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All Journal Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan
Sahril Sillehu
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Skrining Fitokimia dan Uji Aktivitas Antibakteri Ekstrak Etanol Daun Gatal (Laportea decumana) Asal Desa Waisala Terhadap Bakteri Staphylococcus aureus Risman Tunny; Epi Dusra; Sahril Sillehu; Maritje S.J Malisngorar; Anisa Muges
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 3 No. 1 (2024): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v3i1.2216

Abstract

Introduction: Itch Leaves (Laportea decumana) is a medicinal plant that grows widely in eastern Indonesia, especially Maluku. This plant usually grows in humid areas, surrounded by or adjacent to sago trees, and near rivers. Local people usually use the leaves to treat various complaints such as pain, fatigue and joint and muscle pain, or as a muscle relaxant. Objective: of this research is to determine the secondary metabolite content of the ethanol extract of itchy leaves (Laportea decumana) and test the antibacterial activity of the ethanol extract of itchy leaves (Laportea decumana) against the growth of Staphylococcus aureus bacteria. Method: Used in this research was the Agar diffusion method with itchy leaf test material using concentrations of 60%, 65%, 70% and 75%, chloramphenicol as a positive control and distilled water as a negative control. Results: research shows that itchy leaf extract (Laportea decumana) at a concentration of 60% has an inhibition zone diameter of 15.5 mm, at a concentration of 65% the diameter of the inhibition zone is 20.5 mm, at a concentration of 70% it has 25 mm, while at a concentration of 75% it has The highest area of inhibition against Staphylococcus aureus is 29 mm. Itchy leaf extract (Laportea decumana) at a concentration of 75% has a strong inhibitory level against Staphylococcus aureus bacteria, namely with an inhibitory zone diameter of 29 mm. Conclusion: There are secondary metabolite compounds in the ethanol extract of itchy leaves (Laportea decumana) and antibacterial activity against the growth of Staphylococcus aureus bacteria.
Formulasi Dan Evaluasi Sediaan Salep Luka Bakar Basis Hidrokarbon Ekstrak Etanol Daun Katang-Katang (Ipomoea Pescaprae L.) Asal Desa Seith Tahun 2023 Nur’in Aihena; Aulia Debby Pelu; Sahril Sillehu
Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan Vol. 1 No. 4 (2023): Desember : Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebida
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/corona.v1i4.116

Abstract

Background: Ointment is a semisolid preparation used as a topical medicine, which has direct access to the skin tissues. Katang-katang is one of the medicinal plants traditionally used to treat various types of wounds. Objective: The aim of this study is to identify the secondary metabolite content of katang-katang leaves (Ipomoea pescaprae L.), create and evaluate a good and stable ointment formulation pharmaceutically, and test the irritation of the ointment for burn wounds using ethanol extract of katang-katang leaves (Ipomoea pescaprae L.). Method: The method used is experimental research, the ointment formulation is made using three formulations with different concentrations of active ingredients, with a ratio of FI 20%, FII 25%, and FIII 30%. Result: The results of the study indicate that katang-katang leaves contain flavonoids, tannins, and steroids. The study determined the formulation of a burn ointment from ethanol extract of katang-katang leaves (Ipomoea pescaprae L.). The organoleptic test results of FI, FII, and FIII showed good and stable color, odor, and shape, as well as homogeneity after one week of storage. The pH values measured were 7 for all formulations even after one week of storage. The spreading power of FI was (5.52 cm), FII was (5.88 cm), and FIII was (7.23 cm), which met the standards for good formulation. The irritation tests for all three formulas were categorized as safe. Conclusion: Based on the identification test results, the katang-katang leaves were found to contain flavonoids, tannins, and steroids. The evaluation test results for the three formulations using a hydrocarbon base showed that a good and stable burn ointment could be made from the ethanol extract of katang-katang leaves (Ipomoea pescaprae L.) without causing skin irritation.
Co-Authors Anisa Muges Aulia Debby Pelu Epi Dusra Maritje S.J Malisngorar Nur’in Aihena Tunny, Risman