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All Journal Jurnal Tumbuhan Obat Indonesia Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Journal of Islamic Pharmacy Pharmacology and Clinical Pharmacy Research Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Mandala Pharmacon Indonesia Journal of Halal Science and Research
Sadli Syarifuddin
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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STUDI IN SILICO PENGHAMBATAN AKTIVASI TLR2 EKSTRAK ETANOL DAUN SEMANGGI (Marsilea crenata Presl.) Burhan Ma'arif; Destiya Argo Pamuji Fihuda; Faisal Akhmal Muslikh; Sadli Syarifuddin; Begum Fauziyah; Dewi Perwito Sari; Mangestuti Agil
Jurnal Tumbuhan Obat Indonesia Vol 15 No 1 (2022): Jurnal Tumbuhan Obat Indonesia
Publisher : Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jtoi.v15i1.5792

Abstract

Neuroinflamasi dapat menyebabkan Parkinson Disease (PD), dengan salah satu mekanismenya adalah aktivasi berlebih toll-like receptor 2 (TLR2) akibat abnormalitas dan agregasi α-synuclein. Pada penelitian sebelumnya, daun semanggi (Marsilea crenata Presl.) terbukti menghambat progresivitas neuroinflamasi melalui jalur estrogen-receptor (ER) dependent. Penelitian ini bertujuan untuk memprediksi efek antineuroinflamasi daun semanggi pada jalur penghambatan aktivasi TLR2 (3A7B) dengan studi in silico. Senyawa hasil metabolite profiling sekunder dari ekstrak etanol 96% daun semanggi dipreparasi dengan ChemDraw Ultra 12.0, kemudian dilihat sifat farmakokinetik dan farmakodinamiknya dengan webtool SwissADME. Optimasi geometri pada senyawa dilakukan menggunakan Avogadro 1.0.1 dan molecular docking senyawa terhadap reseptor 3A7B dilakukan menggunakan Autodock vina (PyRx 0.8). Tahap visualisasi interaksi dilakukan dengan Biovia Discover Studio 2021, sedangkan nilai toksisitas senyawa dianalisis menggunakan ProTox II online tool. Hasil penelitian menunjukkan terdapat empat senyawa yang memenuhi kriteria farmakokinetik, farmakodinamik, toksisitas, serta mempunyai kemiripan dengan native ligand N-acetyl-D-glucosamine. Oleh karena itu, ekstrak etanol 96% daun semanggi diprediksi memiliki potensi sebagai penghambat progresifitas PD dengan mekanisme antineuroinflamasi.
Persepsi Calon Jamaah Haji Terhadap Program Interprofessional Education Berbasis Kesehatan Haji Sadli Syarifuddin; Dhani Wijaya; Lailatul Masudah
Journal of Islamic Pharmacy Vol 7, No 2 (2022): J. Islamic. Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v7i2.17655

Abstract

Indonesia merupakan negara dengan jumlah penduduk mayoritas beragama Islam. Hal ini juga membuat jumlah pendaftar haji cukup banyak tiap tahun. Calon jamaah haji yang menunggu untuk berangkat cukup banyak dengan waktu tunggu keberangkatan yang cukup lama antara 20 tahun sampai 40 tahun. Hal tersebut menjadikan calon jamaah haji melaksanakan ibadah haji pada usia lansia. Usia lansia mengakibatkan fungsi fisiologi organ tubuh mengalami penurunan sehingga mempengaruhi kondisi fisik dan mental yang dapat menjadi hambatan calon jamaah haji tidak mencapai kondisi isthita’ah. Program Interprofessional Education (IPE) berbasis Kesehatan Haji Fakultas Kedokteran dan Ilmu Kesehatan UIN Maulana Malik Ibrahim Malang dilaksanakan untuk meningkatkan kesehatan CJH agar siap menunaikan ibadah haji dalam kondisi istitha’ah. Tujuan penelitian ini adalah untuk menganalisis persepsi calon jemaah haji terhadap penyelenggaraan pelayanan IPE berbasis kesehatan haji. Penelitian deskriptif kualitatif dengan metode survei ini dilakukan pada bulan Oktober-November 2021 dengan menggunakan instrumen kuesioner. Sebanyak 40 orang calon jemaah haji menjadi responden. Hasil penelitian menunjukkan bahwa calon jemaah haji memiliki indeks persepsi di atas 87% untuk setiap itemnya. Hal ini mengimplementasikan bahwa responden menerima program ini dengan baik dan memiliki persepsi yang sangat baik terhadap program Pendidikan Interprofessional Berbasis Kesehatan Haji. 
Evaluasi Rasionalitas Penggunaan Obat Antihipertensi pada Pasien Prolanis di Puskesmas Kedungkandang Kota Malang Tahun 2022 Rahma, Amila Dzaky; Syarifuddin, Sadli; Wijaya, Dhani
Journal of Islamic Pharmacy Vol 9, No 1 (2024): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v9i1.26182

Abstract

Hipertensi merupakan keadaan dimana pembuluh darah memiliki tekanan darah yang tinggi (tekanan darah sistolik ≥ 140 mmHg dan tekanan diastolik ≥ 90 mmHg) yang terjadi secara konstan. Terapi antihipertensi termasuk dalam program pengelolaan penyakit kronis (prolanis). Penggunaan obat yang rasional bertujuan agar pasien yang menerima terapi sesuai dengan dosis, waktu terapi, dan mendapatkan harga yang terjangkau. Tujuan dari penelitian ini untuk mengetahui profil dan rasionalitas penggunaan obat antihipertensi pada pasien pengelolaan penyakit kronis di Puskesmas Kedungkandang Kota Malang tahun 2022. Penelitian ini merupakan penelitian jenis observasional deskriptif dengan menggunakan data retrospektif. Sampel penelitian berupa 77 rekam medis pasien prolanis 60 tahun yang mendapat terapi antihipertensi dan terdiagnosa hipertensi dengan atau tidak penyakit penyerta pada rekam medis pasien prolanis bulan Januari hingga Desember 2022, selebihnya dieksklusikan. Obat antihipertensi yang digunakan antara lain amlodipin (57,80%), kandesartan (15,77%), bisoprolol (11,44%), valsartan (3,71%), nifedipin (3,40), hidroklorotiazid (3,09%), kaptopril (2,94%), spironolakton (1,08%), imidapril (0,62%), dan furosemid (0,15%). Rasionalitas tepat indikasi sebesar (100%), tepat penilaian kondisi pasien (96,9%), tepat pemilihan obat (91,5%), tepat dosis (97,5%), dan tepat interval waktu pemberian (100%). Kesimpulan nilai persentase rasionalitas penggunaan obat antihipertensi pada pasien prolanis adalah 97,2%.
Optimization of nanoemulsion hair serum from chia seed oil using the Simplex Lattice Design method Rahmayanti, Mayu; Oktavia, Reza Putri; Amalina, Faidatul; Fadila, Safa Aulia Nur; Nastiti, Ginanjar Putri; Syarifuddin, Sadli
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.27936

Abstract

Hair loss is a hair problem that men and women often experience. Chia seed oil (Salvia hispanica L.) contains linolenic acid, which can stimulate the sebum glands. This research aims to determine the composition of the optimum formula for chia seed oil nanoemulsion hair serum using the Simplex Lattice Design (SLD) method to prove that the characteristics and physical stability of the optimum formula meet the requirements for good preparation. The optimization method was carried out with the help of Design Expert 13 software to optimize the formula by varying Tween 80 (X1) and propylene glycol (X2). The characteristic parameters observed include organoleptic parameters such as pH, viscosity, homogeneity, emulsion type, particle size, zeta potential, polydispersity index, and percent transmittance. The physical stability test was carried out using a 6-cycle test method for organoleptic parameters, pH, and homogeneity. Optimization results show that the optimum composition consists of Tween 80 33.52% and propylene glycol 46.48%. The preparation meets all physical characteristic tests. Physical stability did not significantly change in the pH test, with a significance value of 0.027 in the paired t-test. Based on the research results, it can be concluded that the optimum surfactant and cosurfactant composition in the optimum formula based on optimization using SLD is Tween 80 (33.52%) and propylene glycol (46.48%) with a desirability value of 0.947. The optimum formula for preparing chia seed oil nanoemulsion hair serum meets good physical characteristics and stability requirements.
Optimization of Liquid Shampoo Formula from Chia Seed Oil (Salvia hispanica L) Using the Simplex Lattice Design Method Amalina, Faidatul; Rahmayanti, Mayu; Afrizal, Muhammad; Nastiti, Ginanjar Putri; Syarifuddin, Sadli
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 2: September 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i2.28081

Abstract

Hair is one of the most essential parts of the human body, both men and women; one of the problems with hair that often occurs is hair loss. Chia plants contain sebum gland-stimulating agents with a keratin protein concentration of 23%. The sebaceous glands play a role in facilitating the growth of hair follicles so that hair can thrive and prevent hair loss. This research aims to determine the optimum composition of the prediction formula using Design Expert software and the physical characteristics and stability of liquid shampoo preparations. Optimization was carried out using Design Expert 13 software with two material components, namely HPMC and SLS, and two responses, namely viscosity and foam height. The optimum formula obtained was subjected to characteristic tests and stability tests. The stability test was carried out using the cycling test method by storing the preparation at temperatures of 4◦C and 40◦C for 48 hours. The results of the prediction formula show that component X1 is 0.589307% and X2 is 9.41069%. The one-sample t-test showed that the results were not significantly different at p>0.05 in the two responses. Testing of the optimum formula's physical characteristics and physical stability meets the reasonable requirements for organoleptic tests, homogeneity tests, viscosity tests 414,80±9,94 cPs, foam height tests 7,060±0,11 cm, and pH tests 7,39±0. The 8th run is the optimum formula with a composition of X1 0.589307% and X2 9.41069 % meets the requirements for good physical characteristics tests and physical stability tests.
Utilization of Wungu leaf extract (Graptophyllum pictum (L.) Griff.) in the formulation of spray sunscreen as a halal cosmetic preparation Faidatul Amalina; Mayu Rahmayanti; Sadli Syarifuddin; Ana Fadilia Aktifa
Journal of Halal Science and Research Vol. 5 No. 1 (2024): February
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jhsr.v5i1.9303

Abstract

Ultraviolet (UV) A and Ultraviolet (UV) B rays can also hurt the skin, and sunscreen helps keep the skin awake. Wungu leaf has some potential for sunscreen because it has antioxidant activity that allows it to absorb UV light. Besides considering the security aspect, the formulation of the sunscreen spray also observes the halal critical points of the ingredients used. This study aims to formulate a more comprehensive sunscreen spray halal extract of wungu leaves with variations in the concentration of glycerin, a humectant. Data collection techniques run through descriptive analysis. This is made with variations in glycerin concentration: 5%, 10%, and 15%. The availability of formulated physical evaluations then included organoleptic tests, homogeneity tests, pH tests, viscosity tests, and test patterns of spraying. According to this study, availability in green, homogenous pH stands at 5.42 – 5.73, viscosity in the 1571 – 1983 cPs, and the targeting pattern at about 3 cm, 5 cm, 10 cm, and 15 cm at 5.67 – 16.6 cm. Therefore, in this study, the conclusion is that the availability of sunscreen spray with variations of glycerin has more physical properties that could be used. The more glycerin is used, the more available viscosity will increase.
Interprofessional Education for Optimizing the Fostering Candidate Pilgrimage Program in Waiting Period to Achieve Istitha’ah Rachmawati, Ermin; Riskiyah, Riskiyah; Dharma Dewi, Tanaya Jati; Wijaya, Dhani; Syarifuddin, Sadli; Aisa, Amalia Nur; indrawan, Doby
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 14, No 1 (2025): March
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpki.96864

Abstract

Background: The Faculty of Medicine and Health Sciences of the State Islamic University (FKIK UIN) Malang needs to build recognition in realizing its superior curriculum, namely hajj health through hajj pilgrimage interprofessional education (HIPE) course. On the other hand, there is an opportunity from the Batu City Government and Ministry of Religion to collaborate in fostering the waitingperiod of Prospective Hajj Pilgrims (CJH) to achieve istitha'ah.Objective: This study aimed to compile and evaluate the learning instructional design of the Hajj Pilgrimage Interprofessional Education (HIPE) program as a manifestation of the superior curriculum of FKIK UIN Malang which is part of the prospective hajj pilgrimage waiting period program of the Batu city government.Research Method: This research was conducted from June to December 2023. The participants of the study included the executive board of faculty incluring dean and vice dean, head of medical bachelor and bachelor of pharmacy educational program, head of the ministry of religion, the hajj and umrah organization division, head program director of the health service district and from 5 primary health center, along with hajj pilgrimage candidate of Batu city in 2023. The data used was primary data from the program satisfaction survey questionnaire and secondary data in the form of formal documents.Results: The learning instructional design has been approved by the faculty leader, head of medical and pharmacy bachelor program, head of ministry of religion, and head of Batu city health office in Focus Group Discussion meeting with the topic of Hajj Health Superior Curriculum marked by the issuance of the MoU, the organizational structure of the faculty unit called Unit of Medical and Health Profession Education (UMHPE), and the Dean's Decree for the unit in charge. The organizational structure involved all parties including the ministry of religion of Batu city, the health officer and hajj program director in 5 primary health centers in the Batu city, and the Faculty with its study program. Longitudinal courses in 2 bachelor program was arranged with a spiral curriculum entitled HIPE 1, 2, 3. HIPE 3 as the final course applied the Project Based Learning (PJBL) approach providing intervention program to achieve istitha'ah which is implemented through hajj pilgrimage candidate serial home visits. The quality cycle has been applied in the entire series of learning programs. The results of the satisfaction survey from hajj pilgrimage candidate and external stakeholders showed a positive response to the HIPE program and the objectives of HIPE itself.Conclusion: The HIPE learning prototype as a superior curriculum of FKIK UIN Malang to foster hajj pilgrimage candidate during the waiting period in Batu City already facilitated a mutual collaboration between FKIK UIN Malang, the Health Office and the Ministry of Religion of Batu City.
Identification of Drug Related Problems (DRPs) Based on Drug and Dosage Selection in Type 2 Diabetes Mellitus Patients Wijaya, Dhani; Rahmadanita, Fathia Faza; Atmaja, Ria Ramadhani Dwi; Syarifuddin, Sadli; Mutiah, Roihatul; Habibah, Atiqoh Nur; Nafisah, Fika Sayyidatun
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.61653

Abstract

Pharmacological therapy for type 2 diabetes mellitus involves more than one type of drug, this increases the potential for Drug Associated Problems (DRPs) in terms of selecting the type and dose of the drug. This study aimed to determine the treatment profile and identify the occurrence of DRPs based on drug selection and dosage in patients with type 2 diabetes mellitus. This descriptive observational study was conducted in October 2022 in the medical record room of one general hospital in Batu, East Java. The study sample was obtained by total sampling using 36 medical records of inpatients with type 2 diabetes mellitus without complications. Identification of DRPs based on The Pharmaceutical Care Network Europe (PCNE) V.9.1 guidelines. The results showed that glimepiride (6.45%), insulin (16.13%), a combination of metformin and glimepiride (3.23%), a combination of metformin and insulin (3.23%), and basal-bolus insulin (67.74%) were antidiabetic drugs used by patients. Based on the drug selection, 17 patients were identified as having DRPs where the use of drugs without indication (38.89%) was the most common case. Meanwhile, DRPs based on dose selection were found in 6 patients with 13.89% of cases being too high a drug dose. Based on this study, it can be concluded that there are cases of DRPs based on drug selection and dosage in patients with type 2 diabetes mellitus so improved pharmaceutical services are needed to address this to improve patient safety.
Pengembangan Formula Sediaan Lipstik dari Kombinasi Ekstrak Daun Jati (Tectona grandis L.) dan Daun Pacar (Lawsonia inermis L.) Sebagai Pewarna Alami Rahmayanti, Mayu; Haryadi, Mahardika Chory; Syarifuddin, Sadli; Nastiti, Ginanjar Putri; Anggraini, Dwi; Hasanah, Imrotul; Amiruddin, Muhammad
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.570

Abstract

Lipstik merupakan suatu produk kosmetik yang paling banyak digunakan oleh konsumen, khususnya wanita. Namun, berdasarkan laporan BPOM mulai tahun 2018 hingga 2022, telah ditemukan banyak peredaran kosmetika ilegal yang beredar di pasaran karena mengandung zat warna berbahaya berupa pewarna Merah K3 dan Merah K10. Oleh karena itu, dibutuhkan zat warna alternatif untuk membuat sediaan lipstik agar kesehatan konsumen terjamin. Contoh tanaman yang bisa dijadikan sebagai zat warna alternatif yaitu daun jati muda (Tectona grandis L.) dan daun pacar (Lawsonia inermis L.). Penelitian ini bertujuan untuk memformulasikan sediaan lipstik ekstrak kombinasi daun jati muda (Tectona grandis L.) dan daun pacar (Lawsonia inermis L.) yang memenuhi semua standar evaluasi fisik sediaan lipstik. Daun jati muda diekstraksi dengan metode Ultrasonic Assisted Extraction (UAE), sedangkan daun pacar diekstraksi dengan metode maserasi. Uji evaluasi yang dilakukan meliputi uji organoleptis, uji homogenitas, uji pH, uji oles, uji kekerasan, uji titik lebur, dan uji stabilitas cycling test. Hasil yang diperoleh yaitu semua sediaan lipstik telah memenuhi standar evaluasi sediaan lipstik tapi tidak stabil pada siklus keenam. Kesimpulan penelitian ini yaitu sediaan lipstik memenuhi standar karakteristik sediaan lipstik yang baik tapi tidak stabil setelah uji stabilitas cycling test pada parameter uji pH, uji titik lebur, dan uji kekerasan.
Co-Authors Aisa, Amalia Nur Amalina, Faidatul Ana Fadilia Aktifa Begum Fauziyah Burhan Ma'arif Destiya Argo Pamuji Fihuda Dhani Wijaya Dhani Wijaya, Dhani Dharma Dewi, Tanaya Jati Doby Indrawan Dwi Anggraini Ermin Rachmawati Fadila, Safa Aulia Nur Faidatul Amalina Faisal Akhmal Muslikh Fathia Faza Rahmadanita Ginanjar Putri Nastiti Habibah, Atiqoh Nur Haryadi, Mahardika Chory Hasanah, Imrotul Lailatul Masudah Mangestuti Agil Mayu Rahmayanti Mayu Rahmayanti Muhammad afrizal Muhammad Amiruddin Nafisah, Fika Sayyidatun Oktavia, Reza Putri Rahma, Amila Dzaky Ria Ramadhani Dwi Atmaja riskiyah, Riskiyah - Roihatul Mutiah Sari, Dewi Perwito