Background: Difficult Airway Management (DAM), characterized by challenges in intubation and ventilation, is a significant concern in general anesthesia. It can lead to fatal complications; the risk of intubation failure has been reported to be as high as 2.6 per 1000 cases in general anesthesia. Despite this, 80% of nurses have not yet demonstrated proficiency in DAM procedures. Therefore, educational institutions must evaluate and enhance students' knowledge with attitudes toward DAM to minimize the risk of complications. Objective: This study aimed to evaluate the knowledge with attitudes of D-IV Anesthesiology Nursing students regarding Difficult Airway Management in general anesthesia. Method: This study used a quantitative cross-sectional design and involved 150 students who were selected through stratified random sampling. The instrument, a Likert scale (1-5) questionnaire, was an adaptation from previous relevant research. It was validated, and the reliability test yielded Cronbach's Alpha values of 0.858 for the knowledge scale and 0.832 for the attitude scale. Result: Data analysis using the non-parametric Spearman's Rho test revealed a significant positive correlation between the knowledge with attitudes of D-IV Anesthesiology Nursing students regarding DAM in general anesthesia (p-value 0.000 < 0.050). Conclusion: Higher knowledge among students is associated with better attitudes regarding the DAM in general anesthesia