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All Journal Indonesian Journal of Tropical and Infectious Disease Jurnal Abdi Insani
Endraswari, Pepy
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An Initiative Report on Hospitalized Pulmonary TB Patients Co-Infected by SARS-CoV-2 during the COVID-19 Pandemic from Tertiary Referral Hospitals in Surabaya Effendy, Lyndia; Mertaniasih, Ni Made; Soedarsono, Soedarsono; Endraswari, Pepy
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 2 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i2.38940

Abstract

The enduring effect of SARS-CoV-2 pandemic has been experienced throughout the past and ongoing three years. Incidences of SARS-CoV-2 co-infected tuberculosis patients were reported globally, including in Italy and several European countries and resulted in a more complicated disease with severe clinical features and poorer clinical outcomes. To effectively manage this co-infection, it is important to be informed of the prevalence and characteristics of an acute SARS-CoV-2 co-infection on TB and determining factors of severity. Therefore, early warning signs can be recognized, monitored closely and managed. This retrospective study, carried out on hospitalized TB patients in Dr. Soetomo Hospital and Universitas Airlangga Hospital, Surabaya, Indonesia, used medical records from March 2020 to December 2022. Samples were from inpatients with a molecularly-Gene Xpert MTB/Rif-confirmed tuberculosis, and currently experienced respiratory and fever symptoms that resembles the symptoms of SARS-CoV-2 infection or exacerbation of tuberculosis. They are then screened and examined using a molecular diagnostic test, with real-time RT-PCR for SARS-CoV-2. A total of 54 (0.7%) patients had TB-SARS-CoV-2 co-infection among 7,786 suspected to have TB, of which 35 had Rifampicin Sensitive (TB-RS), while 19 had TB Rifampicin Resistant (TB-RR) co-infected with SARS-CoV-2. The remaining 2,586 suspected TB patients had only MTB, based on the detection methods of X-pert MTB/RIF, but with negative RT-PCR of SARS-CoV-2. The clinical severity and mortality of TB-SARS-CoV2 co-infected patients were significantly associated with the number of co-morbidities (p=0.0156), and serum haemoglobin levels (p=0.0672), in which p value < 0.05 is considered significant.
Epidemiology of Escherichia coli as a Critical Pathogen of Bloodstream Infection Patients in Tertiary Referral Hospital Endraswari, Pepy; Mertaniasih, Ni Made; Setiawan, Firman; Paramita, Ayu Lidya
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 3 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i3.39494

Abstract

Bloodstream infections (BSI), caused primarily by multidrug-resistant Escherichia coli, are a significant cause of morbidity and mortality worldwide. This study aims to evaluate the epidemiology of E. coli as a critical pathogen in patients with bloodstream infections in a tertiary referral hospital. This is a retrospective study using a  descriptive observational research design. This study used a medical record instrument for bloodstream patients in Dr. Soetomo Hospital's inpatient ward with Gram-negative bacteria results of blood cultures in the Clinical Microbiology Laboratory from April 2021 to September 2021. The observed variables include; antimicrobial sensitivity, patient clinical characteristics, demographic data, clinical diagnosis, and clinical outcome. In 6 months, 276 Gram-negative bloodstream infection patients were treated at Dr. Soetomo Hospital. The proportion of E. coli was 17 %.  The main characteristics of patients were over 60 years old (28%), and 54% were female. 63% of E. coli were ESBL, and 9% were carbapenem-resistant microorganisms. High antimicrobial resistance was found in quinolones (100%), ampicillin (93%), piperacillin (74%), tetracycline (72%), ceftriaxone (66%), cefotaxime (65%), ceftazidime (60%), cefazolin (65%), and trimethoprim-sulfamethoxazole (65%). The most common potential determinant profile discovered was linked to immunocompromised status due to malignancy.  The high number of antimicrobial-resistant bacteria showed the importance of strict infection control and updated epidemiology data as a guide for empirical antimicrobial therapy.
TINGKAT PENGETAHUAN, SIKAP DAN PERILAKU TENTANG RESISTENSI ANTIBIOTIK PADA SISWA MADRASAH ALIYAH NEGERI 3 BANYUWANGI, INDONESIA Endraswari, Pepy; Koendhori, Eko Budi; Kusumaningrumm, Deby; Muna, Nafdzu Mahmudatul
Jurnal Abdi Insani Vol 11 No 4 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i4.1910

Abstract

Microbial resistance to antimicrobials, especially antibiotics, has become a global health problem with various adverse impacts. Studies show that resistance to antibiotic drugs increases directly proportional to the number of increases in their consumption. This happens due to the irrational use of antibiotics and inadequate public education. The high incidence of antibiotic use is due to the lack of counseling in the community to increase knowledge and awareness about the wise use of antibiotics. This community service aims to see how the level of knowledge of senior high school students (MAN 3 Banyuwangi) about antibiotic resistance. This community service design is counseling 90 grade XI students and primary data was collected directly from a questionnaire before and after counseling. The evaluation of the questionnaire before and after the counseling showed that educational and counseling activities about antibiotic resistance increased the knowledge of students participating in the counseling at MAN 3 Banyuwangi. It can be concluded that effective educational interventions are essential, including interventions through counseling activities such as community service activities, to improve student understanding so that high school students can play a role in controlling antibiotic resistance.
Co-Authors Ayu Lidya Paramita Eko Budi Koendhori, Eko Budi Kusumaningrumm, Deby Lyndia Effendy Muna, Nafdzu Mahmudatul Ni Made Mertaniasih Setiawan, Firman Soedarsono Soedarsono