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EXPLANATION OF THE MOLECULAR MECHANISM OF ANTI-DEPRESSION THERAPY USING WEBINARS AS LEARNING COMMUNICATION MEDIA Adhe Septa Ryant Agus; Junaidi Khotib
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 7 No. 3 (2023): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v7i3.2023.316-325

Abstract

The Covid-19 Pandemic outbreak has changed various forms of life in society, including restrictions on activities in an open-source environment. The pandemic has also created various kinds of unresolved mental health problems, both in the national dan global area, both those who are directly exposed to the virus and those who are not. Today, the community is still struggling to control the spread of Covid-19, but on the other hand, it has caused the spread of feelings of anxiety, fear and mental pressure due to isolation, physical distancing restrictions, social relations, and other uncertainties. Therefore, these webinar activities were held as one of the online learning communication media, in terms of providing mattery regarding the molecular mechanism of antidepressant therapy, which during the post-Covid-19 pandemic its use increased due to social reasons. This webinar media was very effective without having to gather a crowd and aims to increase knowledge, especially among participants in terms of handling mental health such as depression in terms of its pharmacology therapy. Then, knowing the mechanism of molecular action can improve the optimization of antidepressant therapy according to the patient’s condition. The target participants in this webinar are health workers, students of health study programs, and common people. The webinar activity was conducted by the online system, using the Zoom meeting platform, and was held on April 15th, 2023, then was attended by 241 people, who came from all over Indonesia. From the implementation of the webinar activities, it is known that there has been an increase in understanding of the molecular matter that has been given, this can be seen from the percentage of the correct answers in the post-test evaluation compared to the answers in the pre-test.
Formulasi dan Uji Karakteristik Shampo Ekstrak Bawang Dayak (Eleutherine bulbosa (Mill).Urb. Menggunakan Karbopol 940 Sebagai Pengental. Luhung, Sisilia; Taufiqurrahman, Muh; Agus, Adhe Septa Ryant
Majalah Farmasetika Vol 9, No 5 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v9i5.57440

Abstract

Indonesia memiliki beragam jenis tanaman yang dapat digunakan sebagai bahan utama obat-obatan dalam bidang farmasi, kedokteran, kosmetika maupun pertanian. Salah satu tumbuhan yang mudah ditemukan dan khas di daerah Kalimantan dan memiliki berbagai berkhasiat salah satunya dapat digunakan mengobati penyakit bisul ataui nfeksi kulit yaitu Umbi Bawang Dayak (Eleutherine bulbosa (Mill). Urb. Penelitian ini bertujuan menguji ekstrak umbi bawang dayak (Eleutherine bulbosa (Mill) sebagai bahan utama sampo antiketombe dan mengetahui formulasi sediaan sampo Umbi Bawang Dayak (Eleutherine bulbosa (Mill).Urb. Metode dalam penelitian menggunakanrancangan laboratorik dilakukan mulai dari isolasi senyawa metabolit sekunder dengan metode maserasi bertingkat menggunakan pelarut etanol, kemudian dilakukan pembuatan sampo antiketombe Umbi Bawang Dayak dengan konsentrasi 10%,15%, dan 20%, kemudian dilakukan dan pengujian mutu fisik. Berdasarkan asil penelitian diperoleh bahwa sampo antiketombe umbi bawang dayak yang memiliki mutu fisik terbaik diantara variasi zat aktif yaitu (F1) 5 gram , (F2) 10 gram, dan (F3) 20 gram adalah F3 dengan memenuhipersyaratan uji mutu fisik dan memiliki stabilitas sampo yang baik. Dari hasil uji sampo antiketombe dinyatakan bahwa mutu fisik dari ketiga formula sampo ekstrak umbi bawang dayak meliputi homogenitas, organoleptik, pengukuran tinggi busa dan stabilitas busa, penggukuran pH, cycling test, dan viskositas.
UJI ANTIBAKTERI BAGIAN MINYAK dan AIR DESTILAT BUNGA KENANGA [Cananga odorata (L.) Hook.F. & Thoms] TERHADAP Staphylococcus epidermidis dan KESETARAANYA PADA TETRASIKLIN HCl Adhe Septa Ryant Agus; Siti Maimunah
Jurnal Insan Farmasi Indonesia Vol 6 No 2 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i2.1639

Abstract

Antibacterial tests have been carried out on the oil and water from the distillation of ylang-ylang flowers [Cananga odorata (L.) Hook.F. & Thoms] on the growth of Staphylococcus epidermidis and equivalence to the Tetracycline HCl. using the agar diffusion method and qualitative identification of chemical contents profiles using thin layer chromatography (TLC). For the oil part, there are seven stains in sequences, namely pink, dark green, brown, green blue, red purple, light green, and dark purple, with Rf being 0.13, 0.17, 0.20, 0.38; 0.45, 0.53, and 0.70. Meanwhile, for the water part, three stains formed, namely brown, red, purple, and dark purple, with Rf values of 0.20, 0.45, and 0.70. The equivalent concentration of oil parts for the test solution for the growth of Staphylococcus epidermidis with the reference Tetracycline HCl was 0.563, 0.724, and 0.857ppm. Meanwhile, the equivalent concentration for the water part was 0.413, 0.390 and 0.368ppm. This analysis found that for the oil part of the test solution, there was a significant difference in the inhibitory power of the growth of Staphylococcus epidermidis. At the same time, there was no significant difference in the water. 
HEALTH EXAMINATION AND EDUCATION ON THE USE OF CHOLESTEROL, URIC ACID, AND BLOOD SUGAR MEDICINE FOR THE COMMUNITY OF SUNGAI BAWANG VILLAGE, MUARA BADAK DISTRICT, KUTAI KARTANEGARA Adhe Septa Ryant Agus; Muh. Taufiqurrahman; Awan, Kevin Imanuel; Gilbert Luhat, Martin
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 8 No. 3 (2024): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v8i3.2024.441-450

Abstract

Degenerative diseases that many people suffer from, including heart disease, stroke, hypertension, diabetes mellitus, cancer, and chronic kidney failure, have increased. In demographic data referring to the 2018 Riskesdas, for example, strokes increased to 10,9% from the previous 7%, and diabetes mellitus increased from 6.9% to 8.5% in 2018. Hypertension experienced the highest increase among diseases, from 25.8% to 34.1%. Management of degenerative diseases is through implementing community service activities carried out by lectures from the Study Program of Pharmacy undergraduate at STIKES Dirgahayu Samarinda to implement the tridharma obligations of higher education. The activity was held on Saturday, November 18, 2023, at Lamin Adat Sungai Bawang Village, Muara Badak District, Kutai Kartanegara. This activity aimed to conduct health checks for the community, from children to adults, and health education, especially controlling non-communicable diseases. The method used was education, free examination, and treatment for the community which consists of laboratory examinations, health consultations, pharmaceutical services, and health education, as well as evaluation when the activites have been completed. Based on the activities that have been carried out, it was known that one hundred and five residents came for an examination, then from screening for blood sugar, cholesterol, and uric acid tests, forty-seven people exceeded normal parameters, while ninety-eight received drug therapy.
Uji Stabilitas Formula Krim Tabir Surya Ekstrak Umbi Bawang Dayak (Eleutherine americana L. Merr.) Islamudin Ahmad; Adhe Septa Ryant Agus
Journal of Tropical Pharmacy and Chemistry Vol. 2 No. 3 (2013): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v2i3.62

Abstract

Has conducted research on formulation and stability of sunscreen cream onion bulb extract dayak ( Eleutherine Americana L. Merr . ) . From the empirical data for the onions dayak has been used as an anti- cancer prevention and treatment by people of Borneo so it needs to be further investigated to obtain the data laboratory to support the empirical data . Several classes of secondary metabolites found in the bulbs of onions dayak alkaloids , glycosides , flavonoids , phenolics , steroids and tannins . The study was conducted as the basis for the formulation of sunscreen preparations aimed at the prevention of skin cancer . The study was conducted with bulb onions dayak extraction using Soxhlet method with solvent n - hexane , ethyl acetate , n - butanol , and ethanol as the active ingredient of the formula of making preparations . Tests conducted on formulations A and B with the concentration of garlic bulb extract dayak by 0.1% , consisting of physical stability test ( organoleptic , homogeneity ) and chemical ( pH and dosage ) in order to obtain a stable dosage formula . The test results obtained on the organoleptic test was no change in the observations made on each preparation before and after storage at room temperature on day - 7 , -14 , and -21 . Then the homogeneity test of the hedonic test results at 95% confidence level ( SNI 01-2346-2006 ) , concluded that the homogeneity of the preparation in all formulas produced in the category of smooth . Further testing on the pH stability and pH 5.5 to 8.0 to be produced that Formula A and Formula B to pH 7.0 to 7.7 with various concentrations of the extract , after 21 days of storage , inferred pH remains stable and safe dosage for used ( SNI 16-4399-1996 ) as formula sunscreen preparations made from onion bulb extract dayak . Key words : bulb onions dayak, sunscreen, formulas, test stability, skin cancer ABSTRAK Telah dilakukan penelitian mengenai formulasi dan stabilitas krim tabir surya ekstrak umbi bawang dayak (Eleutherine Americana L. Merr.). Dari data empirik selama ini bawang dayak telah digunakan sebagai pencegah dan pengobatan anti kanker oleh masyarakat Kalimantan sehingga perlu diteliti lebih lanjut untuk mendapatkan data laboratorik untuk mendukung data empirik tersebut. Beberapa golongan metabolit sekunder yang terdapat pada umbi bawang dayak yakni alkaloid, glikosida, flavonoid, fenolik, steroid dan zat tannin. Penelitian tersebut dilakukan sebagai dasar pembuatan formulasi sediaan krim tabir surya yang ditujukan untuk pencegahan terjadinya kanker kulit. Penelitian dilakukan dengan ekstraksi umbi bawang dayak menggunakan metode soxhlet dengan pelarut n-heksan, etil asetat, n-butanol, dan etanol sebagai bahan aktif dari pembuatan formula sediaan. Pengujian dilakukan terhadap formulasi A dan B dengan konsentrasi ekstrak umbi bawang dayak sebesar 0,1%, terdiri dari uji stabilitas fisik (organoleptis, homogenitas) dan kimia (pH dan sediaan) agar diperoleh formula sediaan yang stabil. Hasil pengujian yang diperoleh adalah pada uji organoleptis tidak ada perubahan pada pengamatan yang dilakukan terhadap masing-masing sediaan sebelum dan setelah penyimpanan pada suhu kamar pada hari ke-7, -14, dan -21. Kemudian pada uji homogenitas dari hasil uji hedonik pada tingkat kepercayaan 95% (SNI 01-2346-2006), disimpulkan bahwa homogenitas sediaan pada semua formula yang dihasilkan masuk dalam kategori halus. Selanjutnya pada stabilitas pH dilakukan pengujian dan dihasilkan bahwa pH 5,5-8,0 untuk Formula A dan pH 7,0-7,7 untuk Formula B dengan berbagai konsentrasi ekstrak, setelah penyimpanan 21 hari, disimpulkan pH sediaan masih stabil dan aman untuk digunakan (SNI 16-4399-1996) sebagai formula sediaan tabir surya berbahan ekstrak umbi bawang dayak. Kata kunci: umbi bawang dayak, tabir surya, formula, uji stabilitas, kanker kulit
Antidepressant Activity Study of Keruing (Dipterocarpus grandiflorus) Oleoresin Candle Aromatherapy on Male Mice (Mus musculus) Balb/C Strain Agus, Adhe Septa Ryant; Butar-Butar, Maria Elvina Tresia; Fernandes, Andrian; Maharani, Rizki; Awan, Kevin Imanuel; Luhat, Martin Gilbert
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 3 No 2 (2024): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v3i2.24665

Abstract

Depression represents a manifestation of prolonged stress, which, if left untreated, may lead to severe mental disorders. For depression treatment therapy, it can be carried out based on evidence-based treatment for depression and anxiety. Aromatherapy candles can be used as a non-pharmacological medium for depression therapy, where keruing has active compounds are phthalic acid di(3-methoxybenzyl) ester and phthalic acid, 5-ethyl-1,3-dioxan-5-yl octyl ester, causing keruing oleoresin to have a distinctive fragrance. This study aims to evaluate the pharmacological potential of keruing as an antidepressant for non-pharmacological therapy. Aromatherapy candles were formulated with keruing oleoresin at concentrations of 0%, 2.5%, 5%, 7.5%, and 10%, followed by testing their antidepressant activity using the Conditioned Place Preference (CPP) method. The results of the Paired T-test for groups F0, F2, and F4 or formulas containing 0%, 5%, and 10% of keruing oleoresin have a significant effect (sig. values <0.05) between pre and post-test being given aromatherapy and induction. In the One-way ANOVA test, between their groups, it can be seen there was no significant difference in test activity, namely for the pre-treatment test (sig. 0.445 > 0.05) and for the post-treatment test (sig. 0.065 > 0.05). Results indicated that while the candles met physical quality standards outlined by the Indonesian National Standard (SNI), no significant antidepressant effects were observed in mice. Further refinement in methodology, including the concentration of active compounds and delivery methods, is recommended to enhance the pharmacological potential of keruing oleoresin.
Optimization of Cream Formulation with Borneo Tallow Nut, Almond Oil, and Olive Oil Using the Simplex Lattice Design Method Butar-Butar, Maria Elvina Tresia; Taufiqurrahman, Muh; Agus, Adhe Septa Ryant; Sari, Dwi Retno; Selvina, Selvina; Tokan, Santa Eufrasia Carolin
Sciences of Pharmacy Volume 3 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0304260

Abstract

Dry skin, a common dermatological issue affecting individuals across all age groups, often disrupts the skin's protective barrier, leading to discomfort and increased sensitivity. Addressing this condition involves the use of moisturizers, which play a vital role in restoring skin hydration. In this study, a cream preparation was successfully developed using vegetable oils, including Borneo Tallow Nut, Almond Oil, and Olive Oil. The cream formula was optimized using the Design-Expert software with the Simplex Lattice Design (SLD) method to evaluate the impact of different concentrations of these oils on the cream's pH, viscosity, spreadability, and adhesion. The results demonstrated that the cream exhibited excellent thermo-physical stability, with optimum values of Borneo Tallow Nut at 1.349% w/w, Almond Oil at 3.598% w/w, and Olive Oil at 4.051% w/w. The cream achieved a pH value of 5.702, viscosity of 16.851 Cp, spreadability of 8.147 cm, and adhesion of 63.682 s, with a desirability score of 0.718. This research confirms that Borneo Tallow Nut, Olive Oil, and Almond Oil have significant potential as excipients in cream formulations.
ANALISIS RHODAMIN B PADA LIPSTIK IMPOR YANG BEREDAR DI PASAR PAGI KOTA SAMARINDA DENGAN SPEKTROFOTOMETRI UV-VISIBLE Pangestika, Ruth Gratia Dwi; Leswana, Nurillahi Febria; Agus, Adhe Septa Ryant
Jurnal Ilmiah Manuntung Vol 11 No 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.848

Abstract

Rhodamine B is commonly used as a dye for textiles (silk, wool, cotton), paint, paper, and clothing. Prolonged ingestion or exposure may irritate the respiratory tract, eyes, and skin, cause nausea and vomiting, and potentially lead to liver cancer or even cell death. This study aims to identify the presence of Rhodamine B dye in imported lipsticks sold at Pasar Pagi, Samarinda City. The research involved both qualitative and quantitative analyses. The qualitative test was conducted using Thin Layer Chromatography (TLC) with an eluent mixture of ethyl acetate : ethanol : ammonia (11:2:1), while the quantitative test employed UV-Vis spectrophotometry. The qualitative results using TLC showed that sample H had an Rf value of 0.529 cm, which closely resembled the standard Rhodamine B Rf value of 0.623 cm. The quantitative analysis revealed Rhodamine B concentrations in sample A (0.12%), sample B (0.19%), sample C (0.16%), sample F (0.20%), sample G (0.16%), sample H (0.37%), sample I (0.27%), and sample J (0.03%). The validity test indicated a linear result. The precision test showed Relative Standard Deviation (RSD) values of 1.7% for samples G, H, and I. The accuracy test yielded recovery percentages in sample G of 92% (2 ppm), 99% (4 ppm), and 86% (6 ppm); and in sample H of 88% (2 ppm), 98% (4 ppm), and 94% (6 ppm).
EVALUASI PERESEPAN FORMULARIUM DI APOTEK RAWAT JALAN RSUD TAMAN HUSADA BONTANG PERIODE APRIL - JUNI TAHUN 2023 Muhammad Evan; Adhe Septa Ryant Agus; Raymon Simanullang
Journal of Innovation Research and Knowledge Vol. 5 No. 2: Juli 2025
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hospitals must follow the National Formulary when prescribing drugs. According to the National Formulary, the percentage of drug prescriptions in hospitals is at least 80%, according to the standard indicator of health service quality number 30 of 2022 concerning hospital prescriptions. One of the class B hospitals in East Kalimantan Province, Taman Husada Bontang General Hospital treats patients with National Health Insurance (JKN), whose population continues to grow. The purpose of this study was to assess the suitability of Bontang Regional Hospital to prescribe drugs in 2023 according to the National Formulary. Retrospective data collection was used in an observational study design. Based on the inclusion and exclusion criteria, the study sample consisted of all prescription sheets for outpatients at Bontang Regional Hospital from April to June 2023. Prescription forms, drug content, dosage strength, and dosage form are indicators of suitability for prescribing. By comparing the number of drug prescriptions written according to the National Formulary with the total number of prescriptions, the percentage of suitability was calculated. According to the National Formulary, 98.23% of drug items matched, and 99.76% of prescription sheets also matched. Bontang Regional Hospital's prescription is not 100% in accordance with the National Formulary, but based on drug items and prescriptions, it has exceeded the standard indicators of drug prescriptions in hospitals (more than 80%).
Pengolahan Bumbu Dapur yang Berkhasiat, Aman dan Bermutu sebagai upaya Peningkatan Imunitas Tubuh melalui Pembuatan Minuman Herbal Taufiqurrahman, Muh.; Agus, Adhe Septa Ryant
Jurnal Pengabdian Pada Masyarakat Vol 10 No 3 (2025): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v10i3.1340

Abstract

Penguatan imunitas tubuh masyarakat dapat dilakukan melalui pemanfaatan bahan alam, khususnya bumbu dapur yang memiliki khasiat sebagai minuman herbal. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan dan keterampilan anggota Persatuan Dharma Wanita Provinsi Kalimantan Timur dalam mengolah tanaman obat menjadi minuman kesehatan yang aman, bermanfaat, dan mudah diaplikasikan dalam kehidupan sehari-hari. Metode pelaksanaan meliputi penyuluhan mengenai kandungan bahan aktif dan manfaat rempah-rempah, praktik langsung pembuatan minuman herbal, serta evaluasi menggunakan angket dan kuis singkat untuk menilai pemahaman peserta. Materi yang disampaikan difokuskan pada prinsip keamanan, higienitas, serta efektivitas penggunaan rempah-rempah seperti jahe, kunyit, dan belimbing dalam pembuatan minuman kesehatan. Hasil kegiatan menunjukkan adanya peningkatan signifikan pada tingkat pemahaman peserta mengenai manfaat dan cara pengolahan herbal sesuai kaidah keamanan pangan. Antusiasme peserta terlihat melalui keaktifan dalam diskusi, keberanian mengajukan pertanyaan, serta ketekunan saat praktik pembuatan minuman herbal. Selain itu, peserta menyatakan minat yang tinggi untuk menerapkan pengetahuan yang diperoleh di rumah, baik untuk konsumsi keluarga maupun peluang usaha kecil berbasis produk jamu dan minuman herbal. Temuan ini menunjukkan bahwa pelatihan berbasis praktik dapat menjadi sarana efektif dalam memperluas wawasan dan kemandirian masyarakat dalam menjaga kesehatan melalui pemanfaatan bahan alam. Keberhasilan kegiatan ini diharapkan dapat mendorong pelaksanaan program serupa secara berkelanjutan guna mendukung gaya hidup sehat berbasis kearifan lokal. Strengthening community immunity can be achieved through the utilization of natural ingredients, particularly kitchen spices that have properties beneficial as herbal drinks. This community service program aimed to enhance the knowledge and skills of the members of the Dharma Wanita Association of East Kalimantan Province in processing medicinal plants into safe, beneficial, and practical health beverages. The implementation methods included educational sessions on the active compounds and health benefits of spices, hands-on herbal drink preparation, and evaluation using questionnaires and short quizzes to assess participants’ understanding. The material focused on food safety principles, hygiene, and the effectiveness of using spices such as ginger, turmeric, and starfruit in making health drinks. The results showed a significant increase in participants’ understanding of the benefits and proper processing of herbal ingredients in accordance with safety standards. Participants demonstrated high enthusiasm through active discussions, eagerness to ask questions, and diligence during the practical herbal drink preparation. Furthermore, participants expressed strong interest in applying the knowledge gained at home, both for family consumption and as potential small-scale business opportunities based on herbal drinks and traditional jamu products. These findings indicate that practice-based training can serve as an effective medium to broaden public awareness and independence in maintaining health through the use of natural ingredients. The success of this activity is expected to encourage the continuous implementation of similar programs to promote a healthy lifestyle grounded in local wisdom.