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All Journal Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan
Nur Rifa Ashya
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Dentistry Health Professions Nursing Public Health Veterinary

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Analisis Pengaruh Formulasi dan Bahan Penghancur terhadap Waktu Hancur Tablet Cheina Nazerina Yoshi; Luthfia Raisah Ahyati; Nur Rifa Ashya; Nurul Hasni Julianti; Yenni Hafizah; Nor Latifah
Jurnal Ventilator Vol. 2 No. 4 (2024): Desember : Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v2i4.1533

Abstract

Tablets are solid preparations consisting of active drug substances and fillers. The purpose of adding a crushing agent is to reduce the pressure that occurs in making tablets, especially during the tablet release process which begins with breaking it. This study aims to investigate a number of components that influence the disintegration or breaking time of tablets, such as the choice of disintegrating agent, excipient composition, and environmental conditions such as pH and temperature. The research results show that choosing the right disintegrating agent, such as starch or starch, can accelerate tablet disintegration by increasing its ability to swell in liquid. Faster disintegration times can be achieved through the addition of appropriate disintegrating agents and optimization of tablet formulation, which ultimately supports increased drug therapeutic effectiveness. The methodology employed in this analysis is predicated on a survey of the literature on electronic data sources. Based on existing literature, starch or starch granules have the ability to swell up when exposed to water, amylose also has similar properties, namely that they both function as disintegrating agents. Concluded that amylum or starch derived from various plants is effectively utilized as a tablet disintegrating agent due to its superior to interact with water, but also because the evaluation results almost all meet the established standards.
Tinjauan Penggunaan Teknik Kromatografi untuk Memisahkan dan Memurnikan Senyawa Aktif Secara Efisien Nur Rifa Ashya; Aida Savitri; Annisa Annisa; Difa Az-Zahra; Nurul Hasni Julianti; Shada Adila Abadi; Yumna Zaida
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3145

Abstract

Indonesia boasts an incredible wealth of biodiversity, positioning it as a promising source of natural compounds with significant biological activities. Its flora harbors a wide array of secondary metabolites including alkaloids, flavonoids, phenolic compounds, and terpenoids that hold immense potential for pharmaceutical and health applications. However, to utilize these bioactive molecules effectively, efficient methods for their extraction, separation, and purification are essential. Chromatography techniques such as thin-layer chromatography (TLC), column chromatography, and high-performance liquid chromatography (HPLC) are widely recognized as the most effective approaches for isolating and characterizing these valuable compounds. This article offers a comprehensive review of the existing literature on the chromatographic processes applied in isolating active constituents from medicinal plants. It systematically examines different methodologies adopted for extraction, separation, and identification, critically assessing their strengths and limitations. The review covers how plant materials are prepared, solvents and mobile phases optimized, stationary phases selected, and detection systems employed to achieve high-purity isolates. By comparing outcomes across studies, it illustrates the efficiency of TLC in preliminary screening, the flexibility of column chromatography in bulk separation, and the high resolution and reproducibility offered by HPLC. Results from multiple research efforts demonstrate that these chromatographic techniques can consistently yield pure compounds suitable for further pharmacological testing. The purified isolates not only exhibit potential therapeutic effects but also meet quality standards necessary for development into safe and effective natural medicines. The review highlights best practices in methodology selection, solvent systems, and instrument conditions tailored to specific metabolite classes. Ultimately, this synthesis emphasizes that chromatography plays a pivotal role in unlocking the pharmaceutical potential of Indonesia’s natural biodiversity.
Co-Authors Aida Savitri Annisa Annisa Cheina Nazerina Yoshi Difa Az-Zahra Luthfia Raisah Ahyati Nor Latifah Nurul Hasni Julianti Shada Adila Abadi Yenni Hafizah Yumna Zaida