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All Journal VALENSI Muhammadiyah Journal of Geriatric The Avicenna Medical Journal
Sari, Flori R.
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Studi Potong Lintang Peresepan Obat Pasien Geriatri di Puskesmas Tangerang: Tinjauan Interaksi Obat Sari, Flori R.
Muhammadiyah Journal of Geriatric Vol. 4 No. 2 (2023): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mujg.4.2.152-162

Abstract

Latar Belakang: Pasien geriatri merupakan kelompok pasien yang rentan mengalami efek samping dari interaksi obat mengingat jumlah dan keluhan penyakit yang banyak sehingga pasien geriatri cenderung mendapatkan obat dalam jumlah banyak (polifarmasi) sementara pada saat yang sama fungsi tubuh sudah mulai mengalami penurunan karena proses penuaan. Tujuan: Penelitian ini bertujuan melihat potensi interaksi obat dan faktor-faktor yang mempengaruhi interaksi obat pada pasien geriatri pada sembilan puskesmas di Tangerang. Metode: Penelitian ini dilakukan dengan desain analitik cross-sectional pada data yang diambil selama 14 hari pada sembilan puskesmas di Tangerang dengan metode pengambilan sampel secara purposive total sampling berdasarkan seluruh jumlah pasien geriatri yang diterima. Hasil: Terdapat 270 pasien geriatri (11%) dari total 2410 kunjungan pasien pada sembilan puskesmas di Tangerang selama penelitian. Ditemukan 36 potensi interaksi obat (13%) dari resep obat yang diterima seluruh pasien geriatri. Potensi interaksi obat meningkat bersamaan dengan jumlah pemberian obat (p = 0,00) sementara gender dan usia tidak mempengaruhi potensi interaksi obat pada penelitian ini. Simpulan: Pada penelitian ini didapatkan peningkatan potensi interaksi obat dan terjadi seiring dengan jumlah obat yang diberikan pada pasien geriatri. Dengan demikian, mengurangi jumlah obat pada pasien geriatri dapat mengurangi potensi interaksi obat dan melindungi pasien geriatri terhadap efek samping obat yang tidak diinginkan.
The Potential Effect of Honey-derived D-Allulose in Counteracting Hyperglycemia by Time and Dose Dependent Manner in Diabetes Mellitus Sari, Flori R.
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 2, November 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i2.34881

Abstract

Diabetes mellitus has become a worldwide burden due to its persistent, chronic hyperglycemia. D-allulose, a monosaccharide sugar with a 180.16 molecular weight, is widely used as a low-calorie sweetener, is not involved in glucose-related metabolism, and thus does not alter insulin and pancreatic function. This study aimed to evaluate the potential role of honey-derived D-allulose in acute and sub-chronic diabetes mellitus. Diabetic Sprague-Dawley rats were divided into 9 groups and treated with 0.1, 0.2, and 0.4 g/kg BW honey-derived D-allulose for 28, 56, and 84 days. Post-prandial blood glucose levels and body weight were measured every 4 weeks. Significant reductions in post-prandial blood glucose levels were observed on days 56 and 84 treatment with 0.1 g/kg BW D-allulose. More significant reductions were observed on days 28, 56, and 84 of treatment with 0.2 or 0.4 g/kg BW D-allulose. Eighty-four days of treatment with 0.4 g/kg BW D-allulose significantly reduced post-prandial blood glucose levels compared to all groups. We identified that honey-derived D-allulose reduced post-prandial blood glucose levels in a dose- and time-dependent manner. Thus, honey-derived D-allulose may provide beneficial support for diabetic conditions not only as a sweetener but also as a pharmacological treatment.
Role of Physician’ Characteristics in Drug Prescription: Evaluation From Drug Database in Improving Prescribing Regulation Sari, Flori R.; Anwar, Saiful; Risahmawati, Risahmawati; Fadhilah, Marita; Ekayanti, Fika
The Avicenna Medical Journal Vol. 4 No. 1 (2023): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v4i1.29878

Abstract

Introduction: Drugs prescribing is the most important skill for physicians and is strictly regulated by the government. However, factors that contribute to the drug prescribing are not determined yet. The aim of this study is to identify the possible role of physician character in drug prescribing at primary health centers (PHC).Method: A cross-sectional study was purposely done over fourteen-days at PHCs of Tangerang Districts. All prescriptions (n=2410) registered in the PHC drug-alert system (CIDIA Database) were analyzed descriptively.Result: From 2410 prescriptions registered in the PHC drug alert system, 15% prescriptions were prescribed by male physicians and 85% by the females. During the study, there were 964 drugs prescribed by 6 male physicians, 161 drugs per physician in average. There were 5584 drugs prescribed by 12 female physicians, 465 drugs per physician on average. Female physicians tended to prescribe 4 or more drugs compared to its male counterpart at 14% (p=0.006). However, there was no significant difference of drug interactions observed in the prescriptions prescribed by male or female physicians (p>0.05).Discussion: We identified that physician characteristics including gender played a significant role in the drug prescribing process especially the number of drugs prescribed. Therefore, considering gender differences in prescribing drugs may help the PHCs to improve a better management in drug safety and to comply with the government prescribing regulation.
Age of children contributes to potential drug interaction at nine primary health cares Sari, Flori R.
The Avicenna Medical Journal Vol. 4 No. 2 (2023): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v4i2.34958

Abstract

Introduction: Adverse drug reaction including drug interaction should be prevented early in children’s patients since children are vulnerable subjects due to their biological development process. Our study aimed to identify the potential drug interaction in children’s patients from nine primary health cares (PHC) at Tangerang.Methods: This study was done with an analytical cross-sectional approach at nine PHC. All children patients from age 1 to 18 years old were recruited for two weeks study. All prescriptions were analyzed and categorized for potential drug interactions.Results: We identified 19 mild and moderate but not serious potential drug interactions from 791 prescriptions (2%). The most common mild potential drug interaction is paracetamol and domperidone as well as mefenamic acid and dexamethasone for moderate potential drug interaction. Number of drugs and gender did not significantly correlate to potential drug interactions, but age did (p=0.04).Discussion: We identified that age correlated significantly to potential drug interactions. In brief, the older the patients, the higher the possibility for the drug interactions, thus physicians should be more aware in prescribing drugs to older children’s patients.
Co-Authors Ekayanti, Fika Fadhilah, Marita Risahmawati, Risahmawati Saiful Anwar