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All Journal JC-T (Journal Cis-Trans): Jurnal Kimia dan Terapannya Influence: International Journal of Science Review
Fajriyah, Maulida
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Engineering Environmental Science Materials Science & Nanotechnology Public Health Social Sciences

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Nanometer-Scale Drug Synthesis: Innovations in Pharmaceutical Nanotechnology Fajriyah, Maulida; Nurjannah, Neng Rita; Ambardhani, Nurul; Jannah, Nanda Raudhatil
INFLUENCE: INTERNATIONAL JOURNAL OF SCIENCE REVIEW Vol. 6 No. 1 (2024): INFLUENCE: International Journal of Science Review
Publisher : Global Writing Academica Researching and Publishing

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Abstract

Nanometer-scale drug development represents a new era in pharmaceutical technology, promising significant improvements in the efficacy and safety of treatments. Nanotechnology innovations in drug synthesis offer the potential to address existing global health challenges, including drug resistance and difficult-to-treat chronic diseases. However, the synthesis process at the nanometer scale faces significant obstacles, including biocompatibility issues, unclear regulations, and technical challenges in production. This research aims to explore and identify strategies to overcome these challenges, as well as assess the potential of nanotechnology innovation in the development of new drugs. The research method used is a descriptive qualitative approach, with data sourced from relevant previous literature. The data collected is then processed to gain an in-depth understanding of the research subject. The conclusions of this study indicate that although the challenges in nanometer-scale drug synthesis are significant, the potential for nanotechnology innovation in pharmaceuticals is revolutionary. Effective strategies to overcome these challenges include the development of new synthesis methods, advances in characterization techniques, and close interdisciplinary collaboration. Policies and regulations that support innovation are urgently needed to facilitate the development and implementation of these new medicines. Finally, the future of nanometer-scale medicine depends on increasing access and desirability, taking into account ethics and safety in product development.
Modifikasi Screen Printed Carbon Electrode Menggunakan Cerium dan Optimasi Kondisi Percobaan Biosensor Elektrokimia untuk Deteksi DNA Mitokondria Sus Scrofa Fajriyah, Maulida; Hartati, Yenni Wahyuni; Anggraeni, Anni; Gaffar, Shabarni
JC-T (Journal Cis-Trans): Jurnal Kimia dan Terapannya Vol 6, No 1 (2022)
Publisher : State University of Malang or Universitas Negeri Malang (UM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.918 KB) | DOI: 10.17977/um0260v6i12022p032

Abstract

Penggunaan cerium dalam aplikasi sensor telah banyak dikembangkan. Dalam penelitian ini, biosensor elektrokimia telah dikembangkan untuk mendeteksi DNA mitokondria Sus scrofa menggunakan screen printed carbon elektrode-cerium (SPCE-Ce). Permukaan elektrode SPCE sebelum dan sesudah dimodifikasi dengan cerium dikarakterisasi menggunakan Scanning Electron Microscopy (SEM) dan voltammetri siklik (CV). Desain urutan nukleotida babi sebagai DNA probe, ditentukan dengan menggunakan program NCBI blast dan T-Coffee. DNA probe diamobilisasikan pada SPCE-Ce melalui interaksi elektrostatik antara permukaan cerium dengan tulang punggung fosfat dari DNA. Selanjutnya proses hibridisasi DNA probe - target dikarakterisasi menggunakan voltammetri diferensiasi pulsa (DPV). Permukaan SPCE dan SPCE-Ce secara SEM menunjukkan perbedaan morfologi yaitu permukaan yang lebih halus dan rata setelah permukaan karbon tertutupi cerium. Voltammogram siklik menunjukkan adanya kenaikan puncak arus redoks dari spesi elektroaktif ferisianida pada SPCE-Ce. Urutan DNA probe adalah 5’-TATTIATACCAATCACTAIC-3’ yang memiliki homologi 100% dengan DNA babi dan homologi 0% dengan DNA ayam dan sapi. Persamaan linier konsentrasi target terhadap arus menghasilkan persamaan I = 0,0303 [target] + 3,947 untuk rentang konsentrasi DNA target 5,0 sampai 30,0 µg/mL, dan nilai LoD adalah 1,44 µg/mL. Biosensor ini selanjutnya dapat digunakan untuk penentuan konsentrasi mtDNA babi dalam sampel.
Co-Authors Ambardhani, Nurul Anni Anggraeni, Anni Nanda Raudhatil Jannah Nurjannah, Neng Rita Shabarni Gaffar -, Shabarni Gaffar Yenni Wahyuni Hartati, Yenni Wahyuni