Article Per Year (5 Year)
p-Index From 2021 - 2026
0.702
P-Index
This Author published in this journals
All Journal VALENSI Muhammadiyah Journal of Geriatric The Avicenna Medical Journal
Sari, Flori R.
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : VALENSI

 1 
The Potential Effect of Honey-derived D-Allulose in Counteracting Hyperglycemia by Time and Dose Dependent Manner in Diabetes Mellitus Sari, Flori R.
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 2, November 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i2.34881

Abstract

Diabetes mellitus has become a worldwide burden due to its persistent, chronic hyperglycemia. D-allulose, a monosaccharide sugar with a 180.16 molecular weight, is widely used as a low-calorie sweetener, is not involved in glucose-related metabolism, and thus does not alter insulin and pancreatic function. This study aimed to evaluate the potential role of honey-derived D-allulose in acute and sub-chronic diabetes mellitus. Diabetic Sprague-Dawley rats were divided into 9 groups and treated with 0.1, 0.2, and 0.4 g/kg BW honey-derived D-allulose for 28, 56, and 84 days. Post-prandial blood glucose levels and body weight were measured every 4 weeks. Significant reductions in post-prandial blood glucose levels were observed on days 56 and 84 treatment with 0.1 g/kg BW D-allulose. More significant reductions were observed on days 28, 56, and 84 of treatment with 0.2 or 0.4 g/kg BW D-allulose. Eighty-four days of treatment with 0.4 g/kg BW D-allulose significantly reduced post-prandial blood glucose levels compared to all groups. We identified that honey-derived D-allulose reduced post-prandial blood glucose levels in a dose- and time-dependent manner. Thus, honey-derived D-allulose may provide beneficial support for diabetic conditions not only as a sweetener but also as a pharmacological treatment.
Co-Authors Ekayanti, Fika Fadhilah, Marita Risahmawati, Risahmawati Saiful Anwar