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All Journal International Journal of Health, Economics, and Social Sciences (IJHESS) Jurnal Kolaboratif Sains
Sri Murtiningrum
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Internal Quality Control on Leukocyte Count at UPTD Health Laboratory, Sleman, DIY Prasetya, Hieronymus Rayi; Nurlaili Farida Muhajir; Seprianto Maloko; Sri Murtiningrum
International Journal of Health, Economics, and Social Sciences (IJHESS) Vol. 6 No. 3: July 2024
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/ijhess.v6i3.5744

Abstract

Background: Hematology analyzers (HA) are used for automated leukocyte counts, but are subject to errors if nucleated erythrocytes, fibrin precipitation, or prolonged sample sitting are present. Quality control is required to ensure accuracy of results. The clinical laboratory of the UPTD Health Laboratory of Sleman Regency, DIY has carried out quality control but has not involved Levey-Jennings control charts and six sigma analysis. This study aims to determine the internal quality assurance of the analytical stage of the HA device in the examination of leukocyte counts in that laboratory. Methods: This type of research is a descriptive study with the subject of the HA Sysmex XP-100 tool. The variables of this study are data from the quality control results of automatic leukocyte count examination in February-March 2024. Data analysis includes calculation of six sigma values, creation of Levey-Jennings control charts and evaluation using westgard rules. Results: The results showed that the examination of the number of leukocytes with the HA tool had an accuracy of 99.45% and a precision of 98.49%, while for the evaluation of the Levey-Jennings graph with the westgard rule at the normal level control, there was a rule of 12s on day 3 and 13s on day 6. Six sigma analysis shows that the performance of the tool for examining the number of leukocytes is at world class level with an average sigma value of 12.42. Conclusion: This Based on the results, it can be concluded that the examination of leukocyte counts with the HA Sysmex XP-100 at the Sleman Regency Health Laboratory UPTD, DIY has an accuracy of 99.45% and a precision of 98.49%. Evaluation of the Levey-Jennings control chart and Six Sigma analysis showed world-class performance, indicating that this tool provides excellent performance and meets international quality standards.
Leukositosis pada Pasien Skizofrenia yang Mendapat Terapi Obat Antipsikotik : Leukocytosis in Schizophrenia Patients Receiving Antipsychotic Drug Therapy Hieronymus Rayi Prasetya; Arum Nuryati; Sri Murtiningrum; Rizky Windi Ramadhani
Jurnal Kolaboratif Sains Vol. 7 No. 2: FEBRUARI 2024
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.852 KB) | DOI: 10.56338/jks.v2i1.667

Abstract

Latar Belakang : Skizofrenia adalah gangguan pikiran yang disebabkan hiperaktivitas dopaminergik yang ditandai dengan ketidakmampuan berpikir, emosi dan tingkah laku. Tata laksana pengobatan skizofrenia ialah pemberian obat antipsikotik salah satunya Clozapine. Clozapine mampu bekerja dengan menyeimbangkan zat alami kimia otak dengan cara memblokir reseptor dopamin, histamin, dan serotonin Namun, Clozapine juga memiliki efek samping diantaranya dapat terjadinya leukopenia ataupun leukositosis. Tujuan penelitian ini untuk mengetahui jumlah leukosit pada pasien skizofrenia yang mendapat terapi obat antipsikotik di RSJ Prof. Dr. Soerojo Magelang. Metode : Penelitian ini menggunakan metode deskriptif kualitatif, bertujuan untuk mengetahui gambaran jumlah leukosit pada pasien skizofrenia yang mendapat terapi obat antipsikotik. Sampel pada penelitian ini adalah seluruh pasien dengan diagnosis skizofrenia yang dirawat di RSJ Prof. Dr. Soerojo Magelang pada bulan Januari – Desember 2022 sejumlah 398 pasien. Hasil : Dari hasil analisa pasien yang mengalami leukopenia berdasarkan kombinasi obat yaitu pada kombinasi 2 obat (0,25%) dan kombinasi 3 obat terdapat (0,25%). Pasien yang mempunyai jumlah leukosit normal pada obat tunggal (0,50%), kombinasi 2 obat (2,26%), kombinasi 3 obat (7,80%), kombinasi 4 obat (30,40%), kombinasi 5 obat (33,92%), dan kombinasi 6 obat (1,01%). Pasien yang mengalami leukositosis pada obat tunggal (0,25%), kombinasi 2 obat (0,25%), kombinasi 3 obat (4,02%), kombinasi 4 obat (8,04%), kombinasi 5 obat (10,55%) dan kombinasi 6 obat (0,50%). Kesimpulan : Pasien yang mengalami leukopenia berjumlah 2 orang (0,50%) dengan rata-rata 3.400 sel/µl, pasien dengan jumlah leukosit normal berjumlah 302 orang (75,5%) dengan rata-rata 8.558 sel/µl dan pasien yang mengalami leukositosis berjumlah 94 orang (24%) dengan rata-rata 13.328 sel/µl.
Co-Authors Arum Nuryati Hieronymus Rayi Prasetya Hieronymus Rayi Prasetya, Hieronymus Rayi Nurlaili Farida Muhajir Rizky Windi Ramadhani Seprianto Maloko