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All Journal Journal of Innovation Research and Knowledge Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Shada Adila Abadi
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Humanities Dentistry Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Nursing Public Health Social Sciences Veterinary

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Tinjauan Penggunaan Teknik Kromatografi untuk Memisahkan dan Memurnikan Senyawa Aktif Secara Efisien Nur Rifa Ashya; Aida Savitri; Annisa Annisa; Difa Az-Zahra; Nurul Hasni Julianti; Shada Adila Abadi; Yumna Zaida
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3145

Abstract

Indonesia boasts an incredible wealth of biodiversity, positioning it as a promising source of natural compounds with significant biological activities. Its flora harbors a wide array of secondary metabolites including alkaloids, flavonoids, phenolic compounds, and terpenoids that hold immense potential for pharmaceutical and health applications. However, to utilize these bioactive molecules effectively, efficient methods for their extraction, separation, and purification are essential. Chromatography techniques such as thin-layer chromatography (TLC), column chromatography, and high-performance liquid chromatography (HPLC) are widely recognized as the most effective approaches for isolating and characterizing these valuable compounds. This article offers a comprehensive review of the existing literature on the chromatographic processes applied in isolating active constituents from medicinal plants. It systematically examines different methodologies adopted for extraction, separation, and identification, critically assessing their strengths and limitations. The review covers how plant materials are prepared, solvents and mobile phases optimized, stationary phases selected, and detection systems employed to achieve high-purity isolates. By comparing outcomes across studies, it illustrates the efficiency of TLC in preliminary screening, the flexibility of column chromatography in bulk separation, and the high resolution and reproducibility offered by HPLC. Results from multiple research efforts demonstrate that these chromatographic techniques can consistently yield pure compounds suitable for further pharmacological testing. The purified isolates not only exhibit potential therapeutic effects but also meet quality standards necessary for development into safe and effective natural medicines. The review highlights best practices in methodology selection, solvent systems, and instrument conditions tailored to specific metabolite classes. Ultimately, this synthesis emphasizes that chromatography plays a pivotal role in unlocking the pharmaceutical potential of Indonesia’s natural biodiversity.
FORMULASI DAN EVALUASI SIFAT FISIK LIP GLOSS TINTA CUMI (LOLIGO SP) Putri, Audy Apriliana; Fayza Nindya Nur’Assyfa; Muhammad Ridha; Nurul Hasni Julianti; Shada Adila Abadi; Yulianita Pratiwi Indah Lestari
Journal of Innovation Research and Knowledge Vol. 4 No. 3: Agustus 2024
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jirk.v4i3.8277

Abstract

Tinta cumi memiliki berbagai manfaat dalam pemanfaatannya dalam aktivitas biologis salah satunya sebagai antioksidan, sehingga baik untuk menangkal radikal bebas, melembabkan dan menutrisi kulit bibir. Lip gloss adalah salah satu produk kosmetik yang dimana memiliki berfungsi untuk melembabkan dan memberikan efek kilau yang agak mengkilap di bibir, atau digunakan untuk memberikan efek warna tertentu. Sediaan lip gloss memiliki kaandungan minyak yang tinggi sehingga memberikan kesan melembabkan, berkilau atau glossy dengan bentuk cair dan padatan lunak. Tujuan dari penelitian ini adalah untuk mengetahui sifat fisik dari sediaan lip gloss tinta cumi yang dibuat dengan berbagai konsentrasi formula dengan kontrol negatif dan kontrol positif. Kontrol negatif F0, konsentrasi 0,5% F1, konsentrasi 1% F2, konsentrasi 1,5% F3, dan kontrol negatif F4. Pembuatan ekstak tinta cumi menggunakan metode refluks kemudian dilanjutkan dengan formulasi sediaan dan uji sifat fisik sediaan meliputi uji organoleptis, uji homogenitas, uji ph, uji daya sebar, dan uji viskosistas. Hasil dari semua uji didapat yaitu formulasi 2 dengan konsentrasi 1% ekstrak serbuk tinta cumi yang memiliki sifat fisik terbaik dengan beberapa uji yang dilakukan
Co-Authors Aida Savitri Annisa Annisa Difa Az-Zahra Fayza Nindya Nur’Assyfa Muhammad Ridha Nur Rifa Ashya Nurul Hasni Julianti Putri, Audy Apriliana Yulianita Pratiwi Indah Lestari Yumna Zaida