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Ujam, Nonye Treasure
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Health Professions Medicine & Pharmacology Public Health

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Jamur dari Mangrove sebagai Sumber Senyawa Metabolit Sekunder Bioaktif yang Berpotensi sebagai Kandidat Antikanker: Review Literatur Kristiani, Ni Kadek Ari; Putra, I Putu Yogi Astara; Putri, Ni Wayan Prasanthi Swarna; Leliqia, Ni Putu Eka; Ujam, Nonye Treasure; Ariantari, Ni Putu
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.6910

Abstract

Cancer was the leading cause of death, which accounting for nearly 10 million deaths globally in 2020. Currently, cancer treatment still relies on chemotherapy, however, most anticancer drugs showed non-specific toxicity to normal cell proliferation resulting in various side effects, and are ineffective against many forms of cancer. In addition, the increasing case of chemoresistance of cancer cells to chemotherapy has boosted the discovery of new anticancer agents. Natural products are known as the origin of several clinically used anticancer agents, e.g. taxol and vincristine. Among natural products, mangrove-derived fungi are of particular scientific interest evidenced by the increasing rate of publications on cytotoxic secondary metabolites reported. Hence, this literature review aims to provide comprehensive information on cytotoxic secondary metabolites isolated from mangrove-derived fungi, which might contribute to the search for anticancer leads from natural resources. Data were collected from original research articles published on scientific-based sources such as Google Scholar, PubMed, Taylor and Francis, Elsevier, and MDPI, in the range of 2011-2022. Fifty-four cytotoxic secondary metabolites with IC50 values below 10 µM were described herein, which were classified in to 8 groups of metabolites. These compounds were reported from 16 genera of mangrove-associated fungi. Among them, Aspergillus and Penicillium were the most frequent producers of cytotoxic metabolites, suggesting their enormous potential as a source of pharmacophores for anticancer candidates.
Aktivitas Antijamur Kombinasi Ekstrak Etanol Kulit Kayu Manis (Cinnamomum burmannii) dan Rimpang Kunyit (Curcuma longa) terhadap Candida albicans Dewi, Ni Komang Ayu Cintia; Waskito, Andreas Gangsar Bayu; Premanadinata, I Komang Yodi; Dewi, Gusti Ayu Indah Pradnya Apsari; Avrillya, Dhea Amanda; Kusuma, Anak Agung Ayu Vivi Trysbiantari; Susila, Cokorda Istri Diah Ari Saci Prabandari; Ujam, Nonye Treasure; Leliqia, Ni Putu Eka; Ariantari, Ni Putu
Jurnal Ilmiah Medicamento Vol 12 No 2 (2026): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i2.12917

Abstract

Background: Recurrent aphthous stomatitis is a common and painful multifactorial inflammatory condition of the oral mucosa, with a global prevalence of 20% and of 8% in Indonesia. The resulting open mucosal ulcerations facilitate opportunistic Candida albicans infection. The current increase in antifungal resistance of up to 40% has prompted research for alternative natural ingredients for safer and more effective treatments.Objective: This study aimed to evaluate the antifungal activity of ethanolic extracts of cinnamon bark and turmeric, both individually and in combination, against C. albicans.Methods: The extracts were obtained through a maceration method with 96% ethanol, and their phytochemical content was analyzed using LC-MS/MS. For the antifungal assay, the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values were determined using a microdilution test, while the effect of the extract combination was evaluated using a checkerboard microdilution method.Results: LC-MS/MS analysis tentatively identified ar-turmerone, bisdemethoxycurcumin, and curcumin in turmeric extract, while cinnamon bark extract contained nitrogen-containing compounds. Turmeric extract showed stronger antifungal activity, with MIC and MFC values of 1,000 µg/mL, while cinnamon bark extract showed MIC and MFC values of 2,000 and >8,000 µg/mL, respectively. The combination of the two extracts led to a stronger inhibitory activity than each extract, resulting in an FICI of 0.14, indicating a synergistic effect.Conclusions: These findings suggested that the combined treatment suppressed fungal growth at much lower concentrations, indicating a strong synergistic interaction between turmeric and cinnamon bark extracts with potential as a natural antifungal agent against C. albicans.
Co-Authors Avrillya, Dhea Amanda Dewi, Gusti Ayu Indah Pradnya Apsari Dewi, Ni Komang Ayu Cintia Kristiani, Ni Kadek Ari Kusuma, Anak Agung Ayu Vivi Trysbiantari Ni Putu Ariantari Ni Putu Eka Leliqia Premanadinata, I Komang Yodi Putra, I Putu Yogi Astara Putri, Ni Wayan Prasanthi Swarna Susila, Cokorda Istri Diah Ari Saci Prabandari Waskito, Andreas Gangsar Bayu