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All Journal Jurnal Biomedika dan Kesehatan Journal of Clinical Microbiology and Infectious Diseases
Abas, Ghina Mutiara
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Rickettsia as an agent of neglected Rickettsia infection Tjampakasari, Conny Riana; Kiranasari, Ariyani; Abas, Ghina Mutiara
Journal of Clinical Microbiology and Infectious Diseases Vol. 4 No. 1 (2024): Available online: June 2024
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v4i1.42

Abstract

Rickettsia is an obligate parasite of certain arthropods (especially ticks, mites, and ticks) and can cause serious diseases. OmpA dan OmpB is a surface protein that facilitates Rickettsia’s fast attachment and entry into the endothelium. Clinical symptoms are usually characterized by self-limited acute fever in both humans and other animals. Diseases caused by Rickettsia are endemic in almost all around the world, including Indonesia. Rickettsia diseases include epidemic typhus, murine typhus, scrub typhus, and spotted fever. Culture, nucleic acid amplification, and serological tests can be used as diagnostic examinations. The serological test is the gold standard of Rickettsial diagnostic, even though molecular tests have been developed. Diagnostic limitations mean that rickettsiosis is often overlooked as a cause of infection. Rickettsia eradication was carried out by giving tetracycline, chloramphenicol, and rifampin. Vaccines are not yet available so prevention and appropriate use of antibiotics based on the diagnostic examination will determine the success of eradication.
Risiko Reaktivasi Tuberkulosis Laten pada Terapi COVID-19 Abas, Ghina Mutiara; Sjatha, Fithriyah; Rosana, Yeva
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.363-372

Abstract

The high mortality rate among COVID-19 patients in the acute respiratory distress syndrome (ARDS) phase led to the administration of immunosuppressive drugs. Corticosteroids could block inflammation caused by cytokine storm, and prevent pneumonia, edema, fibrosis, and ARDS. Even though it was believed to have beneficial effects, corticosteroids can suppress T CD4+ and CD8+ cell-mediated immunity reaction through decreased IFNγ production thus leading to reactivation of latent Tuberculosis (LTBI). Therefore, the usage of corticosteroids in the ARDS phase of COVID-19 patients should be carefully given; pre-screening of LTBI may be done to avoid Tuberculosis reactivation.
Co-Authors Ariyani Kiranasari SJATHA, FITHRIYAH Tjampakasari, Conny Riana Yeva Rosana