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Formulasi dan Evaluasi Granul Mukoadhesif Amoksisilin trihidrat dengan Polimer Kitosan Rosmawati; Hartianty, Eka Pebi; Ashfar Kurnia; Siti Mardiyanti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.157

Infeksi saluran pernapasan akut (ISPA) merupakan infeksi saluran pernapasan yang mengakibatkan gangguan aktivitas pernapasan normal. Amoksisilin merupakan antibiotik pilihan pertama yang umumnya diberikan untuk pasien ISPA. Frekuensi penggunaan obat akan memengaruhi kepatuhan pasien dalam minum obat untuk mencapai keberhasilan terapi. Formulasi granul mukoadhesif Amoksisilin trihidrat dengan penambahan polimer kitosan diharapkan dapat mempertahankan sediaan obat agar tertahan berada lebih lama di lambung sehingga dapat memperkecil frekuensi harian penggunaan obat. Formulasi granul mukoadhesif Amoksisilin trihidrat dirancang dengan penambahan polimer kitosan yang diformulasikan dengan metode granulasi basah. Hasil evaluasi menunjukan peningkatan konsentrasi kitosan dalam formula menunjukan profil pelepasan obat yang semakin diperlama yaitu pada formula 6 dengan konsentrasi kitosan 40% dapat mempertahankan pelepasan obat sebesar 41% selama 6 jam pengujian. Kinetika pelepasan obat dari formula 1, 3, 4, dan 5 cenderung mengikuti kinetika pelepasan higuchi, sedangkan pada formula 2 cenderung mengikuti kinetika pelepasan orde nol dan formula 6 cenderung mengikuti kinetika pelepasan orde satu. Peningkatan konsentrasi kitosan pada tiap formula menunjukan daya mukoadhesif yang baik dan profil pelepasan obat yang semakin diperlama. Pelepasan yang paling baik diperoleh dari formula 5 yaitu mampu memperlambat pelepasan obat lebih dari 50% selama 6 jam pengujian dalam medium HCl 0,1N pH 1,2.

Novel Enhalus acoroides Phytosomes: Formulation, Characterization, and Bioavailability Enhancement Siti Mardiyanti; Effionora Anwar; Yesi Desmiaty; Siti Sadiah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1333

Background: Enhalus acoroides (seagrass) possesses valuable bioactive compounds, including quercetin, with potential therapeutic applications, notably antidiabetic effects. However, the poor solubility and low bioavailability of compounds like quercetin limit their clinical efficacy. Phytosomes, phospholipid-based nanocarriers, represent a promising strategy to overcome these limitations. This study aimed to develop and characterize E. acoroides extract-loaded phytosomes to enhance its potential bioavailability. Methods: E. acoroides was collected, processed, and extracted using ultrasound-assisted extraction (UAE). Total phenolic (TPC) and flavonoid content (TFC) were determined. Phytosomes were prepared using the thin-layer hydration method with varying extract-to-soya lecithin ratios (F1=1:1, F2=1:2, F3=1:3). Characterization involved particle size analysis, zeta potential measurement, Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), entrapment efficiency (EE%) determination via HPLC, and in vitro dissolution studies. Results: The UAE extract yielded TPC of 0.318 ± 0.036 mg GAE/g and TFC of 1.023 ± 0.022 mg QE/g. Phytosome formulation F1 (1:1 ratio) exhibited optimal characteristics: particle size of 276.4 nm, PDI of 0.591, zeta potential of -18.0 mV, EE% of 80.47 ± 2.62%, and a spherical morphology. FTIR confirmed complexation. F1 phytosomes demonstrated significantly enhanced dissolution, releasing 87.13% of the entrapped compound over 12 hours compared to the crude extract. Conclusion: E. acoroides extract was successfully encapsulated into phytosomes using a thin-layer method. The F1 formulation (1:1 extract:phospholipid ratio) demonstrated favorable physicochemical properties (nanoparticle size, moderate stability, high EE%) and markedly improved in vitro dissolution, suggesting enhanced bioavailability potential for E. acoroides phytoconstituents.

Novel Enhalus acoroides Phytosomes: Formulation, Characterization, and Bioavailability Enhancement Siti Mardiyanti; Effionora Anwar; Yesi Desmiaty; Siti Sadiah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1333

Background: Enhalus acoroides (seagrass) possesses valuable bioactive compounds, including quercetin, with potential therapeutic applications, notably antidiabetic effects. However, the poor solubility and low bioavailability of compounds like quercetin limit their clinical efficacy. Phytosomes, phospholipid-based nanocarriers, represent a promising strategy to overcome these limitations. This study aimed to develop and characterize E. acoroides extract-loaded phytosomes to enhance its potential bioavailability. Methods: E. acoroides was collected, processed, and extracted using ultrasound-assisted extraction (UAE). Total phenolic (TPC) and flavonoid content (TFC) were determined. Phytosomes were prepared using the thin-layer hydration method with varying extract-to-soya lecithin ratios (F1=1:1, F2=1:2, F3=1:3). Characterization involved particle size analysis, zeta potential measurement, Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), entrapment efficiency (EE%) determination via HPLC, and in vitro dissolution studies. Results: The UAE extract yielded TPC of 0.318 ± 0.036 mg GAE/g and TFC of 1.023 ± 0.022 mg QE/g. Phytosome formulation F1 (1:1 ratio) exhibited optimal characteristics: particle size of 276.4 nm, PDI of 0.591, zeta potential of -18.0 mV, EE% of 80.47 ± 2.62%, and a spherical morphology. FTIR confirmed complexation. F1 phytosomes demonstrated significantly enhanced dissolution, releasing 87.13% of the entrapped compound over 12 hours compared to the crude extract. Conclusion: E. acoroides extract was successfully encapsulated into phytosomes using a thin-layer method. The F1 formulation (1:1 extract:phospholipid ratio) demonstrated favorable physicochemical properties (nanoparticle size, moderate stability, high EE%) and markedly improved in vitro dissolution, suggesting enhanced bioavailability potential for E. acoroides phytoconstituents.

In Vitro Dissolution Profiling and Release Kinetics of Abelmoschus manihot L. Ethanolic Extract Mucoadhesive Granules: A Higuchi Diffusion Model Analysis Siti Mardiyanti; Nila Isnaini Rahmawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 4 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i4.1570

Background: Peptic ulcer disease presents a persistent clinical challenge characterized by a critical imbalance between mucosal defensive mechanisms and aggressive luminal factors, including Helicobacter pylori infection and non-steroidal anti-inflammatory drug administration. The ethanolic extract of Abelmoschus manihot L. possesses potent antioxidant flavonoids, specifically quercetin, which exhibit significant gastroprotective potential. However, the therapeutic efficacy of conventional herbal extracts is often compromised by rapid physiological gastric emptying. The aim of this study was to formulate gastroretentive mucoadhesive granules containing the ethanolic extract of A. manihot using Hydroxypropyl Methylcellulose (HPMC) as a matrix polymer and to elucidate the drug release mechanism through advanced mathematical kinetic modeling. Methods: The extract was standardized for total flavonoid content and antioxidant activity using the DPPH assay. Mucoadhesive granules were engineered via wet granulation with varying concentrations of HPMC (F1: 15%, F2: 20%, F3: 25%) and a constant 15% Carbopol. The formulations underwent rigorous physicochemical characterization, ex vivo wash-off mucoadhesion testing on porcine tissue, and in vitro dissolution profiling in artificial pH 1.2, 6.8, and 7.4 media. Release data were evaluated using Zero-order, First-order, and Higuchi kinetic models, validated via the Akaike Information Criterion (AIC). Results: The standardized extract demonstrated potent antioxidant activity with an IC50 of 27.14 +/- 1.05 mcg/mL and a high total flavonoid content of 162.8 mg QE/g. All granule formulations exhibited excellent flowability. Formula F3 (25% HPMC) displayed superior swelling capacity (15.2-fold expansion) and mucoadhesion (30.0% retention at 60 minutes). Dissolution testing revealed F3 retarded drug release significantly compared to F1, releasing only 41.92% in pH 1.2 over 6 hours. Kinetic analysis confirmed that F3 strictly followed the Higuchi diffusion model, indicating release governed by diffusion through the swollen polymer matrix. Conclusion: The HPMC-Carbopol mucoadhesive granules of A. manihot successfully achieved sustained release and enhanced structural mucoadhesion. Formula F3 represents a mechanistically sound gastroretentive delivery system, driven by complex polymer hydration dynamics, for the localized management of peptic ulcers.

In Vitro Dissolution Profiling and Release Kinetics of Abelmoschus manihot L. Ethanolic Extract Mucoadhesive Granules: A Higuchi Diffusion Model Analysis Siti Mardiyanti; Nila Isnaini Rahmawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 4 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i4.1570

Background: Peptic ulcer disease presents a persistent clinical challenge characterized by a critical imbalance between mucosal defensive mechanisms and aggressive luminal factors, including Helicobacter pylori infection and non-steroidal anti-inflammatory drug administration. The ethanolic extract of Abelmoschus manihot L. possesses potent antioxidant flavonoids, specifically quercetin, which exhibit significant gastroprotective potential. However, the therapeutic efficacy of conventional herbal extracts is often compromised by rapid physiological gastric emptying. The aim of this study was to formulate gastroretentive mucoadhesive granules containing the ethanolic extract of A. manihot using Hydroxypropyl Methylcellulose (HPMC) as a matrix polymer and to elucidate the drug release mechanism through advanced mathematical kinetic modeling. Methods: The extract was standardized for total flavonoid content and antioxidant activity using the DPPH assay. Mucoadhesive granules were engineered via wet granulation with varying concentrations of HPMC (F1: 15%, F2: 20%, F3: 25%) and a constant 15% Carbopol. The formulations underwent rigorous physicochemical characterization, ex vivo wash-off mucoadhesion testing on porcine tissue, and in vitro dissolution profiling in artificial pH 1.2, 6.8, and 7.4 media. Release data were evaluated using Zero-order, First-order, and Higuchi kinetic models, validated via the Akaike Information Criterion (AIC). Results: The standardized extract demonstrated potent antioxidant activity with an IC50 of 27.14 +/- 1.05 mcg/mL and a high total flavonoid content of 162.8 mg QE/g. All granule formulations exhibited excellent flowability. Formula F3 (25% HPMC) displayed superior swelling capacity (15.2-fold expansion) and mucoadhesion (30.0% retention at 60 minutes). Dissolution testing revealed F3 retarded drug release significantly compared to F1, releasing only 41.92% in pH 1.2 over 6 hours. Kinetic analysis confirmed that F3 strictly followed the Higuchi diffusion model, indicating release governed by diffusion through the swollen polymer matrix. Conclusion: The HPMC-Carbopol mucoadhesive granules of A. manihot successfully achieved sustained release and enhanced structural mucoadhesion. Formula F3 represents a mechanistically sound gastroretentive delivery system, driven by complex polymer hydration dynamics, for the localized management of peptic ulcers.

PELATIHAN PENGELOLAAN DATA POSYANDU BERBASIS DIGITAL BAGI IBU-IBU KADER POSYANDU DI POSYANDU GATOT KACA 2 Siti Mardiyanti; Selfia Isnaini Janah; Davina Trixie Evania Dinata; Emiliana Ema Tukan
Prosiding Dedikasi: Pengabdian Mahasiswa Kepada Masyarakat Vol. 5 No. 2 (2026): PROSIDING DEDIKASI
Publisher : Universitas Pamulang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Perkembangan teknologi informasi telah membawa perubahan yang signifikan dalam penyelenggaraan pelayanan publik, termasuk pada layanan kesehatan berbasis masyarakat seperti Posyandu. Meskipun demikian, pada banyak Posyandu proses pencatatan dan pengelolaan data masih dilakukan secara manual, yang berpotensi menimbulkan berbagai permasalahan, antara lain kesalahan penginputan data, keterlambatan dalam penyusunan laporan, rendahnya akurasi informasi, serta risiko kehilangan atau kerusakan arsip. Kondisi tersebut dapat menghambat efektivitas pelayanan kesehatan serta mengurangi kualitas data yang dibutuhkan dalam pengambilan keputusan dan perencanaan program kesehatan. Berdasarkan permasalahan tersebut, kegiatan pengabdian kepada masyarakat ini bertujuan untuk mengoptimalkan kapasitas kader Posyandu dalam mengelola data administrasi melalui pemanfaatan sistem informasi Posyandu berbasis digital yang mudah dioperasikan. Metode pelaksanaan kegiatan meliputi tahap sosialisasi mengenai urgensi transformasi digital dalam pelayanan kesehatan masyarakat, pelatihan penggunaan aplikasi pencatatan data Posyandu, praktik langsung penginputan dan pengelolaan data, serta pendampingan berkelanjutan guna memastikan kader mampu menguasai seluruh fitur aplikasi secara mandiri. Hasil kegiatan menunjukkan adanya peningkatan yang signifikan pada pemahaman kader terkait pentingnya administrasi berbasis digital, peningkatan keterampilan teknis dalam pengelolaan data Posyandu, serta peningkatan efisiensi dan ketepatan waktu dalam proses pelaporan kegiatan. Selain itu, penerapan sistem digital juga membantu menciptakan data yang lebih terstruktur, akurat, dan mudah diakses. Dengan demikian, digitalisasi pengelolaan data Posyandu dapat menjadi solusi strategis dalam mendukung peningkatan kualitas pelayanan kesehatan masyarakat secara berkelanjutan.

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