Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal The Indonesian Biomedical Journal J.Abdimas: Community Health
Hayuningtyas, Ria Aryani
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Peningkatan Pengetahuan Tata Laksana Trauma Gigi Sulung pada Anggota Komunitas BCApril21: Peningkatan Pengetahuan Tata Laksana Trauma Gigi Sulung pada Anggota Komunitas BCApril21 Hayuningtyas, Ria Aryani; Laksmiastuti, Sri Ratna; Lestari, Sri; Louisa, Marie; Livia Kurniawan, Florencia
J.Abdimas: Community Health Vol 4 No 2 (2023): J.Abdimas: Community Health - November 2023
Publisher : LPPM STIKES Guna Bangsa Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30590/jach.v4n2.697

Abstract

ABSTRACT A study reveals a global prevalence of 22,7% of dental trauma affecting primary teeth through a meta-analysis. Among children aged 0-6 years, oral injuries contribute to 18% of total physical injuries. Dental trauma in children has significant consequences on their oral health. Managing dental trauma in children poses challenges for parents and patients. An education and training activities were held to increase the knowledge of mothers in handling primary dentition dental trauma and management of children’s oral health. This event was carried by Faculty of Dentistry Universitas Trisakti staff members on Mei 2023. This education and training activities were given to Birth Club April 2021 community members. After series of this event, the participant seems to have an increase in knowledge which can be seen in the increase of participant correct post-test answer around 8,82%. Support and participation from the community also contribute to the success of education and training activities. With increased parental knowledge, it is hoped that serious dental health issues in children can be prevented, aiding them in growing up with healthy and strong teeth.
Elephantopus scaber Linn. Leaf Extract Sensitizes Doxorubicin in Inducing Apoptosis in HSC-3 Tongue Cancer Cells through Inhibiting Survivin Activity at Thr34 Sandra, Ferry; Hayuningtyas, Ria Aryani; Ranggaini, Dewi; Pang, Tiffany; Scania, Alifah Evi; Lee, Kyung Hoon
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3096

Abstract

BACKGROUND: Previous research has demonstrated the effect of Elephantopus scaber Linn. leaf extract (ESLE) on various cancer cell lines. However, research on the effects of ESLE on oral squamous cell carcinoma (OSCC), especially tongue cancer, is still lacking. Moreover, the apoptotic mechanisms induced by ESLE are not well understood and require further exploration. Therefore, this study was conducted to investigate the effects of ESLE on cell viability and apoptosis in human squamous cell carcinoma (HSC)-3 tongue cancer cells.METHODS: HSC-3 cells were treated with varying concentrations of ESLE, doxorubicin, and a combination of both. Cell viability and apoptosis were assessed using MTT and Sub-G1 assays. The expression levels of survivin and its phosphorylated form at threonine (Thr)34 were evaluated using Western blot analysis.RESULTS: ESLE exhibited a concentration-dependent cytotoxic effect on HSC-3 cells in decreasing cell viability (Kruskal Wallis, p=0.001) and increasing apoptotic cells (ANOVA, p=0.001) significantly. When combined with doxorubicin, ESLE further enhanced the induction of apoptosis compared with doxorubicin alone. The combined treatment resulted in a decrease in the levels of phosphorylated survivin (p-Surv) Thr34, indicating the inhibition of survivin's anti-apoptotic function.CONCLUSION: ESLE significantly enhances the efficacy of doxorubicin, thereby sensitizing its ability to induce apoptosis in HSC-3 tongue cancer cells. This sensitization occurs through the inhibition of survivin activity, particularly at the Thr34 phosphorylation site. These findings suggest that ESLE could serve as a potential adjuvant to improve the effectiveness of doxorubicin in inducing apoptosis in tongue cancer cells.KEYWORDS: Elephantopus scaber, doxorubicin, tongue cancer, HSC-3 cells, apoptosis, Survivin, Thr34 phosphorylation
Co-Authors Ferry Sandra Florencia Livia Kurniawan Lee, Kyung Hoon Louisa, Marie Pang, Tiffany Ranggaini, Dewi Scania, Alifah Evi Sri Lestari Sri Ratna Laksmiastuti