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Amrizal Muchtar
Fakultas Kedokteran Universitas Muslim Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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UJI AKTIVITAS ANTIBAKTERI MINYAK ZAITUN (OLEA EUROPAEA L.) JENIS EXTRA VIRGIN TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS Annisa Salsabilah Salam; Rachmat Faisal Syamsu; Dzul Ikram; Yusriani Mangarengi; Amrizal Muchtar
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.25609

Abstract

Staphylococcus aureus adalah flora normal kulit yang mampu menjadi patogen dan menyebabkan infeksi kulit ringan maupun infeksi berat dengan tanda khas peradangan, abses, dan nekrosis.  Bakteri Staphylococcus aureus resisten terhadap banyak antibiotik sehingga menimbulkan masalah terapi terhadap infeksi, seperti MRSA (Methicillin-Resistant Staphylococcus aureus). Minyak zaitun diketahui mengandung senyawa yang mampu menghambat bahkan membunuh bakteri, yaitu oleuropein, hidroksitirosol dan tirosol, flavonoid, dan minyak atsiri. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antibakteri minyak zaitun (Olea europaea L.) jenis Extra Virgin terhadap bakteri Staphylococcus aureus. Penelitian dilakukan dengan true experimental post test menggunakan metode disc diffusion (metode Kirby Bauer) untuk melihat efektivitas minyak zaitun jenis Extra Virgin dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Dilakukan uji identifikasi bakteri menggunakan pewarnaan gram, uji katalase metode slide, uji katalase metode tabung, dan uji koagulase. Tampak bakteri berbentuk bulat dan berwarna ungu (gram positif) yang bergerombol seperti gambaran rantai anggur, gambaran hasil positif untuk bakteri Staphylococcus aureus. Uji katalase metode slide dan tabung terinterpretasi positif. Hasil dari penelitian ini diperoleh rata-rata zona hambat minyak zaitun extra virgin sebesar 2,64 mm (media 1), 2,62 mm (media 2), 1,94 mm (media 3), dan 1,36 mm (media 4) dengan interpretasi resisten. Pertumbuhan bakteri Staphylococcus aureus mampu dihambat dengan minyak zaitun (Olea europaea L.) jenis Extra Virgin, namun daya hambat sangat lemah.
Pengembangan Aplikasi Laporkes Sebagai Media Komunikasi Antara Masyarakat Biasa, Fasilitas Kesehatan, Puskesmas, dan Dinas Kesehatan Amrizal Muchtar; Mardiyyah Hasnawi; Dzul Ikram; Nur Alam Paku Bumi; Arif Rahman; Nur Alifah Salsabila Yani; Husnul Khatimah
I-Com: Indonesian Community Journal Vol 4 No 2 (2024): I-Com: Indonesian Community Journal (Juni 2024)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33379/icom.v4i2.4604

Abstract

Community Health Center (Puskesmas) is the primary healthcare facility in a city. In its daily operations, Puskesmas must frequently interact with the community, healthcare facilities, and local health departments. Currently, at Puskesmas Tamangapa, there is no information system application that effectively mediates communication among them. Therefore, as community-engaged educators, we endeavored to develop a web-based application to address this issue. The method employed in this community engagement project involves creating an application using PHP and Bootstrap programming and promoting the application's usage at Puskesmas Tamangapa. The outcome is an application named 'Laporkes,' accessible at www.laporkes.com. Our conclusion is that this application is quite effective and well-received by all participants in the awareness campaign, with an anticipated launch in the near future.
Efek Ekstrak Bawang Putih (Allium sativum L.) dalam Menekan Pertumbuhan Bakteri Salmonella typhi secara In vitro Wa Ode Sri Apriani Taufan; Hasta Handayani Idrus; Nesyana Nurmadilla; Yani Sodiqah; Amrizal Muchtar
Wal'afiat Hospital Journal Vol 5 No 1 (2024): Wal'afiat Hospital Journal
Publisher : Rumah Sakit Ibnu Sina, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/whj.v5i1.129

Abstract

Salmonella typhi is a Gram-negative bacterium that has no spores, moves with peritrichic flagellum, is facultative intracellular and facultative anaerobic. Garlic (Allium sativum) has been known for a long time to be used as a seasoning and medicine. The antibacterial activity of garlic can control pathogenic bacteria, both gram-negative and positive. To determine the effectiveness of Salmonella typhi bacteria growth given garlic extract (Allium sativum). This research is a true experiment post test using disc diffusion method. The higher the concentration of garlic extract (Allium sativum), the greater the inhibition zone obtained. The highest concentration of 100% garlic extract against Salmonella typhi bacteria has an inhibition zone of 14.4 mm with sensitive interpretation. Garlic extract (Allium sativum) has antibacterial effectiveness against the growth of Salmonella typhi bacteria
Efek Ekstrak Bawang Putih (Allium sativum L.) dalam Menekan Pertumbuhan Bakteri Salmonella typhi secara In vitro Taufan, Wa Ode Sri Apriani; Idrus, Hasta Handayani; Nurmadilla, Nesyana; Sodiqah, Yani; Muchtar, Amrizal
Wal'afiat Hospital Journal Vol 5 No 1 (2024): Wal'afiat Hospital Journal
Publisher : Rumah Sakit Ibnu Sina, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/whj.v5i1.129

Abstract

Salmonella typhi is a Gram-negative bacterium that has no spores, moves with peritrichic flagellum, is facultative intracellular and facultative anaerobic. Garlic (Allium sativum) has been known for a long time to be used as a seasoning and medicine. The antibacterial activity of garlic can control pathogenic bacteria, both gram-negative and positive. To determine the effectiveness of Salmonella typhi bacteria growth given garlic extract (Allium sativum). This research is a true experiment post test using disc diffusion method. The higher the concentration of garlic extract (Allium sativum), the greater the inhibition zone obtained. The highest concentration of 100% garlic extract against Salmonella typhi bacteria has an inhibition zone of 14.4 mm with sensitive interpretation. Garlic extract (Allium sativum) has antibacterial effectiveness against the growth of Salmonella typhi bacteria
Analisis Riset Hipervirulensi dan Multi Drug Resisten Klebsiella Pneumoniae: Studi Bibliometrik Berbasis VOSviewer Sodiqah, Yani; Aprilani Hattah, Dhian Karina; Muchtar, Amrizal
UMI Medical Journal Vol 9 No 1 (2024): UMI Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/umj.v9i1.310

Abstract

Latar Belakang: Sifat co-transfer Gen pengkode hipervirulensi (hvKP) dan resistensi antibiotik (MDR-KP) Klebsiella Pneumoniae memfasilitasi konvergensi, membentuk superbug yang berpotensi menyebabkan wabah dengan gejala berat dan tak terobati. Untuk mengidentifikasi tema riset terbaru mengenai hvKP-MDR-KP, digunakan analisis berbasis co-occurance dari VOSviewer. Studi ini membantu mengubah metadata publikasi menjadi visualisasi kata kunci sesuai tema penelitian atau cluster pada disiplin ilmu tertentu, dan dianalisis berbasis publikasi dan keilmuan. Isi: Riset hvKP dan MDR-KP mulai meningkat sejak tahun 2020, didominasi dari negara China (38 %), diteliti di berbagai bidang, terutama pada bidang mikrobiologi (41%), infeksi (38%) dan farmakologi (28%). Dari 39 artikel terpilih 39 kata kunci co-occurance, membentuk 5 cluster yang saling terkait. Kesimpulan: Resistensi Carbapenem, prevalensi dan hipervirulensi Klebsiella pneumoniae merupakan kata kunci yg paling aktual, sehingga sangat disarankan menjadi tema riset terkait hvKP dan MDR-KP selanjutnya.
Testing The Antimicrobial Effectiveness of Manila Sauce Leaves (Manilkara Zapota L) against Bacteria Escherichia Coli: In Vitro Study Azizah, Namirah Nurjiranah; Kartika, Irna Diyana; Hasbi, Berry Erida; Muchtar, Amrizal; Arsal, Andi St. Fahirah
Journal La Lifesci Vol. 5 No. 2 (2024): Journal La Lifesci
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallalifesci.v5i2.1173

Abstract

Diarrhea remains a significant public health concern globally, particularly affecting children under five years old. Traditional herbal remedies, including Manila Sapodilla (Manilkara zapota L) leaves, have been utilized in Indonesia for treating diarrhea due to their perceived efficacy and safety. This in vitro study aimed to assess the antimicrobial effectiveness of Manila Sapodilla leaf extract against Escherichia coli bacteria, a common cause of diarrhea. True experimental design was employed, utilizing various concentrations (25%, 50%, 75%, and 100%) of Manila Sapodilla leaf extract. The extract was obtained through maceration using ethanol followed by dilution with distilled water. Antimicrobial activity was evaluated using the Kirby-Bauer diffusion method, measuring inhibition zones formed around Escherichia coli colonies. Results demonstrated that Manila Sapodilla leaf extract exhibited inhibitory effects against Escherichia coli at all tested concentrations, albeit with varying degrees of effectiveness. The inhibition zones ranged from 5.37 mm to 8.53 mm, indicating resistance. Positive control using Ciprofloxacin displayed a significantly larger inhibition zone (21.75 mm), indicating sensitivity. These findings suggest the potential of Manila Sapodilla leaf extract as an alternative treatment for Escherichia coli infections. However, further research, including phytochemical analysis and exploration of different extraction methods and concentrations, is warranted to elucidate its therapeutic potential fully. This study contributes to the ongoing search for alternative herbal-based antibiotics to combat bacterial infections effectively.
Efikasi Herba Timi (Thymus Vulgaris L.) Sebagai Antibiotik Terhadap Klebsiella Pneumoniae Nasrun, Muhammad Fikri; Wiriansya , Edward Pandu; Musa, Inna Mutmainnah; Kanang, Indah Lestari Daeng; Muchtar, Amrizal
Innovative: Journal Of Social Science Research Vol. 3 No. 6 (2023): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v3i6.8338

Abstract

Thymus vulgaris dianggap sebagai antiseptik, antimikroba, disenfektan dan obat-obatan bersifat tonik. Thymus vulgaris L. dapat digunakan sebagai bahan makanan dan bahan pengobatan karena komposisinya dengan turunan monoterpen termasuk p-cymene, thymol dan carvacrol. T. vulgaris L. memiliki sifat hepatoprotektif serta memiliki efektivitas sebagai agen ekspektoran, agen anti-jerawat, dan menjadi obat fungisida serta antivirus. Tujuan dari penelitian ini adalah untuk menilai kemampuan Thymus vulgaris L. sebagai antiobiotik terhadap Klebsiella pneumoniae dengan mengambil serbuk dari daun tanaman ini. Penelitian yang digunakan adalah penelitian experimental post test dengan menggunakan metode disc diffusion (metode Kirby Bauer) untuk melihat efektivitas dari ekstrak Herba timi (Thymus vulgaris) pada pertumbuhan bakteri Klebsiella pneumoniae. Hasil penelitian menunjukkan bahwa ekstrak daun Herba timi (Thymus vulgaris L.) tidak memiliki aktivitas sebagai antibakteri sehingga tidak dilakukan pengukuran zona hambat pertumbuhan bakteri dan mengkategorikan daya hambat bakteri Klebsiella pneumoniae, walaupun terdapat senyawa kimia aktif dalam daun Herba timi (Thymus vulgaris L.) yaitu alkaloid, saponin, flavonoid, terpenoid, steroid dan tanin.
Faktor Yang Mempengaruhi Timbulnya Tuberculosis Limfadenitis di Rumah Sakit Umum Pusat Wahidin Sudirohusodo Pada Tahun 2021-2023 Cantika Carmelia, Andi Dila; Rijal, Syamsu; Muchtar, Amrizal; Wiriansya, Edward Pandu; Masdipa, Andi
Wal'afiat Hospital Journal Vol 6 No 1 (2025): Wal'afiat Hospital Journal
Publisher : Rumah Sakit Ibnu Sina, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/whj.v6i1.158

Abstract

Tuberculosis is a contagious disease caused by the bacterium Mycobacterium tuberculosis. This bacterium primarily affects the lungs, but it can also spread to other organs. One of the most commonly found forms of extrapulmonary tuberculosis is Tuberculous Lymphadenitis, which is a TB infection that affects the lymph nodes, especially in the cervical (neck) region. There are many factors that can contribute to the development of this disease. This study aims to identify the factors that influence the occurrence of Tuberculous Lymphadenitis at Wahidin Sudirohusodo Central General Hospital in Makassar during the period of 2021 to 2023. This quantitative research uses a cross-sectional approach to determine the risk factors—age, gender, nutritional status, history of tuberculosis, history of contact, diabetes mellitus, HIV status, immunization status, and hypertension—associated with the occurrence of Tuberculous Lymphadenitis. Data collection began with identifying TB cases, followed by tracing the associated risk factors that may lead to Tuberculous Lymphadenitis. The study population included all patients diagnosed with Tuberculous Lymphadenitis at Wahidin Sudirohusodo Central General Hospital from January to December in the years 2021–2023. The sampling technique used was quota sampling, a non-probability method based on non-random selection of a specific number or proportion of participants. A total of 422 samples that met the inclusion criteria were included in the study.The results showed that age, gender, nutritional status, diabetes mellitus, hypertension, and BCG immunization had a significant relationship with the incidence of Tuberculous Lymphadenitis. In contrast, history of tuberculosis, HIV status, and history of contact did not show a significant association with the disease.
Karakteristik Sindrom Dispepsia pada Mahasiswa Angkatan 2021 Fakultas Kedokteran Universitas Muslim Indonesia Firiansyah, Alief Rezeky; P.Amir, Suliati; Muchtar , Amrizal; Hidayati , Prema Hapsari; Nur, Muhammad Jabal
Borneo Journal of Medical Laboratory Technology Vol. 7 No. 2 (2025): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v7i2.9528

Abstract

Dispepsia merupakan gangguan pencernaan yang umum terjadi dan ditandai dengan nyeri atau rasa tidak nyaman di perut bagian atas. Faktor risiko dispepsia meliputi pola makan tidak teratur, stres, infeksi Helicobacter pylori, penggunaan NSAID, serta kebiasaan mengonsumsi makanan tertentu. Mahasiswa, terutama mahasiswa kedokteran, memiliki risiko tinggi mengalami dispepsia akibat pola makan yang kurang teratur dan tingkat stres yang tinggi akibat tuntutan akademik. Oleh karena itu, penelitian ini bertujuan untuk mengetahui karakteristik sindrom dispepsia pada mahasiswa Angkatan 2021 Fakultas Kedokteran Universitas Muslim Indonesia. Jenis penelitian yang digunakan merupakan penelitian deskriptif dengan metode cross sectional. Penelitian ini menunjukkan bahwa angka kejadian dispepsia pada mahasiswa angkatan 2021 Fakultas Kedokteran Universitas Muslim Indonesia mencapai 84 responden. Mayoritas responden adalah perempuan (85,7%). Pola makan tidak teratur ditemukan pada 69% responden, sedangkan 31% memiliki pola makan teratur. Sebagian besar responden 81% jarang mengonsumsi makanan iritatif, sementara 19% sering mengonsumsinya. Tingkat stres juga menjadi faktor yang dominan, di mana 60,7% responden mengalami stres dan 39,3% tidak mengalami stres. Maka dapat disimpulkan bahwa sindrom dispepsia cukup banyak terjadi pada mahasiswa kedokteran, terutama pada perempuan, mereka yang memiliki pola makan tidak teratur, dan yang mengalami stres. Hasil ini menegaskan bahwa pola makan dan stres memiliki pengaruh terhadap kejadian dispepsia pada mahasiswa.
Efektivitas Pemberian Probiotik Bifidobacterium longum Terhadap Pertumbuhan Pseudomonas aeruginosa Pada Mencit (Mus musculus) Adrian, Adrian; Wiriansya, Edward Pandu; Ikram, Dzul; Muchtar, Amrizal; Anshary, Suci Noviyanah; Karim, Marzelina; Fazdlurrahman, Fazdlurrahman; Ahmad, Izhar Fitrah; Faisal, M. Fathir; Usman, Muh. Muflih; Ilham, Muhammad
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.64-72

Abstract

Background Pseudomonas aeruginosa is an opportunistic, Gram-negative bacterium that can cause infections both acutely and chronically. Antibiotics are essential for treating acute bacterial infections. The use of probiotics is one effort to reduce the number of resistant antibiotics. One of the probiotics derived from microorganisms is Bifidobacterium longum. This study was conducted to determine the effectiveness of Bifidobacterium longum on the growth of Pseudomonas aeruginosa in mice (Mus musculus). Methods This study was conducted using the True Experimental Post-test method. The population used was 3- to 4-month-old mice, with a body weight of 20 to 40 grams, as determined by the Federer formula. The mice were fed standard food and given sterile distilled water. A total of 30 mice were tested and divided into five treatment groups. The test carried out is a test of the distribution of the number of colonies. Results Of the five groups studied, the administration of Bifidobacterium longum combined with the antibiotic ceftriaxone in the probiotic intervention group yielded an effective result (p < 0.05), as did the group that received only Bifidobacterium longum probiotics (p < 0.05). at the same time, the other group did not show an effective result (p >0.05). Conclusions Based on the study, it was explained that the administration of Bifidobacterium longum was effective as a supportive and curative group, but not as a preventive measure against the growth of Pseudomonas aeruginosa in mice.
Co-Authors Adrian Adrian Ahmad, Izhar Fitrah Andi Sitti Fahirah Arsal Anggita, Dwi Annisa Salsabilah Salam Anshary, Suci Noviyanah Aprilani Hattah, Dhian Karina Arif Rahman Arsal, Andi St. Fahirah Azizah, Namirah Nurjiranah Cantika Carmelia, Andi Dila Dzul Ikram Dzul Ikram Faisal, M. Fathir Fattah, Nurfachanti Fazdlurrahman, Fazdlurrahman Firiansyah, Alief Rezeky Hadi, Santriani Hasbi, Berry Erida Husni Esa Darussalam, Andi Husnul Khatimah Ikram, Dzul Irna Diyana Kartika Kanang, Indah Lestari Daeng Karim, Marzelina Mardiyyah Hasnawi Masdipa, Andi Maulidhany Tahir, Akina Muhammad Ilham Muhammad Jabal Nur, Muhammad Jabal Musa, Inna Mutmainnah Nasrun, Muhammad Fikri Nesyana Nurmadilla Nur Alam Paku Bumi Nur Alifah Salsabila Yani Nurmadilla, Nesyana P.Amir, Suliati Prema Hapsari Hidayati Rachmat Faisal Syamsu Sitti Fahirah Arsal, Andi Sodiqah, Yani Sulfiani Herawaty, Andi Syamsu Rijal Syarkawi, M. Fathir Faisal Thahir Taufan, Wa Ode Sri Apriani Usman, Muh. Muflih Wa Ode Sri Apriani Taufan Wiriansya , Edward Pandu Wiriansya, Edward Pandu Wulandari, Mustika Yani Sodiqah Yusriani Mangarengi Zulfitriani Murfat