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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences The Journal of Experimental Life Sciences (JELS) MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB Indonesian Journal of Chemistry JSMARTech : Journal of Smart Bioprospecting and Technology Narra J Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Masagi: Jurnal Pendidikan Karakter Idarotuna: Jurnal Manajemen Pendidikan Islam
Kurnianingsih, Nia
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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An in Silico Study of the Cathepsin L Inhibitory Activity of Bioactive Compounds in Stachytarpheta jamaicensis as a Covid-19 Drug Therapy Utami, Juliyatin Putri; Kurnianingsih, Nia; Faisal, Mohammad Reza
Makara Journal of Science Vol. 26, No. 1
Publisher : UI Scholars Hub

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Abstract

Inhibition of cathepsin L (Cat L) can be considered a target for COVID-19 treatment. Starchytapheta jamaicensis is a plant from the Verbenaceae family that is commonly used for medicinal purposes. This study aims to analyze the inhibitory activities of compounds of Stachytarpheta jamaicensis toward Cat L by computational docking analysis. Ten compounds contained in the extracts (i.e., α-spinasterol, apigenin, luteolol-7-glucuronide, friedelin, hispidulin, chlorogenic acid, ipolamiide, geraniol, hentriacontane, and γ-aminobutyric acid) were selected as ligands; decanoyl-arg-val-lys-arg-chloromethylketone and oxocarbazate were used as the reference. Computational docking analysis was performed using Autodock Vina integrated into PyRx 8.0 and visualized using the Discovery Studio Visualizer v19.1.0.18287 (2019 version) based on the scoring functions. Seven bioactive compounds were bound more strongly than decanoyl-arg-val-lys-arg-chloromethylketone: α-spinasterol, apigenin, luteolol-7-glucuronide, friedelin, hispidulin, chlorogenic acid, and ipolamiide. However, all bioactive compounds were bound with less strength than oxocarbazate. Apigenin showed the best affinity, with much hydrogen bonding, and had the same ASN18 residue as Cat L inhibitor 1. PreADMET showed that all compounds of S. jamaicensis did not have hepatotoxicity, mutagenic, and carcinogenic criteria. The current research indicates that S. jamaicensis compounds can be used as an inhibitor for Cat L and as a COVID-19 drug candidate.
Alterations in Blaood Profiles and Spleen Tissue Following Purple Sweet Pota-to Anthocyanin Extract Treatment in Restraint-Stressed Mice: Blood Profiles and Spleen Tissue Following Purple Sweet Potato Anthocyanin Extract Treatment Kurnianingsih, Nia; Artamevia, Dian; Hasanah, Dian; Harbiyanti, Novita Titis; Ratnawati, Retty
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.19

Abstract

Stress is associated with broad changes in blood and immune cell dysfunction, which are correlated with the spleen as a secondary lymphoid organ. Anthocyanin, a plant bioactive compound from purple sweet potatoes, has previously been reported to have a beneficial effect on stress response behavior. However, the limited studies evaluated anthocyanin's effect on blood profiles and spleen tissue under stress. Therefore, this study aimed to explore the effect of total anthocyanin extract (ANC) from purple sweet potatoes (PSP) on the blood profiles and spleen tissue of restraint stressed mice. A total of 20 male adult BALB/c mice were divided into control (CTRL), stress (STR), stress + ANC 10 mg/kgBW (STR+ANC10), stress + ANC 20 mg/kgBW (STR+ANC20), and stress + ANC 40 mg/kgBW (STR+ANC10). Restraint stress was applied two hours/day for 14 days. An automatic blood analyzer was used for blood profiling. Immunoblotting of caspase-3 and hematoxylin-eosin-stained histological slides were observed for spleen tissue analysis. Combination of STR and ANC treatment reduced the erythrocyte count, hemoglobin level, and leucocyte count. The ANC-treated groups had a higher percentage of lymphocytes and a lower percentage of granulocytes. The expression of caspase-3 declined among ANC-treated groups. Spleen extramedullary erythropoiesis, vacuolization, and white pulp involution were demonstrated in stress and ANC-treated animals. In summary, restraint stress modified the blood cell profiles and spleen tissue in the mice model. Further research is necessary to evaluate the mechanism of ANC during stress on blood cells and splenic tissue repair enhancement.
Screening of Potential Compounds in Tomato (Solanum lycopersicum) as Candidates for Anti Diabetes Mellitus Complications Narwasthu, Sekararum; Fahmi, Muhamad; Kurnianingsih, Nia; Wihastuti, Titin Andri; Fatchiyah, Fatchiyah
Indonesian Journal of Chemistry Vol 24, No 4 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.93505

Abstract

This study aimed to identify the potential of natural compounds in tomatoes for diabetic complications intervention using amino acid profile, HP-TLC, antioxidant assay, enzymatic inhibitor assay, and in silico approach. Fresh air-dried tomatoes were analyzed for several screening assays including amino acid determination, HP-TLC, antioxidant activity using FRAP, α-amylase, and α-glucosidase enzyme inhibition. Virtual screening, molecular docking and molecular dynamics were performed using Molinspiration, pKcSM, AutoDock Vina, Discovery Studio, PyMOL, and Yasara software. Tomato bioactive compounds showed promising drug-likeness, antioxidant and α-amylase/glucosidase inhibitory activities, and potential for AGE-RAGE interaction. Out of 19 compounds from whole tomatoes complying with Lipinski’s rule of five, genistein, apigenin, and naringenin exhibited high oral absorption potential. Tomato contains genistein compound based on HP-TLC and the compound has high antioxidant and antidiabetic activities. Genistein has a stronger binding affinity with RAGE compared to AGE, indicating its potential as a competitive inhibitor. Additionally, genistein displayed stable ligand movements and higher binding energy values in MD simulations compared to the control. These findings suggest the potential of tomato bioactive compounds for further development as antidiabetic agents targeting AGE-RAGE interaction. In conclusion, genistein in tomatoes is indicated as a candidate for anti-complications of diabetes mellitus. 
HUBUNGAN TINGKAT STRES DENGAN DERAJAT KEPARAHAN SINDROMA PRAMENSTRUASI MAHASISWI TINGKAT AKHIR SARJANA KEBIDANAN FAKULTAS KEDOKTERAN UNIVERSITAS BRAWIJAYA DI MASA PANDEMI COVID-19 Maulidya, Ajeng Khamara; Gumanti, Kentri Anggarina; Kurnianingsih, Nia
Majalah Kesehatan Vol. 11 No. 4 (2024): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2024.011.04.4

Abstract

Pandemi Corona Virus Diseases-19 (COVID-19) memberikan perubahan yang signifikan bagi dunia pendidikan termasuk pembelajaran di perguruan tinggi. Penyesuaian strategi pembelajaran baru memberikan tekanan stres bagi mahasiswa. Dampak tersebut sangat bermakna pada mahasiswa kesehatan di tahun terakhir. Stres dapat berpengaruh terhadap timbulnya sindrom pramenstruasi berupa sejumlah gejala fisik dan psikis mengganggu yang muncul sebelum dan selama menstruasi. Penelitian ini bertujuan untuk mengetahui hubungan tingkat stres dengan derajat keparahan sindrom pramenstruasi pada mahasiswi tingkat akhir Program Studi Sarjana Kebidanan Fakultas Kedokteran Universitas Brawijaya di masa pandemi COVID-19. Penelitian ini merupakan penelitian observasional analitik dengan desain cross-sectional. Sejumlah 72 responden dari mahasiswa yang terdaftar di tingkat akhir Program Studi Sarjana Kebidanan Fakultas Kedokteran Universitas Brawijaya, mengisi kuesioner yang terdiri dari data sosiodemografi, instrumen Perceived Stress Scale (PSS) dan Shortened Premenstrual Assesment Form (SPAF). Statistik deskriptif dilakukan untuk analisis data sosiodemografi, klasifikasi derajat stres dan sindrom pramenstruasi. Uji Korelasi rank Spearman digunakan untuk analisis hubungan kedua variabel. Sejumlah 66,7% responden berada dalam kategori stres sedang. Sindrom pramenstruasi derajat berat dialami oleh 50% responden. Tingkat stres berhubungan dengan derajat keparahan sindrom pramenstruasi (p = 0,000, r = 0,698). Hal ini menunjukkan bahwa semakin tinggi tingkat stres maka tingkat gejala sindrom pramenstruasi yang dialami menjadi semakin berat.
CRANIOFACIAL ANTHROPOMETRY CHARACTERISTIC AND DERMATOGLYPHICS PATTERN AMONG SCHIZOPHRENIA SUBJECTS IN JAVANESE ETHNIC OF INDONESIA Cahayani, Wike Astrid; Adiba, Rizqi Hasna; ‘Aisy, Nabilah Rohadatul; Widyanto, Ilham Aditya; Sunardi, Adisty Aulia Kamarani; Ramadhan, Yanuar; Yudhantara, Dearisa Surya; Kurnianingsih, Nia
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.01

Abstract

Background: Craniofacial dysmorphology and dermatoglyphic abnormalities in schizophrenia patients are hypothesized to reflect neurodevelopmental disturbances during embryogenesis. These markers may serve as cost-effective, non-invasive tools for identifying individuals at risk of schizophrenia. Objective: This study aimed to explore craniofacial anthropometry and dermatoglyphic profiles as potential early markers of schizophrenia in the Javanese ethnic population. Methods: A cross-sectional study was conducted involving 30 schizophrenia patients and 30 matched healthy controls. Craniofacial measurements (cephalic, facial, and nasal indices) were obtained, and fingerprint patterns were analyzed for dermatoglyphic traits. Statistical comparisons employed unpaired T-tests and Mann-Whitney tests. Results: Significant differences were observed in facial index (P<0.01) and nasal index (P<0.05) between schizophrenia and control groups, with hyperleptoprosopic facial types dominating in schizophrenia patients (56.7%). Dermatoglyphic analysis showed no significant differences; however, a higher prevalence of loop patterns and reduced whorl patterns were noted in the schizophrenia group. Conclusion: Craniofacial anthropometry demonstrates promising potential as an adjunctive marker for early schizophrenia risk detection, particularly in resource-limited settings where advanced diagnostic tools are unavailable. Although dermatoglyphic patterns revealed limited statistical significance, observed trends highlight the need for further studies. These findings provide a basis for developing population-specific screening programs and contribute to the understanding of ethnic-specific neurodevelopmental markers.
Anticancer Potential of Cyanidin and Cyanidin-3-Glucoside Through TrkB Receptor Inhibition: Evidence From Molecular Interaction Docking Kurnianingsih, Nia; Suprapto, Ratih Paramita; Ratnawati, Retty
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 5 No. 2 (2024): JSMARTech Volume 5, No. 2, 2024
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2024.005.02.41

Abstract

Cancer remains a global health problem with persisten demand on therapeutic development to inhibit cancer cells growth without harmful effects on healthy cells. Plant bioactive compounds are intensively studied as anticancer via several signalling pathway. Anticancer therapy via inhibition of tropomyosin kinase receptor-B (TrkB) signal was previously proposed as target therapy. The role of plant metabolites cyanidin and cyanidin-3-glucoside as TrkB inhibitor is has not been investigated. This study was aimed to identify physicochemical of cyanidin and cyanidin-3-glucoside as well as determine it’s role towards TrkB receptor signalling pathway through in silico approach. Molecular docking was performed using Hex 8.0.0 software and visualizes using Discovery Studio Visualizer. The energy binding of TrkB with cyanidin and cyanidin-3-glucoside was -263,21 kcal/mol and 281,65 kcal/mol respectively. Complex of cyanidin-3-glucoside had hydrogen and hydrophobic bond more than TrkB-cyanidin complex. The hydrogen bond formed at Lys637, Arg558 and Gly 561 amino residues. Physicochemical analysis demonstrated that both ligand are potential as kinase enzyme inhibitor. Cyanidin-3-glucoside was predicted more potential as anticancer than cyanidin via TrkB receptor inhibition. Future studies are required to confirm current finding both in-vitro and in-vivo models.
DEPRESSION AND INTERNET GAMING DISORDER AMONG MEDICAL STUDENT IN MALANG, INDONESIA Kurnianingsih, Nia; Cahayani, Wike Astrid; Yudhantara, Dearisa Surya; Ratnawati, Retty
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.08

Abstract

Background: Medical education is widely regarded as a highly demanding curriculum that causes significant stress among students. Chronis stress generates depression and increase of internet gaming activity. Previous research examined the relationship between the length of time spent for internet gaming activity as well as grade point average (GPA) towards internet gaming disorder (IGD) among medical student in Malang Indonesia. The limited data on the frequency of depression and the association between depression with IGD among medical students calls for more research. Objectives: This study was purposed to analyse the prevalence of depression as well as its association with IGD among medical students in Malang, Indonesia. Methods: This descriptive and cross-sectional study involved 437 medical students who completed a set of self-report questionnaires. The questionnaires included sociodemographic data, Beck Depression Inventory (BDI) scale and Personal Internet Gaming Disorder-9 (PIE-). Descriptive and bivariate analyses were employed for statistical analysis. Results: Depression was identified among 37.99% students, with female being more likely to suffer from it. There were 59.64%, 34.94% and 5.42% correspondingly of students with mild, moderate, and severe depression. The rate of depression was highest among 1st year students. Poor GPA achievement was observed in 50.98% of students with depression. Students without internal motivation were more likely to have depression (57.14%). Surprisingly, depression was not linked associated with IGD (p=0.06). Conclusion: This study concluded a high prevalence of depression among medical students with various sociodemographic characteristics. Despite depression had no association with IGD, future research is necessary for evaluate the potential risk factor of depression among medical students.
Anthocyanin-Rich Extract from Purple Sweet Potatoes Modified Body Weight, Visceral Fat and Circulatory IL-10 in Stressed-Mice Kurnianingsih, Nia; Rahma, Oktivani Adelathifa; Prayogo, Nabila Putri; Rayhanna, Qanitha Ailsya; Fahanani, Agwin Fahmi; Suprapto, Ratih Paramita; Prakosa, Ardani Galih; Ratnawati, Retty
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Abstract

Stress-induced inflammation and oxidative stress mechanisms thus plant bioactive compounds as anti-inflammation and antioxidants are placed as novel strategies to resist the adverse effects of stress. Purple sweet potatoes (PSP) as a rich source of macronutrients and anthocyanin showed health benefits as neuroprotective and metabolic diseases. However, limited research explored the effect of PSP extract on stressed animal models. This study aimed to evaluate the bioactive compound analysis of PSP and the effect on body weight gain (BW), visceral fat (VF), and interleukin-10 (IL-10) of stressed model mice. Adult male BALB/c mice (6-8 weeks) were divided into control (CTRL), and stress (STR), stress+anthocyanin-rich extract (ANC) of PSP dose 10, 20, and 40 mg/kgBW. Stress was exposed as restraint stress for 2 hours/day for 14 days. The ANC was administered once a day orally. The IL-10 was measured by enzyme-linked immunosorbent assay (ELISA). Qualitative plant compound analysis showed the presence of flavonoids, alkaloids, phenolics, glycosides, and tannins in PSP extract. The PSP extract also contains a high level of total anthocyanin, 2468.9 ± 159.38 mg/l, and high antioxidant activity. This study observed tendencies to decrease BW and VF following ANC dose of 10 mg/kgBW treatment. The administration of ANC significantly increased the level of circulatory IL-10 cytokine. In conclusion, an anthocyanin-rich extract of PSP modified BW, VF, and IL-10 levels of restraint-stressed model mice.
Phytochemical Analysis of Purple Sweet Potatoes (Ipomoea batatas) Roots Extract From Lawang and Kawi Mountain Cultivar, East Java, Indonesia Alam, Fajar Mustika; Kurnianingsih, Nia; Fatchiyah, Fatchiyah
The Journal of Experimental Life Science Vol. 12 No. 1 (2022)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2022.012.01.03

Abstract

Indonesia has wide cultivation of purple sweet potatoes (PSP) commodities, particularly in East Java province. However, the difference of phytochemical profiles in PSP among geographical regions has not been fully explored. This study aimed to analyze the phytochemicals, anthocyanin, and antioxidant activity profiles from two different cultivars of PSP from Lawang and Kawi Mountain region, East Java, Indonesia. The acidified methanol extract was identified for a phytochemical compound using standard methods. Antioxidant activity was analyzed using a ferric reducing assay. Anthocyanins were screened using ultraviolet-visible spectroscopy and total calculation. Both extracts have positive values in their alkaloid, phenolic, flavonoid, glycoside, and tannin content. Antioxidant activity was high with IC50 value 2.5 and 2.3 µg. mL-1 for Lawang and Kawi Mountain, respectively. Each cultivar has a similar peak at 521 nm at pH 1 and 530 nm at pH 4.5. Total anthocyanin calculation was showed that Lawang has higher anthocyanin content than Kawi Mountain cultivar. We concluded that PSP from Lawang has better anthocyanin content than the Kawi Mountain cultivar. We proposed that PSP from the Lawang cultivar has the potential to be explored in further research and health-related product development.
Impact of walking exercise intensity on cartilage IL-1, TNF-α, IL-4, MMP-13 and pain threshold in osteoarthritis rat models Handono, Kusworini; Prasetyo, Dwi A.; Kurnianingsih, Nia; Wahono, Cesarius S.; Albaar, Thoha M.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.2109

Abstract

Pro-inflammatory cytokines produced by chondrocytes play a crucial role in activating matrix metalloproteinase-13 (MMP-13), leading to an imbalance between the synthesis and degradation of the extracellular matrix (ECM) in osteoarthritis (OA). Although regular walking exercise has been shown to reduce inflammatory cytokine levels in OA animal models, the optimal exercise intensity remains underexplored. Therefore, the aim of this study was to investigate the effects of different intensities of regular walking exercise on the levels of pro-inflammatory cytokines (interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α)), anti-inflammatory cytokine (interleukin-4 (IL-4)), as well as MMP-13 expression in cartilage and pain thresholds in an OA animal model. A total of 30 adult male Rattus norvegicus (6–8 weeks old) were divided into five groups: (1) healthy control; (2) monosodium iodoacetate (MIA)-induce OA model; (3) OA with light-intensity walking (OA1); (4) OA with moderate-intensity walking (OA2); (5) and OA with high-intensity walking (OA3). The exercise intervention began one week after MIA injection and continued for six weeks. Pain threshold, inflammatory cytokine (IL-1, TNF-α, IL-4) levels, and MMP-13 expression were measured using an analgesymeter, enzyme-linked immunosorbent assay (ELISA), and immunohistochemistry (IHC), respectively. The results demonstrated a significant reduction in IL-1 and TNF-α levels, along with decreased MMP-13 expression and increased IL-4 levels, in all exercise groups (OA1, OA2, OA3) compared to the untreated OA group. Additionally, pain thresholds improved following exercise. However, no significant differences were observed among the three exercise intensities in terms of cytokine levels, MMP-13 expression, or pain threshold. This study highlights that the light-intensity regular walking exercise effectively reduces inflammation, MMP-13 expression, and pain in OA. Further research is needed to elucidate the underlying mechanisms of exercise in OA management.
Co-Authors Adiba, Rizqi Hasna Alam, Fajar Mustika Albaar, Thoha M. Ardani Galih Prakosa, Ardani Galih Arief Fadillah Artamevia, Dian Cahayani, Wike Astrid Dian Hasanah Fahanani, Agwin Fahmi Fahmi, Muhamad fatchiyah . Gumanti, Kentri Anggarina Hafifah Rahmi Puspitaningsih Harbiyanti, Novita Titis Kusworini Handono Maulidya, Ajeng Khamara Mega, Hadistia Muhammad Reza Faisal, Muhammad Reza Narwasthu, Sekararum Prasetyo, Dwi A. Prayogo, Nabila Putri Rahma, Oktivani Adelathifa Rahmi Puspitaningsih, Hafifah Ramadhan, Yanuar Rayhanna, Qanitha Ailsya Retty Ratnawati Sunardi, Adisty Aulia Kamarani Suprapto, Ratih Paramita Titin Andri Wihastuti Utami, Juliyatin Putri Wahono, Cesarius S. Widyanto, Ilham Aditya Yudhantara, Dearisa Surya ‘Aisy, Nabilah Rohadatul