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All Journal JOURNAL LA MEDIHEALTICO Wal'afiat Hospital Journal WAL'AFIAT HOSPITAL JOURNAL
Taufan, Wa Ode Sri Apriani
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Efek Ekstrak Bawang Putih (Allium sativum L.) dalam Menekan Pertumbuhan Bakteri Salmonella typhi secara In vitro Taufan, Wa Ode Sri Apriani; Idrus, Hasta Handayani; Nurmadilla, Nesyana; Sodiqah, Yani; Muchtar, Amrizal
Wal'afiat Hospital Journal Vol 5 No 1 (2024): Wal'afiat Hospital Journal
Publisher : Rumah Sakit Ibnu Sina, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/whj.v5i1.129

Abstract

Salmonella typhi is a Gram-negative bacterium that has no spores, moves with peritrichic flagellum, is facultative intracellular and facultative anaerobic. Garlic (Allium sativum) has been known for a long time to be used as a seasoning and medicine. The antibacterial activity of garlic can control pathogenic bacteria, both gram-negative and positive. To determine the effectiveness of Salmonella typhi bacteria growth given garlic extract (Allium sativum). This research is a true experiment post test using disc diffusion method. The higher the concentration of garlic extract (Allium sativum), the greater the inhibition zone obtained. The highest concentration of 100% garlic extract against Salmonella typhi bacteria has an inhibition zone of 14.4 mm with sensitive interpretation. Garlic extract (Allium sativum) has antibacterial effectiveness against the growth of Salmonella typhi bacteria
Efek Ekstrak Bawang Putih (Allium sativum L.) dalam Menekan Pertumbuhan Bakteri Salmonella typhi secara In vitro Taufan, Wa Ode Sri Apriani; Idrus, Hasta Handayani; Nurmadilla, Nesyana; Sodiqah, Yani; Muchtar, Amrizal
Wal'afiat Hospital Journal Vol 5 No 1 (2024): Wal'afiat Hospital Journal
Publisher : Rumah Sakit Ibnu Sina, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/whj.v5i1.129

Abstract

Salmonella typhi is a Gram-negative bacterium that has no spores, moves with peritrichic flagellum, is facultative intracellular and facultative anaerobic. Garlic (Allium sativum) has been known for a long time to be used as a seasoning and medicine. The antibacterial activity of garlic can control pathogenic bacteria, both gram-negative and positive. To determine the effectiveness of Salmonella typhi bacteria growth given garlic extract (Allium sativum). This research is a true experiment post test using disc diffusion method. The higher the concentration of garlic extract (Allium sativum), the greater the inhibition zone obtained. The highest concentration of 100% garlic extract against Salmonella typhi bacteria has an inhibition zone of 14.4 mm with sensitive interpretation. Garlic extract (Allium sativum) has antibacterial effectiveness against the growth of Salmonella typhi bacteria
The Role of Estrogen and Progesterone Fluctuations in the Pathogenesis of Postpartum Psychosis: A Neurobiological Review Taufan, Wa Ode Sri Apriani; Khaerina, Ilma; Japari, Agus
Journal La Medihealtico Vol. 7 No. 2 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i2.3241

Abstract

Postpartum psychosis is an acute psychiatric disorder characterized by rapid onset following childbirth, posing significant risks to both maternal and neonatal safety. Its underlying mechanisms remain incompletely understood; however, fluctuations in reproductive hormones particularly estrogen and progesterone are strongly implicated in its pathogenesis. The abrupt decline of these hormones after delivery may disrupt neurotransmitter systems, especially dopaminergic and GABAergic pathways, thereby precipitating neurobiological imbalance in vulnerable individuals. This study employs a literature review method using a narrative review approach, drawing upon databases such as PubMed, ScienceDirect, and Google Scholar, complemented by manual searches. Following the PRISMA framework, a total of 20 articles met the inclusion criteria and were systematically analyzed. The findings indicate that estrogen demonstrates a more consistent association with psychotic symptomatology, whereas progesterone exerts its effects primarily through its metabolite, allopregnanolone, which modulates the GABAergic system. In addition, genetic predisposition, sleep disturbances, and alterations in neuroplasticity contribute to the condition. Postpartum psychosis therefore emerges as a multifactorial disorder resulting from the complex interplay between hormonal fluctuations and underlying neurobiological vulnerability.
Co-Authors Amrizal Muchtar Japari, Agus Khaerina, Ilma Nurmadilla, Nesyana Sodiqah, Yani