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In Vitro Study of Garcinia dulcis (Roxb.) Kurz Leaves Extract against Hepatitis C Virus: Garcinia dulcis Leaves Extract against Hepatitis C Virus Apriyanto, Dadan Ramadhan; Hartati, Sri; Sri Wahyuni, Tutik; Inge Lusida, Maria
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.20

Garcinia dulcis is a plant commonly used in traditional medicine in tropical regions. It has anti-bacterial, anti-inflammatory, anti-tumor, and anti-malaria properties. Despite its potential benefits, studies on its effectiveness as an antiviral are limited. This study investigated the antiviral properties of G. dulcis leaf extract against the JFH-1 strain genotype 2a as a treatment for Hepatitis C Virus (HCV). Huh7it-1 cells infected with the HCV genotype 2a strain JFH-1 were used to determine the antiviral effect of methanol extracts of G. dulcis leaves (GD-LE). GD-LE antiviral activity was investigated using a focus-forming assay for anti-HCV and 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay for cytotoxicity. A time-of-addition study of anti-HCV was also performed to determine the mode of action of GD-LE. The results showed that GD-LE inhibited HCV replication with an IC50 of 17.06 µg/mL without giving any toxicity to the cells. The mode-of-action of GD-LE was found to inhibit HCV replication in the co-addition and post-infection stages. These findings suggest that GD-LE could be a promising candidate for anti-HCV treatment. However, further study regarding GD-LE bioactive compound isolation needs to be done to prepare an effective antiviral.

PENGEMBANGAN DESA GILI IYANG SEBAGAI PENGHASIL PRODUK KELOR DAN ANGGUR LAUT UNTUK PENGUATAN BLUE-GREEN ECONOMY & HEALTH: DEVELOPMENT OF GILI IYANG VILLAGE AS A PRODUCER OF MORINGA AND SEAGRAPE PRODUCTS TO STRENGTHEN THE BLUE-GREEN ECONOMY AND HEALTH Widyowati, Retno; Ekasari, Wiwied; Sri Wahyuni, Tutik; Melani Hariyadi, Dewi
J-Dinamika : Jurnal Pengabdian Masyarakat Vol 9 No 1 (2024): April
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Secara administratif Gili Iyang masuk dalam wilayah Kabupaten Sumenep, Kecamatan Dungkek. Pulau dengan luas sekitar 9 km2 ini terdiri dari dua desa yaitu Desa Banraas dan Bancamara. Desa ini merupakan desa mitra penelitian dan pengabdian masyarakat dari Fakultas Farmasi dan Universitas Airlangga. Program pengembangan desa mitra berbasis penelitian di wilayah ini merupakan salah satu program unggulan mitra yang sangat bermanfaat untuk masyarakat. Program ini merupakan aplikasi dari beberapa aspek Sustainable Development Goals (SDGs) antara lain no poverty (1), health (3), quality education (4), decent work and economic growth (8), life below water (14), dan life on land (15) serta merupakan penguatan prioritas riset nasional (PRN) bidang Blue-Green Economy dan Health. Program unggulan ini meliputi pengembangan iptek dan sumber daya alam yaitu pengolahan tanaman produk kelor (Moringa oleifera) dan anggur laut (Caulerpa racemosa) sebagai bahan baku obat tradisional dan nutraseutikal sehingga bisa memberikan nilai tambah pada tanaman tersebut. Tanaman kelor dan anggur laut banyak terdapat di daerah tersebut namun pemanfaatannya belum maksimal. Berdasarkan latar belakang tersebut, maka dilakukan Pengembangan Desa Gili Iyang sebagai Penghasil Produk Kelor dan Anggur Laut untuk Penguatan Blue-Green Economy & Health. Hal ini dapat menciptakan peluang usaha baru bagi masyarakat Desa Banraas dan Bancamara sehingga meningkatkan perekonomian dan taraf kesehatan masyarakat desa tersebut. Kegiatan pengabdian pada masyarakat yang dilakukan bertujuan untuk mengembangkan desa wisata Banraas dan Bancamara dalam meningkatkan pengetahuan dan ketrampilan masyarakat setempat terhadap pengembangan produk inovasi yang berasal dari kelor dan anggur Laut.

Pengembangan E-Modul Berbasis Multipel Representasi pada Pembelajaran Flipped Classroom Materi Laju Reaksi Tahta Zilli Arsyka, Azzilani; Sri Wahyuni, Tutik
Jurnal Riset Pendidikan Kimia (JRPK) Vol. 11 No. 2 (2021): Jurnal Riset Pendidikan Kimia (JRPK), Volume 11 Nomor 2 (2021)
Publisher : LPPM Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRPK.112.01

This study aims to develop the e-module of reaction rate topic based on multiple representations with the flipped classroom approach as a student self-study facility and to test the feasibility of the e-module based on its validity and readability responses. This research and development used a 4-D model consisting of 4 stages, namely define, design, develop, and disseminate. However, in this study, the stages carried out only reached the develop stage. The e-module product that has been developed is then validated by three validators consisting of one chemistry education lecturer and two chemistry teachers to test its feasibility in terms of material content and media appearance. Then, e-module was revised according to the suggestions from the validators and tested for its readability based on student responses collected through a questionnaire. The results of the validation data analysis of the developed e-module fulfill the eligibility criteria both in terms of material and media with an average percentage of 91.35% and 91.91%, respectively, in a very good category. Meanwhile, the results of the readability test received a positive responses from students with an average percentage of 82.92% in a good category. Thus, the developed e-module is feasible to be implemented in learning reaction rate topic with the flipped classroom approach. Keywords: e-module, multiple representation,flipped classroom, reaction rate

Uji Validitas dan Respon Siswa Pengembangan E-Modul Kimia Berbasis Science, Environment, Technology, Society (SETS) Terintegrasi Nilai-Nilai Keislaman Pada Materi Sistem Koloid Zeni Aprilia, Lovty; Sri Wahyuni, Tutik
Jurnal Riset Pendidikan Kimia (JRPK) Vol. 13 No. 2 (2023): Jurnal Riset Pendidikan Kimia (JRPK), Volume 13 Nomor 2 (2023)
Publisher : LPPM Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRPK.132.10

Teaching materials that can be used for self-study by students, stimulate students' thinking skills by associating chemical concepts with approaches to science, environment, technology, and society as well as containing the integration of Islamic values are needed so that students get a complete concept andit is hoped that students can apply the concept to the real situations. This research aims to develop e-module based Science, Environment, Technology, and Society (SETS) which is integrated with Islamic values in colloidal system material. This researchand development use 7 stages of the RnD model from Sugiyono, namely potential problems, information gathering, product design, design validation, design revision, product manufacture, and limited product trials. The research instruments were needs analysis questionnaires, validation sheets, and student response questionnaires. E-module that was developed was validated by three validators to measure its validity in terms of material, media, and the integration of Islamic values. Product revisions were carried out according to the suggestions of the validators, then limited tests to find out student responses to the e-module being developed. The results of the validation of material experts, media, and integration of Islamic values successively obtained an average percentage of 96.0%, 95.1%, and 85.0% with very valid categories. The results of student responses obtained an average percentage of 83.6% in the very good category.

In Vitro Study of Garcinia dulcis (Roxb.) Kurz Leaves Extract against Hepatitis C Virus: Garcinia dulcis Leaves Extract against Hepatitis C Virus Apriyanto, Dadan Ramadhan; Hartati, Sri; Sri Wahyuni, Tutik; Inge Lusida, Maria
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.20

Garcinia dulcis is a plant commonly used in traditional medicine in tropical regions. It has anti-bacterial, anti-inflammatory, anti-tumor, and anti-malaria properties. Despite its potential benefits, studies on its effectiveness as an antiviral are limited. This study investigated the antiviral properties of G. dulcis leaf extract against the JFH-1 strain genotype 2a as a treatment for Hepatitis C Virus (HCV). Huh7it-1 cells infected with the HCV genotype 2a strain JFH-1 were used to determine the antiviral effect of methanol extracts of G. dulcis leaves (GD-LE). GD-LE antiviral activity was investigated using a focus-forming assay for anti-HCV and 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay for cytotoxicity. A time-of-addition study of anti-HCV was also performed to determine the mode of action of GD-LE. The results showed that GD-LE inhibited HCV replication with an IC50 of 17.06 µg/mL without giving any toxicity to the cells. The mode-of-action of GD-LE was found to inhibit HCV replication in the co-addition and post-infection stages. These findings suggest that GD-LE could be a promising candidate for anti-HCV treatment. However, further study regarding GD-LE bioactive compound isolation needs to be done to prepare an effective antiviral.

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