detection was 0.776, indicating substantial agreement, while the kappa value for rifampicin resistance detection was 0.517, indicating moderate agreement. Conclusions: InaTB-RIF demonstrates comparable diagnostic accuracy to Xpert MTB/RIF with good diagnostic performance and agreement for detecting MTB and moderate agreement for rifampicin resistance detection.
Oxygen Saturation Diagnostic Accuracy Against COVID-19 in Rural Areas of Indonesia Mahfuz, Muhammad Ainul; Dahlan, Muhammad Sopiyudin; Ibrahim, Juliani; Sastinawati, Ayu
Majalah Kedokteran Bandung Vol 55, No 3 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n3.2990

Abstract

As a country with a high proportion of rural areas, Indonesia continues to struggle with a rapid and accurate diagnosis of COVID-19, necessitating the development of a diagnostic tool or parameter that is less expensive, easier to obtain, and produces rapid results. This retrospective study aimed to explore the diagnostic accuracy of oxygen saturation in detecting COVID-19 in rural areas of Indonesia. Data were collected consecutively  from medical records of adult patient (30 – 90 years old) suspected of having COVID-19 based on the WHO criteria and  underwent RT-PCR swab test in three (3) hospitals in one of the regions of Indonesia during the timeframe of May 1, 2020 to September 31, 2021. Analysis was conducted using the cross-table analysis with sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve (AUC) as the variables with their respective confidence interval. Results indicated that 548 of 700 patients included in the analysis were confirmed positive for COVID-19 based on the RT-PCR test results. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve (AUC) value of oxygen saturation for detecting COVID-19 were 33% (CI 95% 29 – 37%), 78% (CI 95% 72 – 85) %), 84% (CI 95% 80 – 89%), 24% (CI 95% 21 – 28%), and 56% (CI 95% 51– 61%), respectively.  Thus,  the oxygen saturation level alone does not have adequate diagnostic accuracy for the diagnosis of COVID-19 and, therefore, is not recommended to be used for diagnosing COVID-19.
Co-Authors Abdul Aziz Adyasiwi, Galoeh Agustin, Heidi Budi Haryanto Diah Handayani Erlina Burhan Ibrahim, Juliani Ilham, Ahmad Fadhil Mahfuz, Muhammad Ainul Mubarak, Andi As'ad Sastinawati, Ayu Wardoyo, Muhammad Prasetio