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Intan Nurcahyani
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Medicine & Pharmacology

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Comparison of Metabolite Content between Water Extract and Ethanol Extract of Moringa Leaves (Moringa oleifera): A Systematic Literature Review Lia Fikayuniar; Adinda Khairun Nissa; Zulfa, Adiva Nafila; Astriani Nurjanah; Intan Nurcahyani; Neni Nurlelah; Risti Septanti
Eureka Herba Indonesia Vol. 4 No. 2 (2023): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v4i2.75

Abstract

Extraction with water and ethanol are two common methods used to isolate secondary metabolites from Moringa oleifera. Extraction with water usually produces extracts rich in polar compounds, while extraction with ethanol tends to be better at isolating non-polar compounds. This study aimed to carry out a systematic review related to the comparative study of metabolite content between aqueous extracts and ethanol extracts of Moringa oleifera. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the comparison of the secondary metabolite content of aqueous and ethanol extracts of Moringa oleifera. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Moringa leaf water extract has higher flavonoid and phenolic content than the ethanol extract of Moringa leaves. Meanwhile, the ethanol extract of Moringa leaves contains higher alkaloids and triterpenoids than the aqueous extract of Moringa leaves.
Formulation and Characterization of Solid Tablets Using Solid Dispersion Matrix Technology: A Systematic Literature Review Intan Nurcahyani; M. Abdul Jabar; M. Raka Werdaya; Septanti, Risti; Satrio Adiputra; Nia Yuniarsih
Eureka Herba Indonesia Vol. 4 No. 2 (2023): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v4i2.77

Abstract

The formulation of solid tablet preparations using solid dispersion matrix technology involves the selection of active ingredients, polymer matrices, fillers or enhancers, and lubricants. The active ingredient is the drug component that provides a therapeutic effect to the patient. This study aimed to conduct a systematic review study to explore the formulation and characterization of solid tablet dosage forms using solid dispersion matrix technology. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the formulation and characterization of solid tablet preparations using solid dispersion matrix technology. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Solid dispersion matrix technology is one of the approaches used in the formulation of pharmaceutical preparations, especially solid tablets, to achieve controlled and effective drug release. In this technology, the drug is dispersed homogeneously in a solid polymeric matrix, which acts as a binding agent. The basic principle of solid dispersion matrix technology is that the drug is delivered via gradual release from the polymer matrix.
Risk Factors and Clinical Course of Patients with Acute Kidney Injury: A Systematic Literature Review Intan Nurcahyani; Septanti, Risti; Maya Arfania
Eureka Herba Indonesia Vol. 4 No. 3 (2023): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v4i3.82

Abstract

Acute kidney injury (AKI) is a serious health problem and can be life-threatening if not treated quickly and appropriately. There are several risk factors that can increase a person's chances of experiencing AKI. This study aimed to carry out a systematic review to explore the risk factors for acute kidney injury and the clinical course of acute kidney injury. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding risk factors and clinical overview of acute kidney injury. The search was performed using the terms: (1) " risk factors " OR " Clinical" OR" symptoms " OR" sign " AND (2) " acute kidney injury". There are several risk factors that can increase a person's chances of experiencing acute kidney injury (AKI). These factors can be intrinsic (inside the patient's body) or extrinsic (outside the patient's body). Patients with heart disease or other blood vessel diseases have a higher risk of developing AKI. Cardiovascular risk factors such as high blood pressure, coronary artery disease, heart failure, or chronic kidney disease can contribute to the development of AKI. In conclusion, acute kidney injury is caused by intrinsic and extrinsic risk factors. While the clinical course of patients with acute kidney injury begins with the prerenal, intrinsic, oliguric, diuretic, and recovery phases.
Co-Authors Adinda Khairun Nissa Astriani Nurjanah Fikayuniar, Lia M. Abdul Jabar M. Raka Werdaya Maya Arfania Neni Nurlelah Nia Yuniarsih Risti Septanti Satrio Adiputra Septanti, Risti Zulfa, Adiva Nafila