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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN BALI MEDICAL JOURNAL (BMJ) Medicina E-Jurnal Medika Udayana Indonesian Journal of Cancer The Indonesian Biomedical Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Batoboh : Jurnal Pengabdian Pada Masyarakat ISM (Intisari Sains Medis) : Jurnal Kedokteran Journal of Community Development Indonesian Journal of Perinatology Perwira Journal of Science and Engineering (PJSE) Indonesian Journal of Cancer Perwira Journal of Community Development (PJCD)

Nyoman Bayu Mahendra

Gynecologic Oncology Division, Obstetrics And Gynecology, Faculty Of Medicine, Universitas Udayana, Sanglah General Hospital, Bali, Indonesia

Author-ID : 241649

Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Mixed Adeno and Neuroendocrine Carcinoma of The Ovary: Case Report MANNA, JOHANA SENSY LENI; SASPRIYANA, KADE YUDI; MAHENDRA, I NYOMAN BAYU; SUWIYOGA, KETUT; MAKER, LUH PUTU IIN INDRAYANI
Indonesian Journal of Cancer Vol 11, No 3 (2017): July - September 2017
Publisher : Indonesian Journal of Cancer

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Reporting two cases of mixed adenocarcinoma and neuroendocrine carcinoma of the ovary. A case report two cases of an ovarian cyst suspect malignancy after complete surgical staging in woman aged 39 year old and 72 year old. By this case report, we want to know prognosis of the malignancy. Mixed adenocarcinoma and neuroendocrine carcinoma of the ovary of the first case arised from mature cystic teratoma, and second case as metastatic process from gastrointestinal tract. Mixed adenocarcinoma and neuroendocrine carcinoma is rare hystologic type of ovarian cancer. Need further exploration to know the survival of this hystologic type.ABSTRAKArtikel ini melaporkan dua kasus, yaitu mixed adenocarcinoma dan neuroendocrine carcinoma ovarium, dua kasus kista ovarium curiga ganas pada pasien berusia 39 tahun dan 72 tahun. Terhadap kedua pasien dilakukan komplit surgical staging. Melalui laporan kasus ini, diharapkan bisa diketahui prognosis kasus. Mixed adenocarcinoma dan neuroendocrine carcinoma ovarium pada kasus pertama timbul dari teratoma matur kistik, sedangkan kasus kedua merupakan penyebaran dari traktus digestivus. Mixed adenocarcinoma dan neuroendocrine carcinoma merupakan tipe histologi kanker ovarium yang jarang. Ia membutuhkan eksplorasi lebih lanjut untuk mengetahui survival dari tipe histologi ini.

Management of Pseudomyxoma Peritonei Syndrome during Pregnancy Aditanzil, Hanny; Mahendra, Bayu; Suwiyoga, Ketut
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 3, July 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objectives: To improve skill in making a diagnosis and management of pseudomyxoma peritoneum originating borderline mucinous ovarian tumor during pregnancy. Methods: Case report. Conclusion: Diagnosis of pseudomyxoma peritoneum during pregnancy is difficult before surgery. Management is based on grade of malignancy and gestational age of pregnancy. [Indones J Obstet Gynecol 2013; 1-3: 161-5] Keywords: mucinous tumor, pregnancy, pseudomyxoma peritoneum

The Characteristics of Cervical Cancer Patients Who Underwent a Radical Hysterectomy at Sanglah Hospital Denpasar in 2015 Mahendra, I Nyoman Bayu
BALI MEDICAL JOURNAL Vol 5 No 2 (2016)
Publisher : BALI MEDICAL JOURNAL

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Background: Cervical cancer is the most common gynecologic cancer in women. It is the main cause of cancer-related death in women in developing countries. Cervical cancer in Indonesia is the second most cancer affecting Indonesian women and the prevalence is relatively stable in the last 30 years. Cervical cancer was closely related to the histologic type of itself. A squamous cell carcinoma has a specific route of local spreading and a lymphatic route. The sample of this study are cervical cancer patients who underwent a radical hysterectomy from January 1 to December 31, 2015 in Sanglah Hospital Denpasar, Bali. The aim of this study is to discover the characteristics of the patients by age, parity, education level, marital status, sexual activity, the first symptoms and the early screening done, and the clinical staging. Methods: This descriptive study involved 20 patients in Sanglah Hospital Denpasar who had a radical hysterectomy from January 1 until December 31, 2015. The characteristics are gathered from the patients’ medical record. Results: The most cases done radical hysterectomy between 41-45 years old which proportion was 40%, the most parity was parity 2 (60%), elementary school was the most education level (35%), all of the samples only married once and sexually active, the most first symptom was vaginal bleeding (55%), only 10% had pap smear as early detection, and the most clinical stage was stage IIB (50%).

LOW MOLECULAR MASS POLYPEPTIDE AND TRANSPORTER ANTIGEN PEPTIDE GENES POLYMORPHISM AS THE RISK FACTORS OF CERVICAL CANCER WHICH CAUSED BY HUMAN PAPILLOMAVIRUS TYPE-16 INFECTION IN BALI Mahendra, I Nyoman Bayu
BALI MEDICAL JOURNAL Vol 4 No 3 (2015)
Publisher : BALI MEDICAL JOURNAL

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Background: Until recently, cervical cancer is one of the major problem in women’s health issue related to its high incidence and mortality rate. The etiology of cervical cancer is the high risk oncogenic group of Human Papillomavirus (HPV), especially HPV-16 and 18 and its phylogenies. Meanwhile in Bali, more than 50% of infection are caused by HPV-16 infection. The main objective of this study was to investigate the role of LMP-2, LMP-7, TAP-1 and TAP-2 gene polymorphism as the risk factor in the cervical cancer carcinogenesis that is caused by HPV-16 infection. Method: A nested non-paired case-control study was conducted at Obstetric and Gynecologic Department Sanglah General Hospital, Bali Indonesia from March 1 until August 31, 2013. Laboratory testing was carried out at Laboratory of Histopathology Leiden University Medical Centre, Netherlands,. Results: A total of 40 samples were collected, consist of 20epithelial cervical cancer patients with positive HPV-16 infection as the case group and 20 non-cervical cancer patients with positive HPV-16 infection as the control group. Women infected by HPV-16 with LMP-7 gene polymorphism had a higher risk (OR=7.36, CI 95%=1.38-40.55, p=0.013) to be diagnosed with cervical cancer. Balinese women who were infected by HPV-16 with TAP-2 gene polymorphism had a higher risk (OR= 9.33, CI 95%=2.18-39.96, p=0.001) to be diagnosed with cervical cancer. Meanwhile, Balinese women who were infected by HPV-16 with LMP-7 and TAP-2 genes polymorphism had a higher risk (OR=12.67, CI 95%=1.40-114.42, p=0.020) to be diagnosed with cervical cancer. As the result, it was shown that both of this gene polymorphism was working synergistically. Conclusion: TAP-2 and LMP-7 genes polymorphism play a role in the carcinogenesis mechanism of cervical cancer that is caused by HPV-16 infection in Bali. Meanwhile, LMP-2 and TAP-1 genes polymorphism were not found to play a role in the immunology pathway of cervical cancer that is caused by HPV-16 infection.

HUMAN PAPILLOMA VIRUS VACCINE Bayu Mahendra, Nyoman
Medicina Vol 43 No 2 (2012): Mei 2012
Publisher : Medicina

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Cervical cancer is the most common gynecologic cancer in womer, and it has the highest cancer-related deaths in developing country. The incidences kept increasing every year, associated with delay on diagnosis, limited human resources, knowledge, education, facilities, and influence of socioeconomicculture. Currently, infection of oncogenic group high risk human papillomavirus (HPV), especially HPV-16 and HPV-18 has been widely accepted as the cause of cervical cancer. The finding of HPV vaccine brings new hope to all of us. With primary prevention, the incidence can be brought down. Later on, every women can be freed from in cervical cancer

KARAKTERISTIK PERSALINAN LETAK SUNGSANG DI RSUP SANGLAH DENPASAR RENTANG WAKTU 1 JANUARI-31 DESEMBER 2018 Ni Kadek Ari Chintya Vedantari; I Nyoman Gede Budiana; Jaqueline Sudiman; I Nyoman Bayu Mahendra
E-Jurnal Medika Udayana Vol 10 No 1 (2021): Vol 10 No 01(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i1.P15

ABSTRAK Posisi sungsang yakni suatu kondisi dimana posisi janin memanjang dalam rahim dimana bagian kepala janin berada pada fundus uteri, sedangkan posisi bokong berada di bawah kavum uteri. Terdapat beberapa faktor yang terkait dengan peningkatan risiko letak sungsang antara lain : umur ibu, paritas, umur gestasional, berat bayi lahir, riwayat seksio sesaria, kehadiran cacat bawaan dan jenis kelamin bayi. Angka kesakitan begitu juga angka kematian bayi pada letak sungsang lebih tinggi daripada letak kepala, begitu juga dengan morbiditas ibu. Penelitian ini bertujuan untuk mengetahui karakteristik persalinan letak sungsang di Rumah Sakit Umum Pusat Sanglah Denpasar Bali tahun 2018. Metode penelitian adalah deskriptif menggunakan studi cross sectional. Sampel dipilih dari populasi melalui kriteria inklusi dan eksklusi. Software SPSS versi 17 digunakan untuk menganalisis data penelitian agar dapat memperoleh karakteristik berdasarkan umur ibu, paritas, umur gestasional, jenis persalinan, skor APGAR, berat badan bayi lahir dan jenis kelamin bayi. Penelitian menunjukkan persalinan letak sungsang di RSUP Sanglah Denpasar Bali rentang waktu 1 Januari-31 Desember 2018 terbanyak terjadi pada kelompok tanpa risiko dengan rentang umur (20-35 tahun) sebesar 69,2% dengan paritas terbanyak yaitu multipara (69,2%). Umur gestasional yang terbanyak adalah prematur sebesar 64,1 % dengan persalinan seksio sesaria sebagai persalinan terbanyak yang ditemukan yaitu 53,8%. Mayoritas bayi dengan persalinan letak sungsang memiliki skor APGAR normal (82,1%). Selain itu, bayi yang dilahirkan dengan berat badan lahir rendah didapatkan dengan hasil terbanyak (61,5%) dengan didominasi oleh jenis kelamin bayi perempuan (56,4%). Kata Kunci: Persalinan letak sungsang, Karakteristik

KARAKTERISTIK PASIEN KANKER SERVIKS DI RSUP SANGLAH DENPASAR PERIODE 1 JANUARI – 31 DESEMBER 2017 Ni Putu Pramana Saras Utami; I Nyoman Bayu Mahendra; Endang Sri Widiyanti; Jaqueline Sudiman
E-Jurnal Medika Udayana Vol 9 No 4 (2020): Vol 9 No 04(2020): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Cervical cancer is one of the most serious malignancies because of its high incidence and transmission rate, which is around 270.000 female mortality cases occured in 2015 because of cervical cancer and 85% occured in developing countries such as Indonesia. The aim is to knowing the characteristics of cervical cancer patient at Sanglah Denpasar General Hospital during period 1st January – 31st December 2017. This research is descriptive and cross sectional. Sampling technique is total sampling where the research data comes from secondary data which is medical record of cervical cancer patient at Sanglah Denpasar General Hospital during period 1st January – 31st December 2017. The highest incidence of cervical cancer was found in group 41-50 years old as many as 23 people (32.9%), had the highest education level at elementary school as many as 34 people (48.6%), worked as housewife as many as 32 people (45.7%), majority did not have history of smoking as many as 68 people (97.1%) and did not have history of using oral contraceptive as many as 64 people (91.4%), had the age of first marriage in group 20-30 years old as many as 33 people (47.1%), have been married once as many as 67 people (95.7%), have three parity as many as 23 people (32.9%), had squamous cell carcinoma non keratinizing histopathology biopsy type as many as 47 people (67.1%), and first diagnosed with cervical cancer in stadium III B as many as 31 people (44.3%). Keywords : cervical cancer, characteristic, age, education, occupation, smoking history, oral contraceptive use history, age of first marriage, number of marriage, number of parity, histopathology biopsy result, clinical stadium

KUALITAS OOSIT, EMBRIO, DAN KEHAMILAN PASIEN ENDOMETRIOSIS STADIUM III-IV DAN PASIEN DENGAN INFERTILITAS TUBA FALOPI YANG MENGIKUTI PROGRAM BAYI TABUNG DI RUMAH SAKIT BROS TAHUN 2015-2019 Tjokorda Istri Putri Adhyasari Wulandari; I Nyoman Bayu Mahendra; IB Fajar Manuaba; IB Putra Adnyana; Jaqueline Sudiman
E-Jurnal Medika Udayana Vol 10 No 3 (2021): Vol 10 No 03(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i3.P07

ABSTRAK Endometriosis adalah kondisi dimana terdapat kelenjar endometrium dan lesi seperti stroma di luar kavum uteri. Endometriosis dapat menimbulkan infertilitas serta mempengaruhi kualitas oosit, embrio, dan kehamilan pada saat menjalani program bayi tabung. Penelitian ini bertujuan untuk mengetahui perbedaan kualitas oosit, embrio dan kehamilan antara pasien endometriosis stadium III-IV (sedang-berat) dengan pasien dengan Infertilitas Tuba Falopi (ITF) saat menjalani program bayi tabung. Penelitian ini merupakan penelitian analitik observasional dengan desain kasus-kontrol. Subjek penelitian yaitu 64 sampel kelompok penderita endometriosis stadium III-IV sebagai kelompok kasus dan 100 sampel kelompok ITF sebagai kelompok kontrol. Pengambilan sampel dilakukan menggunakan teknik purposive sampling.Data penelitian diperoleh dari data hasil laboratorium klinik Royal IVF Bali Royal Hospital (BROS). Hasil penelitian menunjukkan adanya perbedaan signifikan pada kualitas hormon, yaitu hormon basal Follicle Stimulating Hormone (FSH) (5,76+ 2,5 berbanding 5,68 +1,7; p<0,05) dan kadar estradiol akhir (1798,00+ 760,71 berbanding 2195,00 + 1512,9; p<0,05). Perbedaan yang signifikan ditemukan pada kualitas oosit, yaitu pada parameter jumlah folikel (p=0,02), dan jumlah oosit yang matang (p=0,04). Perbedaan signifikan didapatkanpada kualitas embrio yaitu embrio grade 1 pada hari ke-3 (p=0,04). Tidak ditemukan adanya perbedaan dalam hal kualitas kehamilan. Penelitian ini menyimpulkan bahwa terdapat perbedaan kualitas hormonal, oosit, dan embrio antara kelompok endometriosis stadium III-IV dan kelompok ITF yang menjalani program bayi tabung, akan tetapi kualitas kehamilan pada kedua kelompok tidak berbeda signifikan. Penelitian cohort prospektif dengan data primer selanjutnya diperlukan untuk mengurangi bias informasi maupun bias seleksi kelompok. Kata kunci: Endometriosis stadium III-IV, kualitas oosit, kualitas embrio, kualitas kehamilan, Infertilitas Tuba Falopi (ITF)

PROFIL PASIEN YANG MENJALANI PROGRAM SEE AND TREAT DI PUSKESMAS MENGWI I TAHUN 2017-2018 Putu Srinata Dampati; I Nyoman Gede Budiana; I Nyoman Bayu Mahendra; I. B. G. Fajar Manuaba
E-Jurnal Medika Udayana Vol 10 No 12 (2021): Vol 10 No 12(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i12.P09

Cervical cancer is one of the high incidence cancer in the world including Indonesia. The mortality of this cancer is also high. In order to decrease number of incidence and mortality rate, prevention must be done. Cervical cancer prevention can be conducted through early detection/screening of precancer lesion. See and treat is one of the screening method to prevent cervical cancer development. This method uses Visual Inspection with Acetic Acid (VIA) for screening and cryotherapy as a treatment if VIA test show positive result. The goal of this study is to determine profile of patients who undergo see and treat programme in Puskesmas Mengwi I in 2017-2018. This study is a descriptive cross sectional study using secondary data obtained from patient’s medical record who undergo see and treat programme in Puskesmas Mengwi I in 2017-2018. Sample taken using total sampling technique. There are 155 patients (1.39%) which obtained from this study from 11,146 total female population in Puskesmas Mengwi I working area, about 84 patients (54.2%) are > 35 years old, 142 patients (91.6%) first married at the age ? 20, 94 patients (60.6%) have graduated college, 105 patients (67.7%) are currently working, 76 patients (49.0%) using IUD, 43 patients (27.7%) had no gynecological complain, 91 patients (58.7%) have < 3 children, 10 patients (6.5%) show positive VIA result, and all of the VIA positive patient (100%) treated using cryotherapy. Keywords : see and treat, VIA, cryotherapy.

EVALUASI SERUM KREATININ DAN BLOOD UREA NITROGEN PASIEN KANKER SERVIKS YANG MENJALANI KEMOTERAPI PAKLITAKSEL-KARBOPLATIN DI RSUP SANGLAH DENPASAR TAHUN 2018 Ni Komang Vina Indriyani; I Nyoman Bayu Mahendra; Ida Bagus Gede Fajar Manuaba; I Gede Ngurah Harry Wijaya Surya
E-Jurnal Medika Udayana Vol 10 No 2 (2021): Vol 10 No 02(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/.MU.2021.V10.i2.P07

Kanker serviks ialah keganasan kedua terbanyak di Indonesia. Salah satu penatalaksanaannya yaitu kemoterapi. Tujuan penelitian ini ialah mengetahui fungsi ginjal pasien kanker serviks setelah dilakukan kemoterapi 3 seri di RSUP Sanglah Denpasar tahun 2018. Metode yang digunakan dalam penelitian ini ialah deskriptif retrospektif longitudinal menggunakan data rekam medis dari pasien kanker serviks yang menjalani kemoterapi paklitaksel-karboplatin. Selama penelitian, terkumpul sebanyak 76 kasus yang memenuhi kriteria inklusi yang kemudian dianalisis . Median SC sebelum dilakukan kemoterapi ialah 0,79mg/dL dan setelah kemoterapi menjadi 0,71mg/dL. Pada pemeriksaan BUN median sebelum kemoterapi ialah 10,5mg/dL dan setelah dilakukan kemoterapi menjadi 9,70mg/dL. Sebanyak 77,6% pasien memiliki hasil pemeriksaan SC dan/atau BUN dalam rentang normal. Hasil penelitian ini menunjukan bahwa setelah dilakukan kemoterapi paklitaksel-karboplatin tidak memberikan efek samping serius yang dapat menurunkan fungsi ginjal. Kata Kunci : Kanker serviks, kemoterapi, paklitaksel-karboplatin, kreatinin, BUN, RSUP Sanglah Denpasar

Co-Authors Abi Rafdi Azizi Aji Priambodo Alfonso Anggriawan Anak Agung Gede Putra Wiradnyana Arlando Martino Anapaku Aryana, Made Bagus Dwi Bay, Godefridus Paulo Budiana, i Nyoman Gede Budiana Budiana, Nyoman Gede Charles Richard Thene Daniel Hadinata Susanto Danny Aguswahyudi Darmayasa, Putu Bagus Deni Saputra Desak Made Wihandani Dewi, Putu Pradnya Paramitha Dwija, Ida Bagus Nyoman Putra Endang Sri Widiyanti Eric Gradiyanto Ongko Ernantje Hendrik Ernest T. B. Sianturi FLORENCIA Hanny Aditanzil Hanny Aditanzil Hitasari, I Gusti Ayu Made Putri I Gde Sastra Winata I Gede Indra Kumara I Gede Mega Putra I Gede Ngurah Harry Wijaya Surya I Gusti Putu Mayun Mayura I Ketut Surya Negara I Ketut Suwiyoga I Made Darmayasa I Nyoman Gede Budiana I Wayan Megadhana IB Putra Adnyana Ida Bagus Arjuna Ida Bagus Gde Fajar Manuaba Jaqueline Sudiman Johan Qalaba JOHANA SENSY LENI MANNA KADE YUDI SASPRIYANA Kade Yudi Saspriyana Kevin Agastya Duarsa Kirana, Ni Wayan Prabasiwi Kolobani, Matias Kurniasih Zaitun Kusuma, A.A.N Jaya Lingga Arti Saputra, Lingga Arti Luh Putu Iin Indrayani Maker Made Ayu Prabawaty Indraswari Made Bagus Dwi Aryana Made Suyasa Jaya Made Yudha Ganesa Wikantyas Widia MANNA, JOHANA SENSY LENI Mardana, I Wayan Rivandi Pradiyadnya Mardana Marta, Kadek Fajar Ngakan Ketut Darmawan Ni Kadek Ari Chintya Vedantari Ni Kadek Deby Cindra Dewi Ni Komang Vina Indriyani Ni Putu Pramana Saras Utami Ongko, Eric Gradiyanto Ongko, Eric Gradiyanto Ongko Pande Kadek Aditya Prayudi Pande Made Suwanpramana Prayudi, Pande Kadek Aditya Prayudi, Pande Kadek Aditya Prayudi Pujawan, I Gede Agus Putra, Ida Bagus Agung Widnyana Putu Adi Sujana Putra Putu Doster Mahayasa Putu Harrista Indra Pramana Putu Raka Widhiarta Putu Srinata Dampati Rayvany Uil Riyanto, Ari Budi Riza Firman Satria Ronaldo, Fransiscus Ronaldo Ruma, I Made Winarsa Ryan Saktika Mulyana Saspriyana, Kade Yudi Saspriyana Septiani, Winty Septiani Sulaeman, Maman Suprapto Suprapto Surudarma, I Wayan Surya, I Gede Ngurah Harry Wijaya Surya, Wirma Suwarni Suwarni Suwiyoga, Ketut Suwiyoga Suyatno, Sugeng Syaiful Anwar, Agus Setiadi, Suwali, Tasia Irma Endriani Tjokorda Gde Agung Suwardewa Tjokorda Istri Putri Adhyasari Wulandari Wijaya Surya, I Gede Ngurah Harry William Alexander Setiawan Winata, I Gde Sastra Winata Yoga, I Putu Bagus Mulyana Yoga

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