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All Journal Indonesian Journal of Global Health research The Journal of Society Medicine (JSOCMED) Media Dermato-Venereologica Indonesiana
Astarina, Awalia
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Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Generalized Exfoliative Dermatitis Suspected Caused by COVID-19 Vaccine : A Case Report Hazlianda, Cut Putri; Dalimunthe, Dina Arwina; Astarina, Awalia
Journal of Society Medicine Vol. 2 No. 12 (2023): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i12.109

Abstract

Introduction: Exfoliative dermatitis (ED) is a skin disorder characterized by the presence of erythema and scaling of the skin involving more than 90% of the total body surface area. One of the main etiologic factor of ED is drug hypersensitivity reaction. Vaccine administration can result in allergic reactions. The aim of this case report is to provide information on one of the forms of allergy to the COVID-19 vaccine, which can be ED. Case: A woman, 61 years old, with complaints of reddish patches accompanied by thickened scales and spread throughout the body accompanied by itching, pain in the skin, experiencing fatigue and chills since 3 days ago before the patient said she had received COVID-19 booster vaccine. The patient was diagnosed with generalised exfoliative dermatitis suspected to be caused by the COVID-19 vaccine. The patient was given therapy with oral methylprednisolone 36 mg/day with tapering if there was improvement, and topical urea 10% cream and hydrocortisone 2.5 % cream (face) and desoxymethasone 0.25 % cream (body). Discussion: ED is more common in men than women, with the highest incidence at the age of 40-60 years. The underlying therapy of ED is to address the aetiology and potential complications. The therapy was corticosteroids at a dose of 1-2 mg/kg/day with tapering, emollients and topical corticosteroids. The patient was given these therapies, showed clinical improvement within 5 weeks of treatment and no side effects. Conclusion: Exfoliative dermatitis can be idiopathic or secondary to drug hypersensitivity including vaccine administration. A complete history including history of drug administration and a thorough physical examination are required so that treatment can be given appropriately.
Clinical Features and Histopathologic Examination in Supporting The Diagnosis of Exfoliative Dermatitis Suspected Caused by Captopril in Child : A case report Astarina, Awalia; Alferraly, T Ibnu; Paramita, Deryne Anggia; Nababan, Kristo A
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6870

Abstract

Exfoliative dermatitis (ED) is defined as diffuse erythema and scaling of the skin involving more than 90% of the total body skin surface area. It is a reaction pattern and cutaneous manifestation of a myriad of underlying ailments, including psoriasis and eczema, or a reaction to the consumption of certain drugs. Though some experts believe it does not pose a significant risk of death, erythroderma is a potentially life-threatening condition that requires proper diagnosis, identification of underlying etiology, and management. Several factors have been implicated as triggers for erythroderma and can be grouped into several general categories, including preexisting dermatoses, drugs, and malignancies. Drugs Involved in ED, one of the drugs that cause it is cardiac drugs such as captopril. Captopril, an angiotensin-converting enzyme (ACE) inhibitors containing a sulfhydryl group and has occasionally been implicated in complex immunological diseases, this chemical group has been considered the culprit of allergic reactions to captopril. Histopathologic examination is important to exclude differential diagnosis. Management of ED involves combining symptomatic relief with addressing the underlying etiology and potential systemic complications. In patient hospitalization is required in acute cases.
Klinikopatologi Pemfigus Vulgaris dan Pengukuran Aktivitas Penyakit Pemphigus dengan Pemphigus Disease Area Index astarina, awalia; A Nababan, Kristo
Media Dermato-Venereologica Indonesiana Vol 53 No 1 (2026): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v53i1.547

Abstract

   Pendahuluan: Pemfigus vulgaris (PV) adalah penyakit autoimun yang ditandai dengan lepuh kendur dan erosi, yang tidak hanya melibatkan kulit, tetapi juga pada mukosa. Pemeriksaan histopatologis dapat membantu penegakan diagnosis. Penentuan lokasi biopsi kulit merupakan hal yang penting dalam pemeriksaan histopatologis. Kasus: Dilaporkan satu kasus pemfigus vulgaris pada pasien wanita berusia 54 tahun dengan keluhan utama munculnya kulit lepuh yang mengelupas yang menyakitkan di seluruh tubuh sejak satu bulan yang lalu. Pada pemeriksaan klinis, ditemukan vesikel yang pecah dengan dasar eritematosa, erosi dengan krusta hitam di wajah; erosi multipel akibat lepuh yang pecah ditemukan generalisata; beberapa bula dengan ukuran milier-plakat ditemukan di abdomen, trunkus posterior, ekstremitas atas bilateral, dan femoralis bilateral. Hasil pemeriksaan Nikolsky sign positif serta pemeriksaan histopatologis ditemukan bula intraepidermal supabasal dengan gambaran “row of tombstone” pada dasar bula dan akantolisis. Pasien didiagnosis dengan PV dan berdasarkan Pemphigus Disease Area Index (PDAI) didapatkan skor 36 (derajat berat). Kortikosteroid dosis tinggi diberikan sebagai terapi utama pada pasien. Perbaikan klinis diamati setelah 10 hari terapi, dan resolusi lengkap dicapai setelah 14 hari. Steroid dihentikan setelah empat minggu, dan tidak ada kekambuhan yang diamati setelah empat bulan masa tindak lanjut. Diskusi: Pemfigus vulgaris ditandai akantolisis dengan gambaran khas bula suprabasal dengan “row of tombstone”. Penilaian keparahan dan respons terapi menggunakan PDAI. Kortikosteroid sistemik efektif mengendalikan penyakit. Simpulan: Histopatologi menegakkan diagnosis, dan PDAI membantu evaluasi penyakit. Penatalaksanaan dengan kortikosteroid memberikan perbaikan klinis yang baik.
Co-Authors A Nababan, Kristo Alferraly, T Ibnu Cut Putri Hazlianda Dina Arwina Dalimunthe, Dina Arwina Nababan, Kristo A Paramita, Deryne Anggia