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All Journal Journal of Multidisciplinary Science: MIKAILALSYS Asian Journal of Science, Technology, Engineering, and Art
Tansaba, Akafa Andes
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Agriculture, Biological Sciences & Forestry Arts Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Engineering Environmental Science Physics Social Sciences Other

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Antidiabetic Potential of Khaya Anthotheca Methanolic Leaves Extract in Streptozotocin Diabetes Induced Rats Umaru, Kerenhappuch Isaac; Tansaba, Akafa Andes; Umaru, Isaac John; Ugoeze, Egeonu Stephen; Nanmar, Chakfa; David, Bando Christopher
Journal of Multidisciplinary Science: MIKAILALSYS Vol 2 No 2 (2024): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v2i2.3191

Abstract

This research evaluated antidibetic potential of methanolic leaves extracts of Khaya anthotheca in streptozotocin induced albino rats. Khaya anthotheca a member of Meliaceae family is traditionally used for treating several ailments. Diabetes is a chronic condition that develops when the pancreas is unable to secrete sufficient amounts of insulin or when the body fails to utilise the insulin that is produced. The leaves were harvested in Sukundi road Wukari and air dried for four weeks, the leaves were pulverized into powder using manual blender and stored in an air tight container. Extraction was done with absolute methanol; the extract was filtered using mesh and the filtrate was concentrated at 68oC. two grams of the filtrate were used for the study; the remainder was used to treat the animals. Using 40 mg/kg body weight of streptozotocin, the animals were divided into 5 groups of 4 each. Following a fourteen-day course of treatment, the animals were sacrificed; the blood was drawn through heart puncture and tested for blood sugar using a glucometer. One-way analysis of variance (ANOVA) was used for statistical analysis. Result of blood sugar level showed significant reduction in all the test groups (p<0.05) except group 2 which showed no significant reduction when compared to the normal control. Conclusion: This study therefore suggests the use of Khaya anthotheca as a diabetic agent and for treatment of diabetes. Further studies are needed to discover the bioactive constituent of the plant responsible for this anti-diabetic activity as well as other pharmacological activities in clinical trials.
Assessment of Hyperglycemic Potentials of Khaya Anthotheca Stem-Bark Extracts on Alloxan-Induced Diabetic Rats Umaru, Kerenhappuch Isaac; Nanmar, Chakfa; Umaru, Isaac John; Ugoeze, Egeonu Stephen; Tansaba, Akafa Andes; David, Bando Christopher
Asian Journal of Science, Technology, Engineering, and Art Vol 2 No 3 (2024): Asian Journal of Science, Technology, Engineering, and Art
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstea.v2i3.3183

Abstract

Introduction: Medicinal plants have been the basis of treatment of various diseases in African traditional medicine as well as other forms of treatment from diverse cultures of the world. Khaya anthotheca is a member of the family Meliaceae, a native to Africa. It is a medicinal plant widely used for several therapeutic purposes. Herein, phytochemical study, hyperglycaemic investigations was carried out on the methanol extract of Khaya anthotheca Stem-bark. Materials and Methods: However, 35 rats were distributed into seven groups to evaluate the anti-diabetic activity of K. anthotheca stem-bark methanol extract at the dosage range of 50-400 mg/kg/b.wt. The analysis was done using the software-SPSS one-way ANOVA at a significance level p<0.05. Results: The result of the anti-diabetic study reveals that extract elicited substantial (p<0.05) inhibition of hyperglycaemic. The plant Khaya anthotheca stem-bark methanol extract displayed profound (p<0.05) anti-hyperglycaemic action at the dosage of 200 mg/kg/b.wt, 300 mg/kg/b.wt. and 500 mg/kg/b.wt. against induced diabetic rats. Conclusion: This study therefore suggests the use of Khaya anthotheca as a hypoglycaemic agent and for treatment of diabetic. Further studies are needed to discover the bioactive constituent of the plant responsible for this anti-diabetic activity.
Phytochemical Profiling, and Antifungal Potentials of Stem-Bark Extracts of East African (Khaya Anthotheca) Umaru, Kerenhappuch Isaac; Ugoeze, Egeonu Stephen; Umaru, Isaac John; Nanmar, Chakfa; Tansaba, Akafa Andes; David, Bando Christopher
Asian Journal of Science, Technology, Engineering, and Art Vol 2 No 3 (2024): Asian Journal of Science, Technology, Engineering, and Art
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstea.v2i3.3185

Abstract

Fungal infection is an infectious disease that is commonly implicated as aetiologic agents that contribute to the increasing burden of morbidity and mortality in developing countries as a result misdiagnosis or improper diagnosis. This study determined the profiling and antifungal potentials of Stem-Bark Extracts of East African (Khaya Anthotheca). The methanol solvent was used for disc diffusion assay. The inhibitory concentration of the extract was performed by broth dilution method and zone of inhibition was studied by disc diffusion method at the concentration of 50, 100, 250, and 500 in DMSO. Nystatin was used as the reference control for antifungal study. The extract showed maximum inhibition potential sof zone of inhibition against most of the pathogen (Aspergillus niger, Aspergillus flavus, Candida tropicalis and Fusarium oxysporium) used at concentration 50ppm to 500ppm. The zone of inhibition for 500ppm is shown as (319.12± 0.11, 19.23 ± 0.12, 20.33±0.23* and 18.34±0.21*mm respectively). The extract showed minimum inhibition potential against Aspergillus flavus in all the concentration when compared with the control as well as to the other pathogens. Candida tropicalis and Fusarium oxysporium was found to be more sensitive to the methanol extract followed by Aspergillus flavus and Aspergillus niger lastly. The extract was found to be rich in phytochemical, with about 20 different chemical constitutes, with 12.14- Pentane, 3-ethyl-2,4-dimethyl-, 14.66-3-Hexen-2-one and 27.23-2-Nonenal, 2-pentyl-as the highest. The Present study indicates the potential usefulness of methanol extract of extract of khaya anthotheca as antifungal agent. Thus, has therefore, contributed to the pool of knowledge already available in this area of research. Considering the effects that both phytochemicals and its potentials as antifungal, it would be expedient to conduct further studies to assess its cancer potentials.
Co-Authors David, Bando Christopher Nanmar, Chakfa Ugoeze, Egeonu Stephen Umaru, Isaac John Umaru, Kerenhappuch Isaac