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All Journal Jurnal Borneo Cendekia Riset Informasi Kesehatan
Putri, Sukma Oktafiani
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Optimization and Formulation of Fenofibrate Transfersome Using The Thin Layer Hydration Method Putri, Sukma Oktafiani; Iswandi, Iswandi; Kuncahyo, Ilham
Riset Informasi Kesehatan Vol 12 No 2 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i2.773

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Abstract Background: Fenofibrate is a lipophilic drug that is used to treat hypercholesterolemia and hypertriglyceridemia in patients.. The low solubility of fenofibrate can be improved by creating a phenofibrate transfersome delivery system. The objective of this research was to determine the effect of phosphatidylcholine 90G, Tween 80, with sonication on fenofibrate transfersomesand to obtain the optimum composition of phosphatidylcholine 90G, tween 80, with sonication on critical parameters including particle size, zeta potential, absorption efficiency. For formula optimization, the factorial design method was applied. Phosphatidylcholine 90G composition, tween 80, with sonication were used as independent variables, with particle size, zeta potential, and sorption effectiveness as dependent variables. Method: The optimization was carried out with critical parameters of the fenofibrate transfersomes tested including particle size, zeta potential, and adsorption efficiency. The critical parameter test data were analyzed using factorial design. Result: The results showed that there was an effect of phosphatidylcholine 90G, tween 80, and sonication on fenofibrate transfersomes provide effect by including particle size, zeta potential, and sorption efficiency. Conclusion: The optimum proportion of phosphatidylcholine 90G was 95%, tween 80 was 5%, and sonication was 33,39 time. The transfersome ability of fenofibrate was good in the optimum formula in the particle size test was 23,675 nm and zeta potential 52,231 mv and the entrapment efficiency was 96,915 %. Keyword : Fenofibrat, Transfersome, phospatidicoline 90G, thin film layer, Factorial Design.
Uji Efektivitas Antibakteri Fraksi-Fraksi Bawang Dayak (Eleutherine palmifolia (L.) Merr.) Dan Bioutografi Terhadap Bakteri Pseudomonas aeruginosa Dwiannur, Febriandi Ramadhan; Jaluri, Poppy Dwi Citra; Effendi, Harun; Trifah, Rahmadha; Putri, Sukma Oktafiani; Sanggel, Mario
Jurnal Borneo Cendekia Vol 9 No 1 (2025): Jurnal Borneo Cendekia
Publisher : STIKES Borneo Cendekia Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54411/jbc.v9i1.630

Abstract

Penyakit infeksi merupakan penyakit yang dapat disebabkan oleh berbagai mikrooganisme seperti bakteri. Antibiotik biasanya digunakan untuk mengobati infeksi karena bakteri, tetapi penggunaan antibiotik yang tidak tepat dan dalam jangka waktu lama dapat menyebabkan efek samping. Salah satu tanaman yang dapat dimanfaatkan sebagai obat tradisional adalah umbi bawang Dayak (Eleutherine palmifolia) (L) Merr. Penelitian ini bertujuan untuk mengetahui efektivitas antibakteri fraksi-fraksi bawang dayak (Eleutherine palmifolia (L.) Merr.) serta bioautografi kontak terhadap bakteri Pseudomonas aeruginosa. Metode ekstraksi dengan maserasi menggunakan pelarut etanol 70% dan selanjutnya dilakukan fraksi cair-cair. Dalam fraksi n-heksan terdapat senyawa termasuk flavonoid, alkaloid, dan triterpenoid. Skrining fitokimia menggunakan KLT, dalam fraksi etil asetat memiliki senyawa flavonoid dan triterpenoid dan dalam fraksi air terdapat senyawa flavonoid, saponin, dan tanin. Hasil penelitian didapatkan fraksi n-heksan , fraksi etil asetat, dan air efektif terhadap bakteri Pseudomonas aeruginosa ditandai dengan adanya zona bening.
Co-Authors Dwiannur, Febriandi Ramadhan Effendi, Harun Ilham Kuncahyo, Ilham Iswandi Iswandi Jaluri, Poppy Dwi Citra Sanggel, Mario Trifah, Rahmadha