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A Diagnostic Test of Tinea Cruris Using Polymerase Chain Reaction Restriction Fragmented Length Polymorphism Cut Putri Hazlianda; Kamaliah Muis; Isma Aprita Lubis
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Tinea cruris is the second most common dermatophytosis in the world and the most common in Indonesia. The conventional diagnostic method fungal culture is slow and less specific, therefore requiring a more rapid and exact diagnostic methods. Polymerase chain reaction (PCR) is a very sensitive and specific test to diagnose various microorganisms including pathogenic fungi. Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) is a PCR method with the addition of enzyme after amplification, therefore enabling for more specific results. Purpose: To determine the diagnostic value of PCR-RFLP in the diagnosis of tinea cruris. Methods: This study is a diagnostic test tinea cruris with PCR-RFLP by using culture as the gold standard. The specimens were skin scrapings from thirty-one patients suspected of having tinea cruris from history taking and dermatological examination. The tools and materials that were used in this study were Sabaroud’s dextrose agar media, Internal Transcribe Sequences (ITS) 1 and ITS 4 primer, and MvaI. Results: The values of the diagnostic test yielded in this study are: the sensitivity value was 75%, the specificity was 66.7%, the positive predictive value was 70.6%, the negative predictive value was 71.4%, the positive likelihood ratio was 2.25, the negative likelihood ratio was 0.38, the accuracy value was 70.9%. Conclusion: PCR-RFLP can be used as an alternative tool for the diagnosis of tinea cruris.

The Relationship Between Anxiety Level with the Onset of Acne Vulgaris in Medical Faculty of Universitas Sumatera Utara 2016 – 2018 Salsabila, Vanny; Hazlianda, Cut Putri
Sumatera Medical Journal Vol. 5 No. 2 (2022): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v5i2.7890

Acne vulgaris (AV) is a chronic inflammation of the follicle pilosebaceous induced by Propionibacterium acnes. Anxious circumstances increase the androgen hormones. This increases the production of sebum and the proliferation then activates Propionibacterium acnes, resulting in AV. To find out the relationship between levels of anxiety and the onset of AV to the Faculty of Medicine, Universitas Sumatera Utara (FK USU) 2016 – 2018 conducted observational research with cross sectional design. This research samples as many as 66 students of FK USU Group 2016 – 2018 and using stratified random sampling method. The result of anxiety level of FK USU students indicates that there are mild anxiety (92.4%) moderate anxiety (6.1%) and severe anxiety (1.5%). The AV event of FK USU students indicates that there are mild acne (51.5%) moderate acne (40.9%) severe acne (6.1%) and normal results (1.5%). With the chi square test there is a significant link between the level of anxiety and the onset of the vulgaris (p = 0.026). There is a significant relationship between the levels of anxiety with the onset of AV on student of FK USU 2016-2018.

Autoimmune Blistering Disease in Children Hazlianda, Cut Putri; Siahaan, Ade Gustina
Journal of Society Medicine Vol. 2 No. 11 (2023): November
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i11.100

The skin is a particular organ that shields the body from physical stress and other external stresses. There are three layers of skin: epidermis, dermis, and subcutis. The three layers act as interrelated units in carrying out the above functions. One of the skin diseases that can be found is an autoimmune blister or bullous disease that can affect children. Autoimmune bullous or blisters are rare in children, but their quality of life is compromised if they suffer from this disease. Included in autoimmune bullous diseases in children are Linear Immunoglobulin A Bullous Dermatosis (LABD), Dermatitis Herpetiformis (DH), Pemphigus Vulgaris (PV), Pemphigus Foliaceus (PF), Paraneoplastic Pemphigus (PNP), Bullous Pemphigoid (BP), Mucous Membrane (cicatricial) Pemphigoid (MMP), Epidermolysis Bullosa Acquisita (EBA). Diagnosing and treating patients with autoimmune bullous diseases is challenging for clinicians. The skin of infants and children is anatomically thinner than adults, so they are more prone to develop bullae when traumatized.

Current Pathogenesis and Treatment of Cutaneous Lupus Erythematosus Hazlianda, Cut Putri; Diamanda, Ika
Journal of Society Medicine Vol. 2 No. 12 (2023): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i12.107

Lupus erythematosus (LE) is a chronic autoimmune illness with a broad range of clinical symptoms. These conditions can range from systemic lupus erythematosus (SLE), which affects different organ systems in the body, to cutaneous lupus erythematosus (CLE), which affects only the skin. The precise pathophysiology of CLE is unknown, although it appears to include a complicated interaction of genetic predisposition and environmental stimuli such as UV light, medications, trauma, and hormones. The emergence of the inflammatory infiltrate seen in CLE lesions has also been documented in several studies; this information is crucial for figuring out which specific inflammatory mediators are responsible for tissue damage. Currently prescribed medications for CLE often include antimalarials, systemic corticosteroids, immunosuppressants, and immunomodulators; cytotoxic drugs are only used in the most severe instances.

Generalized Exfoliative Dermatitis Suspected Caused by COVID-19 Vaccine : A Case Report Hazlianda, Cut Putri; Dalimunthe, Dina Arwina; Astarina, Awalia
Journal of Society Medicine Vol. 2 No. 12 (2023): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i12.109

Introduction: Exfoliative dermatitis (ED) is a skin disorder characterized by the presence of erythema and scaling of the skin involving more than 90% of the total body surface area. One of the main etiologic factor of ED is drug hypersensitivity reaction. Vaccine administration can result in allergic reactions. The aim of this case report is to provide information on one of the forms of allergy to the COVID-19 vaccine, which can be ED. Case: A woman, 61 years old, with complaints of reddish patches accompanied by thickened scales and spread throughout the body accompanied by itching, pain in the skin, experiencing fatigue and chills since 3 days ago before the patient said she had received COVID-19 booster vaccine. The patient was diagnosed with generalised exfoliative dermatitis suspected to be caused by the COVID-19 vaccine. The patient was given therapy with oral methylprednisolone 36 mg/day with tapering if there was improvement, and topical urea 10% cream and hydrocortisone 2.5 % cream (face) and desoxymethasone 0.25 % cream (body). Discussion: ED is more common in men than women, with the highest incidence at the age of 40-60 years. The underlying therapy of ED is to address the aetiology and potential complications. The therapy was corticosteroids at a dose of 1-2 mg/kg/day with tapering, emollients and topical corticosteroids. The patient was given these therapies, showed clinical improvement within 5 weeks of treatment and no side effects. Conclusion: Exfoliative dermatitis can be idiopathic or secondary to drug hypersensitivity including vaccine administration. A complete history including history of drug administration and a thorough physical examination are required so that treatment can be given appropriately.

Relationship Between the Personal Hygiene and The Occurrence of Pityriasis Versicolor In Students of State Senior High School 1 Medan 2020 Nasution, Namira Afifah; Hazlianda, Cut Putri
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 1 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i1.15764

Background: Pityriasis versicolor (PV) is a superficial fungal infection on the outermost layer of skin caused by Malassezia furfur or Pityrosporum orbiculare, this infection stays for a long time, mild, and mostly the inflammation affects the face, neck, body, upper arm, axilla, thigh, and groin. PV often found in tropical areas and attack all ages, but mostly found on teenager age between 16-20 years. Self-care maintenance could be done by maintaining the good personal hygiene, because a poor personal hygiene was the risk factor that trigger pityriasis versicolor. This study has an objective to find out whether there is a relationship between personal hygiene and pityriasis versicolor of State Senior High School 1 Medan students in 2020. This study was observational with cross sectional design, the sample for this study were 100 students in State Senior High School 1 Medan in 2020 by using simple random sampling. Data was collected using an online questionnaire. Based on data from chi square method, there is a result value p=0,027 (pâ‰¤0,05). There is a meaningful relationship between personal hygiene and pityriasis versicolor. Â Pendahuluan: Pitiriasis versikolor adalah infeksi jamur superfisial pada lapisan tanduk kulit yang disebabkan oleh Malassezia furfur atau Pityrosporum orbiculare. Infeksi ini bersifat menahun, ringan, dan biasanya tanpa peradangan yang mengenai muka, leher, badan, lengan atas, ketiak, paha, dan lipatan paha. Pitiriasis versikolor banyak dijumpai di daerah tropis dan dapat menyerang semua usia, namun paling banyak pada remaja usia 16-20 tahun. Pemeliharaan perawatan diri dilakukan dengan menjaga higiene perseorangan yang baik karena higiene perseorangan yang buruk adalah faktor yang memicu pitiriasis versikolor Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara higienitas dan pityriasis versicolor pada siswa SMAN 1 tahun 2020. Metode: Penelitian ini merupakan jenis penelitian observasional dengan rancangan cross sectional. Sampel pada penelitian ini siswa-siswi SMAN 1 Medan tahun 2020 sebanyak 100 dan menggunakan metode simple random sampling. Data yang diperoleh melalui pengisian kuesioner secara online. Hasil: Berdasarkan data yang didapati menggunakan motede chi square, didapati hasil nilai p=0,027 (pâ‰¤0,05). Kesimpulan: Terdapat hubungan yang bermakna antara higiene perseorangan dengan kejadian pitiriasis versikolor.

Knowledge Level on Milk Protein Consumption Towards Acne Vulgaris for Gym Users Akmal, Mohammad Anis; Hazlianda, Cut Putri
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 1 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i1.15843

Background: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit, with a polymorphic clinical picture consisting of various skin disorders. Whey protein is also associated with potential acne triggers and is used as a supplement by young people trying to increase muscle mass. Objectives: To find out the description of the knowledge of gym users on the relationship between consuming milk protein and the incidence of acne vulgaris. Methods: This research is a descriptive study using a cross-sectional study approach. The sample was selected using a non-probability sampling technique, namely consecutive sampling with a sample size of 67 people using a questionnaire. Results: 67 gym users were selected as samples where the knowledge in the good category was as many as 3 people (4,5%), followed by the adequate category with the number of 24 people (35,8%) and the less category of 40 people (59,7%). Most sources of information obtained about the relationship between consuming milk protein to the incidence of acne vulgaris are from social media. Conclusion: The level of knowledge of gym users at the Grand Olympus Gym regarding the relationship between consuming milk protein and the incidence of acne vulgaris in general less knowledge. Latar Belakang: Akne vulgaris (AV) adalah penyakit peradangan kronis dari unit pilosebasea, dengan gambaran klinis polimorfik yang terdiri dari berbagai gangguan kulit. Whey protein dikaitkan dengan potensi pemicu jerawat dan digunakan sebagai suplemen oleh usia muda yang mencoba meningkatkan massa otot. Tujuan: Untuk mengetahui gambaran pengetahuan para pengguna gym tentang hubungan antara mengonsumsi protein susu dengan kejadian akne vulgaris. Metode: Penelitian ini merupakan studi deskriptif dengan menggunakan pendekatan studi potong lintang. Sampel dipilih menggunakan teknik non-probability sampling yaitu consecutive sampling dengan jumlah sampel sebanyak 67 orang dengan menggunakan kuesioner. Hasil: Sebanyak 67 pengguna gym dipilih sebagai sampel dimana pengetahuan dengan kategori baik sebanyak 3 orang (4,5%), diikuti kategori cukup dengan jumlah 24 orang (35,8%) dan kategori kurang sebanyak 40 orang (59,7%). Sebagian besar sumber informasi yang didapatkan tentang hubungan antara mengonsumsi protein susu dengan kejadian akne vulgaris berasal dari media sosial. Kesimpulan: Tingkat pengetahuan pengguna gym di Grand Olympus Gym mengenai hubungan antara mengonsumsi protein susu dengan kejadian jerawat (acne vulgaris) secara umum berpengetahuan kurang.

Patch Test Analysis of Channa Striata Extract Biopolymer Dalimunthe, Dina A; Lubis, Flora Marita; Hazlianda, Cut Putri; Sinaga, Riana Miranda; Dhillon, Jesryn; Hutagalung, Patricia; Berlian, Guntur
Journal of Society Medicine Vol. 4 No. 6 (2025): June
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i6.217

Introduction: Wound healing involves complex interactions between cells and mediators that occur immediately after the wound occurs and depends on nutritional factors and wound closure. Snakehead murrel fish (Channa striata) extract has been extensively researched to speed up the wound healing process because of its high amino acid content. Patch tests were carried out to assess the allergen potential of the Channa striata extract biopolymer in the form of wound dressings. Methods: Experimental study of 40 subjects who had admit patch test with various consentration of Channa striata extract biopolymer. The patch test materials divided of 5 grups. They were aquadest solution, Eucheuma cottonii biopolymer, Channa striata extract biopolymer concentrations of 5.4 g/mL, 10.8 g/mL, and 21.6 g/mL. All subjects had been assessed for skin reactions that occured after 48 hours, 72 hours, and 96 hours. Results: A total of 40 subjects met the inclusion criteria and completed informed consent. There was minimum allergen reaction (+) in slight subject in all grups except aquadest grup after 48 hours. The allergic reaction dissolve in 72 and 96 hours. An irritant reaction (IR) occurred in among all grups but indicated to the hypafix plaster. Conclusion: Patch test containing biopolymer Channa striata extract showed a minimal allergic reaction

The Relationship Between Sufficient Knowledge and Behavior of Medical Students in Faculty of Medicine Universitas Sumatera Utara regarding Acne Vulgaris Sitepu, Josapat Bima Sakti; Hazlianda, Cut Putri
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 2 (2025): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i2.14600

ABSTRACT Acne vulgaris is a chronic inflammation of pilosebaceous follicles caused by Propionibacterium acnes. The clinical symptoms are polymorphic skin eruption, especially blackheads, non-inflammatory papule, pustule, nodule, and cyst formation. Generally, patients tend to complain of the aesthetic disfigurement caused by acne vulgaris. Even though it is not life-threatening, acne vulgaris can seriously harm patientsâ€™ confidence and might cause depression. One of risk factors is lack of knowledge and bad behavior. This research aimed to study the knowledge and behavior of medical students in University of North Sumatra regarding acne vulgaris in 2018. The research was observational cross-sectional study. Eighty-eight medical students in University of North Sumatra that fulfilled the inclusion criteria in this study were recruited and were randomized using consecutive sampling. The data was obtained by filling in the questionnaire to evaluate their knowledge and behavior. The accumulated data were processed with computer. The level of knowledge of the medical students in University of North Sumatra is 43.2% (sufficient) and the behavior of the medical students in University of North Sumatra was 68.2% (sufficient). There was a significant relationship between knowledge and behavior of the medical students in University of North Sumatera and acne vulgaris. Keywords: Acne Vulgaris, Behavior, Knowledge, University Student Â ABSTRAK Acne vulgaris merupakan inflamasi kronis folikel pilosebasea yang disebabkan oleh Propionibacterium acne. Gejala klinis yang muncul umumnya berupa erupsi kulit polimorfik dengan dominasi komedo hitam, papula non-inflamasi, pustula, nodus, dan kista. Secara umum, pasien sering mengeluhkan gangguan kosmetik yang ditimbulkan akibat acne vulgaris. Walaupun tidak mengancam jiwa, acne vulgaris dapat membahayakan pasien karena dapat menyebabkan krisis kepercayaan dan depresi. Salah satu faktor risiko adalah pengetahuan dan perilaku buruk. Penelitian ini bertujuan untuk menilai pengetahuan dan sikap mahasiswa kedokteran di Universitas Sumatera Utara (USU) tentang acne vulgaris pada 2018. Penelitian ini berupa penelitian observasional potong-lintang. Sampel penelitian adalah 88 mahasiswa kedokteran USU yang memenuhi kriteria inklusi yang kemudian diacak menggunakan metode consecutive sampling. Data berasal dari kuesioner yang maharsiswa dengan acne vulgaris untuk menilai pengetahuan dan sikap yang selanjutnya diolah menggunakan komputer. Pengetahuan sampel didapati 43,2% (cukup), sedangkan sikap 68,2% (cukup). Penelitian berkesimpulan terdapat hubungan signifikan antara pengetahuan dan sikap mahasiswa kedokteran USU terkait acne vulgaris. Kata Kunci: Acne vulgaris, mahasiswa kedokteran, pengetahuan, sikap

Dermatitis Herpetiformis: An Update on Diagnosis And Treatment Hazlianda, Cut Putri; Putri, Desy Sahara
SCRIPTA SCORE Scientific Medical Journal Vol. 5 No. 2 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v5i2.15636

Introduction: Dermatitis herpetiformis is a relapsing skin disease caused by gluten sensitivity, also known as an extraintestinal manifestation of celiac disease. Methods: This article was made by reviewing 14 articles related to dermatitis herpetiformis which obtained from Pubmed, Science Direct, and Google Scholar. Discussion: Dermatitis herpetiformis is characterized by skin lesions vesicles or exoriated papules intensely itchy or excoriated papules on extensor surfaces, scalp, nuchal area, and buttocks. Dermatitis herpetiformis is primarily diagnosed through direct immunofluorescence of granular IgA deposits. However, modern and recent approaches currently use anti-TG3 antibody levels as the main serological diagnostic marker. Recent studies now confirm strict, long-term gluten free diet as the primary treatment modality. The diet is supplemented with sulfonamides as first line drugs treatment, especially dapsone. Proper diagnosis and management are important to improve the quality of life of the patients. Conclusion: Dermatitis herpetiformis is a skin disease related to hypersensitivity which requires comprehensive approach and treatment. Keyword: Celiac Disease, Dapsone, Dermatitis Herpetiformis, Direct Immunofluorescence, Gluten Free Diet Pendahuluan: Dermatitis herpetiformis, juga dikenal sebagai manifestasi ekstraintestinal penyakit celiac. Metode: Artikel ini disusun dengan meninjau 14 artikel berkaitan dengan dermatitis herpetiformis yang didapatkan pada Pubmed, Science Direct, dan Google Scholar. Pembahasan: Dermatitif herpetiformis adalah penyakit kulit yang ditandai dengan vesikel yang gatal atau papula yang terkelupas. Dermatitis herpetiformis didiagnosis terutama melalui imunofluoresensi langsung deposit IgA granular. Namun, pendekatan modern saat ini menggunakan antibodi anti-TG3 sebagai penanda diagnostik serologis utama. Studi terbaru sekarang mengkonfirmasi diet bebas gluten jangka panjang yang ketat sebagai modalitas pengobatan utama. Diet dilengkapi dengan sulfonamida sebagai pengobatan lini pertama, terutama dapson. Diagnosis dan penatalaksanaan yang tepat penting untuk meningkatkan kualitas hidup pasien. Kesimpulan: Dermatitis herpetiformis adalah penyakit kulit yang berkaitan dengan hipersensitivitas dan membutuhkan pendekatan dan tatalaksana yang komprehensif. Kata Kunci: Dapson, Dermatitis Herpetiformis, Diet Bebas Gluten, Imunofluoresensi Langsung, Penyakit Seliak

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