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Novandi Purba
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Medicine & Pharmacology

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FORMULATION AND TEST INHIBITORY EFFECT OF MUSHROOMS CREAM PREPARATION ETHANOL EXTRACT AVOCADO SEEDS (PERSEA AMERICANA MILL) AGAINST MALASSEZIA FURFUR IN VITRO Turnip, Nur Ulina M. Br.; Novandi Purba; Novidawati Boru Situmorang; Sarah Gabetta br Napitupulu
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i1.1872

Abstract

Avocado seeds (Persea americana Mill) are household waste that contains secondary metabolites that can be used as antifungal agents. The antifungal activity of pure ethanol extract from avocado seeds (Persea americana Mill) has been tested and shown to have inhibitory effects on the fungus Malassezia furfur. Pityriasis versicolor is one of the diseases that can be treated due to the infection of Malassezia furfur, and skin diseases are generally treated using semi-solid formulations like creams. The objective of this study is to determine the antifungal activity of a cream formulation of ethanol extract from avocado seeds against Malassezia furfur. The method used to test the inhibitory activity of the cream containing ethanol extract from avocado seeds (Persea americana Mill) against Malassezia furfur is the disc diffusion method. Phytochemical screening results indicated that the ethanol extract from avocado seeds contains alkaloids, flavonoids, tannins, and saponins. The cream containing ethanol extract from avocado seeds (Persea americana Mill) was tested at concentrations of 20% (10 grams), 40% (20 grams), and 60% (30 grams), along with a positive control of Ketoconazole 2%. The research results showed that the cream containing ethanol extract from avocado seeds (Persea americana Mill) at concentrations of 20%, 40%, and 60% exhibited inhibitory zones with diameters of 5.85 mm, 6.73 mm, and 7.66 mm, categorizing them as having a moderate inhibitory effect. Therefore, it can be concluded that the greater the concentration of the extract, the larger the diameter of the inhibitory zone." Keywords: Panu, Malassezia furfur, Antifungal, Cream, Avocado seed (Persea americana Mill).
Testing The Effectiveness of An Ethanol Extract Gel Preparation of Kelakai Leaves (Stenochlaena palustris (Burm.F.) Bedd.) on Reducing The Extent of Burns in Male White Rats (Rattus novergicus) Syarifuddin, Aminah; Novandi Purba; Yayuk Rahayu Suyudi; Elliya Siswanti; Syahfitri, Wilda Dani
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2685

Abstract

The wound healing process is essential for restoring body tissue to its original integrity or normal function. This process involves several stages, including the inflammatory, proliferative, and maturation phases. Both internal and external factors play a role in accelerating wound healing. Kelakai leaves are traditionally used as a topical treatment for burns in gel form, as they are safe for use, non-toxic, and do not cause harmful side effects. The most significant effect was observed with the gel formulation containing 15% w/w kelakai leaf extract, which was able to reduce burn wound area by 13.75%. This demonstrates the effectiveness of kelakai leaf extract gel (Stenochlaena palustris (Burm. F.) Bedd.) in the wound healing process. Therefore, the gel has the potential to reduce the extent of burn injuries.The aim of this study was to analyze the effect of various concentrations of ethanol-based kelakai leaf extract gel. As an effort to reduce burn wound area, this research included several stages, starting from the collection of materials and equipment, plant identification, research procedures, to the extraction process of kelakai leaf simplicia using maceration. This was followed by phytochemical screening and gel formulation at concentrations of 5%, 10%, and 15%, which were then tested for effectiveness on male white rats. The data were analyzed using ANOVA with a significance level of p < 0.050. The findings indicate that the gel containing kelakai leaf extract has a significant effect in reducing the burn wound area in rats.
Co-Authors Elliya Siswanti Novidawati Boru Situmorang Nur Ulina M. Br. Turnip Sarah Gabetta br Napitupulu Syahfitri, Wilda Dani Syarifuddin, Aminah Yayuk Rahayu Suyudi