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All Journal Camellia Jurnal Sains dan Kesehatan
Butar-Butar, Maria Elvina Tresia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Antidepressant Activity Study of Keruing (Dipterocarpus grandiflorus) Oleoresin Candle Aromatherapy on Male Mice (Mus musculus) Balb/C Strain Agus, Adhe Septa Ryant; Butar-Butar, Maria Elvina Tresia; Fernandes, Andrian; Maharani, Rizki; Awan, Kevin Imanuel; Luhat, Martin Gilbert
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 3 No 2 (2024): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v3i2.24665

Abstract

Depression represents a manifestation of prolonged stress, which, if left untreated, may lead to severe mental disorders. For depression treatment therapy, it can be carried out based on evidence-based treatment for depression and anxiety. Aromatherapy candles can be used as a non-pharmacological medium for depression therapy, where keruing has active compounds are phthalic acid di(3-methoxybenzyl) ester and phthalic acid, 5-ethyl-1,3-dioxan-5-yl octyl ester, causing keruing oleoresin to have a distinctive fragrance. This study aims to evaluate the pharmacological potential of keruing as an antidepressant for non-pharmacological therapy. Aromatherapy candles were formulated with keruing oleoresin at concentrations of 0%, 2.5%, 5%, 7.5%, and 10%, followed by testing their antidepressant activity using the Conditioned Place Preference (CPP) method. The results of the Paired T-test for groups F0, F2, and F4 or formulas containing 0%, 5%, and 10% of keruing oleoresin have a significant effect (sig. values <0.05) between pre and post-test being given aromatherapy and induction. In the One-way ANOVA test, between their groups, it can be seen there was no significant difference in test activity, namely for the pre-treatment test (sig. 0.445 > 0.05) and for the post-treatment test (sig. 0.065 > 0.05). Results indicated that while the candles met physical quality standards outlined by the Indonesian National Standard (SNI), no significant antidepressant effects were observed in mice. Further refinement in methodology, including the concentration of active compounds and delivery methods, is recommended to enhance the pharmacological potential of keruing oleoresin.
Formulation of Keruing (Dipterocarpus grandiflorus) Oleoresin Aromatherapy Candles Butar-Butar, Maria Elvina Tresia; Agus, Adhe Septa Ryant; Leswana, Nurillahi Febria; Fernandes, Andrian
Jurnal Sains dan Kesehatan Vol. 6 No. 4 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i4.2331

Abstract

Aromatherapy is an alternative treatment method that utilizes essential oils and volatile components, such as terpenes and aromatic compounds. The active compounds of keruing oleoresin are phthalic acid, namely phthalic acid di(3-methoxybenzyl) ester and phthalic acid, 5-ethyl-1,3-dioxan-5-yl octyl ester causing keruing oleoresin to have a distinctive fragrance. The purpose of this study was to formulate keruing oleoresin in aromatherapy candle preparations. This research method includes base optimization, formulation of keruing oleoresin aromatherapy candles with concentrations of 0%; 2.5%; 5%; 7.5%; and 10%, and evaluation of aromatherapy candles including organoleptic testing, melting point, and burning time. The results of organoleptic testing of aromatherapy candles in shape, aroma, and color showed that F4 with 10% oleoresin concentration had a more dominant aroma and color. Melting point and burning time tests showed F1 with a concentration of 2.5% had a higher melting point of 54.6°C and a longer burning time of 144 minutes. Keywords:          Dipterocarpus grandiflorus, oleoresin, aromatherapy candle
Co-Authors Agus, Adhe Septa Ryant Andrian Fernandes, Andrian Awan, Kevin Imanuel Luhat, Martin Gilbert Nurillahi Febria Leswana Rizki Maharani