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All Journal Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Vitamedica: Jurnal Rumpun Kesehatan Umum
Aida Savitri
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Dentistry Health Professions Nursing Public Health Veterinary

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Studi Literatur Uji Stabilitas Fisik Berbagai Sediaan Berbasis Ekstrak Daun Kencur (Kaempferia galanga L.) Aida Savitri; Sri Muliany; Regina Nabila; Nor Latifah
VitaMedica : Jurnal Rumpun Kesehatan Umum Vol. 3 No. 3 (2025): Juli : VitaMedica : Jurnal Rumpun Kesehatan Umum
Publisher : STIKES Columbia Asia Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62027/vitamedica.v3i3.410

Abstract

Galangal (Kaempferia galanga L.) is a herbal plant known to have anti-inflammatory, antibacterial, and antioxidant activities. The use of galangal extract in topical pharmaceutical preparations such as ointments, gels, and creams requires attention to the physical stability of the preparation to ensure the effectiveness and safety of the product. This study aims to examine the physical stability of various forms of galangal extract-based preparations through literature studies from three relevant journals. The method used is a descriptive literature study by analyzing the results of physical stability tests (organoleptic, pH, homogeneity, spreadability, adhesion, and viscosity) of ointments, gels, and creams. The results of the study showed that the gel form with a carbopol base provided the best overall physical stability, followed by an ointment with a water-washed base. Meanwhile, sunscreen cream made from galangal and seaweed showed quite good stability, although its spreadability and adhesion still need to be improved. This study provides an overview that the form and composition of the preparation greatly affect the physical stability of galangal extract, as well as the importance of choosing the right base in the formulation.
Tinjauan Penggunaan Teknik Kromatografi untuk Memisahkan dan Memurnikan Senyawa Aktif Secara Efisien Nur Rifa Ashya; Aida Savitri; Annisa Annisa; Difa Az-Zahra; Nurul Hasni Julianti; Shada Adila Abadi; Yumna Zaida
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3145

Abstract

Indonesia boasts an incredible wealth of biodiversity, positioning it as a promising source of natural compounds with significant biological activities. Its flora harbors a wide array of secondary metabolites including alkaloids, flavonoids, phenolic compounds, and terpenoids that hold immense potential for pharmaceutical and health applications. However, to utilize these bioactive molecules effectively, efficient methods for their extraction, separation, and purification are essential. Chromatography techniques such as thin-layer chromatography (TLC), column chromatography, and high-performance liquid chromatography (HPLC) are widely recognized as the most effective approaches for isolating and characterizing these valuable compounds. This article offers a comprehensive review of the existing literature on the chromatographic processes applied in isolating active constituents from medicinal plants. It systematically examines different methodologies adopted for extraction, separation, and identification, critically assessing their strengths and limitations. The review covers how plant materials are prepared, solvents and mobile phases optimized, stationary phases selected, and detection systems employed to achieve high-purity isolates. By comparing outcomes across studies, it illustrates the efficiency of TLC in preliminary screening, the flexibility of column chromatography in bulk separation, and the high resolution and reproducibility offered by HPLC. Results from multiple research efforts demonstrate that these chromatographic techniques can consistently yield pure compounds suitable for further pharmacological testing. The purified isolates not only exhibit potential therapeutic effects but also meet quality standards necessary for development into safe and effective natural medicines. The review highlights best practices in methodology selection, solvent systems, and instrument conditions tailored to specific metabolite classes. Ultimately, this synthesis emphasizes that chromatography plays a pivotal role in unlocking the pharmaceutical potential of Indonesia’s natural biodiversity.
Co-Authors Annisa Annisa Difa Az-Zahra Nor Latifah Nur Rifa Ashya Nurul Hasni Julianti Regina Nabila Shada Adila Abadi Sri Muliany Yumna Zaida