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Alterations in Blaood Profiles and Spleen Tissue Following Purple Sweet Pota-to Anthocyanin Extract Treatment in Restraint-Stressed Mice: Blood Profiles and Spleen Tissue Following Purple Sweet Potato Anthocyanin Extract Treatment Kurnianingsih, Nia; Artamevia, Dian; Hasanah, Dian; Harbiyanti, Novita Titis; Ratnawati, Retty
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.19

Stress is associated with broad changes in blood and immune cell dysfunction, which are correlated with the spleen as a secondary lymphoid organ. Anthocyanin, a plant bioactive compound from purple sweet potatoes, has previously been reported to have a beneficial effect on stress response behavior. However, the limited studies evaluated anthocyanin's effect on blood profiles and spleen tissue under stress. Therefore, this study aimed to explore the effect of total anthocyanin extract (ANC) from purple sweet potatoes (PSP) on the blood profiles and spleen tissue of restraint stressed mice. A total of 20 male adult BALB/c mice were divided into control (CTRL), stress (STR), stress + ANC 10 mg/kgBW (STR+ANC10), stress + ANC 20 mg/kgBW (STR+ANC20), and stress + ANC 40 mg/kgBW (STR+ANC10). Restraint stress was applied two hours/day for 14 days. An automatic blood analyzer was used for blood profiling. Immunoblotting of caspase-3 and hematoxylin-eosin-stained histological slides were observed for spleen tissue analysis. Combination of STR and ANC treatment reduced the erythrocyte count, hemoglobin level, and leucocyte count. The ANC-treated groups had a higher percentage of lymphocytes and a lower percentage of granulocytes. The expression of caspase-3 declined among ANC-treated groups. Spleen extramedullary erythropoiesis, vacuolization, and white pulp involution were demonstrated in stress and ANC-treated animals. In summary, restraint stress modified the blood cell profiles and spleen tissue in the mice model. Further research is necessary to evaluate the mechanism of ANC during stress on blood cells and splenic tissue repair enhancement.

Parkinson’s Disease Quality of Life: Disease Severity Outweighs Pain Impact Raisa, Neila; Maziya, Yulianda; Rahma, Annisa; Harbiyanti, Novita Titis; Kurniawan, Shahdevi Nandar
Jurnal Kesehatan Prima Vol 18, No 2 (2024): AUGUST
Publisher : poltekkes kemenkes mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jkp.v18i2.1657

Introduction: Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease, progressively affecting both motor and non-motor systems in patients. In addition to the commonly recognized motor symptoms such as tremor, rigidity, and bradykinesia, non-motor symptoms such as chronic pain are often underdiagnosed. Pain in Parkinson's patients can manifest in various forms, including musculoskeletal pain, neuropathic pain, and dystonic pain. While pain is not a primary symptom defining Parkinson's, its impact on patients' quality of life is profound, contributing to reduced mobility, sleep disturbances, increased risk of falls, and poor mental health, including depression and anxiety. This study aimed to explore the relationship between the severity of Parkinson's disease, pain levels, and quality of life in Parkinson's patients. Method: A cross-sectional observational study was conducted at the Neurology Clinic of RSUD Dr. Saiful Anwar in East Java from October 2023 to March 2024, using purposive sampling techniques. We assessed Parkinson's severity (Hoehn & Yahr scale), pain levels (Numeric Rating Scale), and quality of life (Parkinson's Disease Questionnaire-39 (PDQ-39) Indonesian Version). Result: The study found that PDQ-39 INA scores were significantly associated with Parkinson's disease severity (n = 11, p = 0.012), indicating a significant impact of disease severity on quality of life. However, no significant relationship was found between PDQ-39 scores and pain levels (p = 0.117). Pearson correlation analysis showed no significant relationship between Parkinson's severity scale and pain level (r = 0.461, p = 0.154). Specifically, Parkinson's severity significantly affected PDQ-39 scores (p = 0.001), while pain levels did not have a significant effect (p = 0.399). Conclusion: This study reveals that while pain is a critical issue, it is the severity of Parkinson's disease that has a more substantial impact on patients' quality of life.

Alterations in Blaood Profiles and Spleen Tissue Following Purple Sweet Pota-to Anthocyanin Extract Treatment in Restraint-Stressed Mice: Blood Profiles and Spleen Tissue Following Purple Sweet Potato Anthocyanin Extract Treatment Kurnianingsih, Nia; Artamevia, Dian; Hasanah, Dian; Harbiyanti, Novita Titis; Ratnawati, Retty
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.19

Stress is associated with broad changes in blood and immune cell dysfunction, which are correlated with the spleen as a secondary lymphoid organ. Anthocyanin, a plant bioactive compound from purple sweet potatoes, has previously been reported to have a beneficial effect on stress response behavior. However, the limited studies evaluated anthocyanin's effect on blood profiles and spleen tissue under stress. Therefore, this study aimed to explore the effect of total anthocyanin extract (ANC) from purple sweet potatoes (PSP) on the blood profiles and spleen tissue of restraint stressed mice. A total of 20 male adult BALB/c mice were divided into control (CTRL), stress (STR), stress + ANC 10 mg/kgBW (STR+ANC10), stress + ANC 20 mg/kgBW (STR+ANC20), and stress + ANC 40 mg/kgBW (STR+ANC10). Restraint stress was applied two hours/day for 14 days. An automatic blood analyzer was used for blood profiling. Immunoblotting of caspase-3 and hematoxylin-eosin-stained histological slides were observed for spleen tissue analysis. Combination of STR and ANC treatment reduced the erythrocyte count, hemoglobin level, and leucocyte count. The ANC-treated groups had a higher percentage of lymphocytes and a lower percentage of granulocytes. The expression of caspase-3 declined among ANC-treated groups. Spleen extramedullary erythropoiesis, vacuolization, and white pulp involution were demonstrated in stress and ANC-treated animals. In summary, restraint stress modified the blood cell profiles and spleen tissue in the mice model. Further research is necessary to evaluate the mechanism of ANC during stress on blood cells and splenic tissue repair enhancement.

Parkinsonâ€™s Disease Quality of Life: Disease Severity Outweighs Pain Impact Raisa, Neila; Maziya, Yulianda; Rahma, Annisa; Harbiyanti, Novita Titis; Kurniawan, Shahdevi Nandar
Jurnal Kesehatan Prima Vol. 18 No. 2 (2024): AUGUST
Publisher : poltekkes kemenkes mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jkp.v18i2.1657

Introduction: Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease, progressively affecting both motor and non-motor systems in patients. In addition to the commonly recognized motor symptoms such as tremor, rigidity, and bradykinesia, non-motor symptoms such as chronic pain are often underdiagnosed. Pain in Parkinson's patients can manifest in various forms, including musculoskeletal pain, neuropathic pain, and dystonic pain. While pain is not a primary symptom defining Parkinson's, its impact on patients' quality of life is profound, contributing to reduced mobility, sleep disturbances, increased risk of falls, and poor mental health, including depression and anxiety. This study aimed to explore the relationship between the severity of Parkinson's disease, pain levels, and quality of life in Parkinson's patients. Method: A cross-sectional observational study was conducted at the Neurology Clinic of RSUD Dr. Saiful Anwar in East Java from October 2023 to March 2024, using purposive sampling techniques. We assessed Parkinson's severity (Hoehn & Yahr scale), pain levels (Numeric Rating Scale), and quality of life (Parkinson's Disease Questionnaire-39 (PDQ-39) Indonesian Version). Result: The study found that PDQ-39 INA scores were significantly associated with Parkinson's disease severity (n = 11, p = 0.012), indicating a significant impact of disease severity on quality of life. However, no significant relationship was found between PDQ-39 scores and pain levels (p = 0.117). Pearson correlation analysis showed no significant relationship between Parkinson's severity scale and pain level (r = 0.461, p = 0.154). Specifically, Parkinson's severity significantly affected PDQ-39 scores (p = 0.001), while pain levels did not have a significant effect (p = 0.399). Conclusion: This study reveals that while pain is a critical issue, it is the severity of Parkinson's disease that has a more substantial impact on patients' quality of life.

Epilepsy Smart School: Part Of Anti Stigma Campaign Husna, Machlusil; Damayanti, Ria; Harbiyanti, Novita Titis; Rahma, Annisa; Gumelar, Enggar; Ibrahim, Ananto Suarbhakti; Muhammad, Galang Mahasin; Kurniasari, Dyah Ayu
Caring: Jurnal Pengabdian Masyarakat Vol. 5 No. 3 (2025): CARING Jurnal Pengabdian Masyarakat (Desember 2025)
Publisher : Department of Nursing, Faculty of Health Sciences, Universitas Brawijaya.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.caringjpm.2025.005.03.4

Epilepsy is a neurological condition that is still frequently associated with stigma and misconceptions, particularly in school settings, which can lead to discrimination, social exclusion, and inappropriate seizure management. As part of a community service, The Epilepsy Smart School program was implemented from May to December 2025 in Malang, Indonesia, aiming to improve knowledge, reduce stigma, and promote inclusion for students with epilepsy through interactive education and seizure first-aid simulations. Evaluation was conducted using a pre–post assessment design involving 30 participants (students and teachers) selected through convenience sampling. The results showed a significant increase in knowledge scores from 81.0 to 98.6, reflecting a better understanding of epilepsy and appropriate seizure management. In addition, stigma was reduced, as indicated by increased social acceptance, empathy, and willingness to interact with and support inclusive education without segregation. Although there was a decrease in post-test participation and no long-term evaluation was conducted, the program proved effective in improving both cognitive and social attitude aspects. These findings suggest that participatory school-based health education has the potential to create a more inclusive, supportive, and stigma-free environment for individuals with epilepsy.

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