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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Farmasi Indonesia
Siti Mardiyanti
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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Formulasi dan Evaluasi Granul Mukoadhesif Amoksisilin trihidrat dengan Polimer Kitosan Rosmawati; Hartianty, Eka Pebi; Ashfar Kurnia; Siti Mardiyanti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.157

Abstract

Infeksi saluran pernapasan akut (ISPA) merupakan infeksi saluran pernapasan yang mengakibatkan gangguan aktivitas pernapasan normal. Amoksisilin merupakan antibiotik pilihan pertama yang umumnya diberikan untuk pasien ISPA. Frekuensi penggunaan obat akan memengaruhi kepatuhan pasien dalam minum obat untuk mencapai keberhasilan terapi. Formulasi granul mukoadhesif Amoksisilin trihidrat dengan penambahan polimer kitosan diharapkan dapat mempertahankan sediaan obat agar tertahan berada lebih lama di lambung sehingga dapat memperkecil frekuensi harian penggunaan obat. Formulasi granul mukoadhesif Amoksisilin trihidrat dirancang dengan penambahan polimer kitosan yang diformulasikan dengan metode granulasi basah. Hasil evaluasi menunjukan peningkatan konsentrasi kitosan dalam formula menunjukan profil pelepasan obat yang semakin diperlama yaitu pada formula 6 dengan konsentrasi kitosan 40% dapat mempertahankan pelepasan obat sebesar 41% selama 6 jam pengujian. Kinetika pelepasan obat dari formula 1, 3, 4, dan 5 cenderung mengikuti kinetika pelepasan higuchi, sedangkan pada formula 2 cenderung mengikuti kinetika pelepasan orde nol dan formula 6 cenderung mengikuti kinetika pelepasan orde satu. Peningkatan konsentrasi kitosan pada tiap formula menunjukan daya mukoadhesif yang baik dan profil pelepasan obat yang semakin diperlama. Pelepasan yang paling baik diperoleh dari formula 5 yaitu mampu memperlambat pelepasan obat lebih dari 50% selama 6 jam pengujian dalam medium HCl 0,1N pH 1,2.
Novel Enhalus acoroides Phytosomes: Formulation, Characterization, and Bioavailability Enhancement Siti Mardiyanti; Effionora Anwar; Yesi Desmiaty; Siti Sadiah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1333

Abstract

Background: Enhalus acoroides (seagrass) possesses valuable bioactive compounds, including quercetin, with potential therapeutic applications, notably antidiabetic effects. However, the poor solubility and low bioavailability of compounds like quercetin limit their clinical efficacy. Phytosomes, phospholipid-based nanocarriers, represent a promising strategy to overcome these limitations. This study aimed to develop and characterize E. acoroides extract-loaded phytosomes to enhance its potential bioavailability. Methods: E. acoroides was collected, processed, and extracted using ultrasound-assisted extraction (UAE). Total phenolic (TPC) and flavonoid content (TFC) were determined. Phytosomes were prepared using the thin-layer hydration method with varying extract-to-soya lecithin ratios (F1=1:1, F2=1:2, F3=1:3). Characterization involved particle size analysis, zeta potential measurement, Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), entrapment efficiency (EE%) determination via HPLC, and in vitro dissolution studies. Results: The UAE extract yielded TPC of 0.318 ± 0.036 mg GAE/g and TFC of 1.023 ± 0.022 mg QE/g. Phytosome formulation F1 (1:1 ratio) exhibited optimal characteristics: particle size of 276.4 nm, PDI of 0.591, zeta potential of -18.0 mV, EE% of 80.47 ± 2.62%, and a spherical morphology. FTIR confirmed complexation. F1 phytosomes demonstrated significantly enhanced dissolution, releasing 87.13% of the entrapped compound over 12 hours compared to the crude extract. Conclusion: E. acoroides extract was successfully encapsulated into phytosomes using a thin-layer method. The F1 formulation (1:1 extract:phospholipid ratio) demonstrated favorable physicochemical properties (nanoparticle size, moderate stability, high EE%) and markedly improved in vitro dissolution, suggesting enhanced bioavailability potential for E. acoroides phytoconstituents.
Novel Enhalus acoroides Phytosomes: Formulation, Characterization, and Bioavailability Enhancement Siti Mardiyanti; Effionora Anwar; Yesi Desmiaty; Siti Sadiah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1333

Abstract

Background: Enhalus acoroides (seagrass) possesses valuable bioactive compounds, including quercetin, with potential therapeutic applications, notably antidiabetic effects. However, the poor solubility and low bioavailability of compounds like quercetin limit their clinical efficacy. Phytosomes, phospholipid-based nanocarriers, represent a promising strategy to overcome these limitations. This study aimed to develop and characterize E. acoroides extract-loaded phytosomes to enhance its potential bioavailability. Methods: E. acoroides was collected, processed, and extracted using ultrasound-assisted extraction (UAE). Total phenolic (TPC) and flavonoid content (TFC) were determined. Phytosomes were prepared using the thin-layer hydration method with varying extract-to-soya lecithin ratios (F1=1:1, F2=1:2, F3=1:3). Characterization involved particle size analysis, zeta potential measurement, Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), entrapment efficiency (EE%) determination via HPLC, and in vitro dissolution studies. Results: The UAE extract yielded TPC of 0.318 ± 0.036 mg GAE/g and TFC of 1.023 ± 0.022 mg QE/g. Phytosome formulation F1 (1:1 ratio) exhibited optimal characteristics: particle size of 276.4 nm, PDI of 0.591, zeta potential of -18.0 mV, EE% of 80.47 ± 2.62%, and a spherical morphology. FTIR confirmed complexation. F1 phytosomes demonstrated significantly enhanced dissolution, releasing 87.13% of the entrapped compound over 12 hours compared to the crude extract. Conclusion: E. acoroides extract was successfully encapsulated into phytosomes using a thin-layer method. The F1 formulation (1:1 extract:phospholipid ratio) demonstrated favorable physicochemical properties (nanoparticle size, moderate stability, high EE%) and markedly improved in vitro dissolution, suggesting enhanced bioavailability potential for E. acoroides phytoconstituents.
Co-Authors Ashfar Kurnia Effionora Anwar Hartianty, Eka Pebi Mochammad Imron Awalludin Siti Sadiah Yesi Desmiaty, Yesi