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All Journal Andalas obstetrics and gynecology journal Indonesian Journal of Perinatology
Kade Yudi Saspriyana
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Risk factors and characteristics of cervical cancer patients under 40 years old at Prof Dr I.G.N.G. Ngoerah Hospital Denpasar, Bali from January until December 2022 I Nyoman Gede Budiana; I Nyoman Bayu Mahendra; I Gde Sastra Winata; Kade Yudi Saspriyana; Kevin Agastya Duarsa; Pande Made Suwanpramana; Rayvany Uil; Dewi, Putu Pradnya Paramitha; Made Yudha Ganesa Wikantyas Widia; Eric Gradiyanto Ongko; I Gede Indra Kumara; Charles Richard Thene; Johan Qalaba; Made Ayu Prabawaty Indraswari; Ida Bagus Arjuna; Putu Harrista Indra Pramana; Ernest T. B. Sianturi
Indonesian Journal of Perinatology Vol. 4 No. 2 (2023): Available online : 1 December 2023
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i2.33

Abstract

Background: Cervical cancer is the main cause of death for women worldwide. 500.000 new cases and 250.000 deaths are reported each year. In Indonesia, women as young as 25 are being diagnosed with this disease. The study will be conducted at Prof.Dr.I.G.N.G Ngoerah Hospital from January to December 2022 to analyze cervical cancer patients under 40. This study aimed to see the profile and the distribution of 40 year-old women with cervical cancer at our hospital. Methods: This descriptive study was conducted using medical records that were centered around female patients who were below 40 years of age and had been diagnosed with cervical cancer in Prof.Dr.I.G.N.G Ngoerah hospital in January - December 2022. Purposive sampling was done, and the samples were selected according to the inclusion criteria. The resulting data was presented in a table format. Results: Fifty-one cervical cancer patients aged under 40 years were included, with most of the age group being 30 – 39 years (88.2%). Twenty-eight patients (54.9%) were in the two-to-three parity group. The most dominant stage of cervical cancer is stage IIIB, with a total of 20 people (39.2%). Non-keratinizing squamous cell carcinoma (NKSCC) was the most common histopathological appearance (64.7%).  Conclusions: The study found that cervical cancer commonly affects those between 30-39 years old, particularly in the form of NKSCC. Many patients are diagnosed in advanced stages of the disease. Early screening, education, and vaccination programs are crucial in preventing cervical cancer.
Retrograde Hysterectomy Approaches in Difficult Gynaecology Surgery I Gde Sastra Winata; Ongko, Eric Gradiyanto; I Nyoman Gede Budiana; I Nyoman Bayu Mahendra; Kade Yudi Saspriyana; Pande Kadek Aditya Prayudi; Arlando Martino Anapaku; Florencia
Indonesian Journal of Perinatology Vol. 6 No. 1 (2025): (Available online: 1 June 2025)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v6i1.70

Abstract

Hysterectomy remains one of the most frequently performed gynecological surgeries worldwide. While extra-fascial hysterectomy is the standard abdominal approach, complex cases involving large fibroids, severe endometriosis, adhesions, or malignancy often require alternative techniques such as the Aldridge method or retrograde hysterectomy. These challenging situations are associated with distorted pelvic anatomy, fibrosis, and adhesions, increasing the risk of complications, including injury to adjacent organs. This article reviews strategies and operative steps in managing complex abdominal hysterectomies, with emphasis on retrograde hysterectomy as a valuable approach when the cervicovaginal junction cannot be clearly identified or when extensive adhesions are present. The surgical technique is described step by step, supported by imaging and intraoperative findings, and highlights methods such as hydrodissection and careful dissection around critical structures to minimize morbidity. Preoperative imaging, intraoperative decision-making, and technical modifications are emphasized as key factors for optimizing patient outcomes. Although this study provides a detailed description of techniques under challenging hysterectomies, its limitation lies in the reliance on schematic illustrations rather than comprehensive intraoperative photographic documentation.
Pengaruh Pemberian Magnesium Sulfat (MgSO4) Terhadap Kadar Nitric Oxide dan Prostacyclin pada Preeklampsia Pangkahila, Evert; Kade Yudi Saspriyana; Clara Amanda; Winty Septiani
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.1-15.2025

Abstract

Introduction :  Preeclampsia is a pregnancy-related syndrome with significant maternal and neonatal risks, affecting 4.6% of pregnancies globally. Its pathophysiology, linked to an imbalance between prostacyclin (a vasodilator) and thromboxane (a vasoconstrictor), remains poorly understood. Magnesium sulfate (MgSO4) is widely used for seizure prophylaxis in preeclampsia, but its effect on nitric oxide (NO) and prostacyclin levels is still debated. Methods: This quasi-experimental study included 30 pregnant women diagnosed with severe preeclampsia. Baseline serum levels of NO and prostacyclin were measured before MgSO4 administration and re-evaluated after 24 hours of treatment. Changes in biomarker levels were assessed using paired t-tests, with a significance threshold of p < 0.05. Results: The mean NO level increased from 35.2 ± 5.6 µmol/L before treatment to 49.8 ± 6.3 µmol/L after MgSO4 administration, showing a statistically significant difference (p < 0.001). Similarly, prostacyclin levels rose from a baseline of 42.1 ± 4.8 pg/mL to 58.7 ± 5.2 pg/mL post-treatment (p < 0.001). These findings suggest a robust enhancement of vasodilatory activity, supporting the role of MgSO4 in improving vascular endothelial function. Conclusion: MgSO4 administration significantly increases NO and prostacyclin levels, demonstrating its efficacy in reducing vascular resistance in preeclamptic pregnancies. These results reinforce its clinical utility, offering a mechanistic insight into its vasodilatory and anti-convulsive properties. Keywords: Preeclampsia, magnesium sulfate, nitric oxide, prostacyclin, vascular biomarkers
Co-Authors Arlando Martino Anapaku Charles Richard Thene Clara Amanda Dewi, Putu Pradnya Paramitha Eric Gradiyanto Ongko Ernest T. B. Sianturi FLORENCIA I Gde Sastra Winata I Gede Indra Kumara I Nyoman Gede Budiana Ida Bagus Arjuna Johan Qalaba Kevin Agastya Duarsa Made Ayu Prabawaty Indraswari Made Yudha Ganesa Wikantyas Widia Nyoman Bayu Mahendra Ongko, Eric Gradiyanto Pande Kadek Aditya Prayudi Pande Made Suwanpramana Pangkahila, Evert Putu Harrista Indra Pramana Rayvany Uil Winty Septiani